Systemic administration of antioxidants does not protect mice against the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP)
Abstract
We examined whether DA neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP) can be prevented by combined systemic administration of antioxidants. C57 black mice were injected s.c. with MPTP (30 mg/kg), once daily for two days, alone, or with ascorbic acid (1 g/kg), alpha-tocopherol (100 mg/kg), or dimethylsulfoxide (50 microliters) i.p. for two days before, two days with and two days after MPTP, and decapitated 30 days later. MPTP once (30 mg/kg), alone, or with ascorbic acid (200 mg/kg) or cysteamine (75 mg/kg), two days before, one day with and 4 days after, and decapitated 10 days post-MPTP. MPTP once (15 mg/kg), alone, or with ascorbic acid (500 mg/kg, alpha-tocopherol (100 mg/kg), cysteamine (50 mg/kg) or sodium selenite (2.5 mg/kg), 90 min before and again 90 min after MPTP, and decapitated 7 days later. In all experiments, the marked striatal DA depletions produced by MPTP alone (by 40-70% from controls) were unchanged by cotreatments with the various antioxidants. Findings do not favor intraneuronal generation of superoxides and related cytotoxic free radicals as a major factor in the DA neurotoxicity of MPTP. They suggest that if natural Parkinson's disease is caused by an MPTP-like neurotoxin, early treatment with antioxidants is unlikely to protect nigrostriatal neurons and prevent disease progression.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Systematic administration of vitamin E did not show protective effect in laboratory animals including inability to attenuate dopamine depletion.
“Systematic administration of vitamin E did not show a protective effect in laboratory animals including the inability to attenuate dopamine depletion (Martinovits et al. 1986; Gong et al. 1991).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Martinovits et al. 1986
Cites
Burns, R. S., Chiueh, C. C., Markey, S. P., Ebert, M. H., Jacobowitz, D. M., & Kopin, I. J. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.14.4546 · Cited by 2,149 · see citing works
Metabolism of the neurotoxic tertiary amine, MPTP, by brain monoamine oxidase
Chiba, K., Trevor, A. J., & Castagnoli, N. (1984) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(84)91293-2 · Cited by 1,098 · see citing works
Heikkila, R. E., Manzino, L., Cabbat, F. S., & Duvoisin, R. C. (1984) · Nature · doi:10.1038/311467a0 · Cited by 1,010 · see citing works
Intraneuronal generation of a pyridinium metabolite may cause drug-induced parkinsonism
Markey, S. P., Johannessen, J. N., Chiueh, C. C., Burns, R. S., & Herkenham, M. A. (1984) · Nature · doi:10.1038/311464a0 · Cited by 786 · see citing works
Glucocorticoids Potentiate Ischemic Injury to Neurons: Therapeutic Implications
Sapolsky, R. M., & Pulsinelli, W. A. (1985) · Science · doi:10.1126/science.4035356 · Cited by 678 · see citing works
Pargyline Prevents MPTP-Induced Parkinsonism in Primates
Langston, J. W., Irwin, I., Langston, E. B., & Forno, L. S. (1984) · Science · doi:10.1126/science.6332378 · Cited by 581 · see citing works
AETIOLOGY OF PARKINSON'S DISEASE
Calne, D., & Langston, J. W. (1983) · The Lancet · doi:10.1016/s0140-6736(83)90802-4 · Cited by 469 · see citing works
Langston, J. W., Irwin, I., Langston, E. B., & Forno, L. S. (1984) · Neuroscience Letters · doi:10.1016/0304-3940(84)90293-3 · Cited by 435 · see citing works
Uptake of MPP(+) by dopamine neurons explains selectivity of parkinsonism-inducing neurotoxin, MPTP
Javitch, J. A., & Snyder, S. H. (1984) · European Journal of Pharmacology · doi:10.1016/0014-2999(84)90740-4 · Cited by 317 · see citing works
Hallman, H., Lange, L., Olson, L., Strömberg, I., & JONSSON, G. (1985) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1985.tb07120.x · Cited by 281 · see citing works
A mechanism of paraquat toxicity in mice and rats
Bus, J. S., Cagen, S. Z., Olgaard, M. K., et al. (1976) · Toxicology and Applied Pharmacology · doi:10.1016/0041-008x(76)90073-9 · Cited by 253 · see citing works
Oxy-radical toxicity in catecholamine neurons.
Cohen, G. (1984) · PubMed · Cited by 224 · see citing works
Manganese neurotoxicity: a model for free radical mediated neurodegeneration?
Donaldson, J. C., McGregor, D., & LaBella, F. S. (1982) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y82-208 · Cited by 163 · see citing works
Collins, M. A., & Neafsey, E. J. (1985) · Neuroscience Letters · doi:10.1016/0304-3940(85)90016-3 · Cited by 112 · see citing works
Deprenyl Protects Dopamine Neurons from the Neurotoxic Effect of 1‐Methyl‐4‐Phenylpyridinium Ion
Mytilineou, C., & Cohen, G. (1985) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1985.tb10556.x · Cited by 107 · see citing works
Poirier, J., Donaldson, J., & Barbeau, A. (1985) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(85)91639-0 · Cited by 95 · see citing works
Melamed, E., Rosenthal, J., Cohen, O. S., et al. (1985) · European Journal of Pharmacology · doi:10.1016/0014-2999(85)90201-8 · Cited by 68 · see citing works
Self-citationSahgal, A., Andrews, J. S., Biggins, J. A., et al. (1984) · Neuroscience Letters · doi:10.1016/0304-3940(84)90016-8 · Cited by 59 · see citing works
Mesolimbic dopaminergic neurons are not spared by MPTP neurotoxicity in mice
Melamed, E., Rosenthal, J., Globus, M., Cohen, O. S., Frucht, Y., & Uzzan, A. (1985) · European Journal of Pharmacology · doi:10.1016/0014-2999(85)90528-x · Cited by 41 · see citing works
Self-citationPoirier, J., & Barbeau, A. (1985) · Neuroscience Letters · doi:10.1016/0304-3940(85)90276-9 · Cited by 41 · see citing works
Clinical Trial for Parkinson's Disease?
Lewin, R. A. (1985) · Science · doi:10.1126/science.3931220 · Cited by 31 · see citing works
Amphetamine, but not reserpine, protects mice against dopaminergic neurotoxicity of MPTP
Melamed, E., Rosenthal, J., COHEN, O., Uzzan, A., & Globus, M. (1985) · Neuropharmacology · doi:10.1016/0028-3908(85)90047-4 · Cited by 22 · see citing works
Self-citationSchmidt, C. J., Bruckwick, E. A., & Lovenberg, W. M. (1985) · European Journal of Pharmacology · doi:10.1016/0014-2999(85)90361-9 · Cited by 21 · see citing works
MPTP-Induced Parkinsonian Syndromes in Humans and Animals
Kopin, I. J., Burns, S., Chiueh, C. C., et al. (1986) · Advances in behavioral biology · doi:10.1007/978-1-4613-2179-8_59 · Cited by 14 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Reactive Oxygen Species and the Central Nervous System
Halliwell, B. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb10990.x · Cited by 2,947 · see citing works
Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging
Jomova, K., Raptova, R., Alomar, S. Y., Alwasel, S. H., Nepovimova, E., Kuca, K., & Valko, M. (2023) · Archives of Toxicology · doi:10.1007/s00204-023-03562-9 · Cited by 2,638 · see citing works
Taghizadeh, M., Tamtaji, O. R., Dadgostar, E., Daneshvar Kakhaki, R., Bahmani, F., Abolhassani, J., Aarabi, M. H., Kouchaki, E., Memarzadeh, M. R., & Asemi, Z. (2017) · Neurochemistry International · doi:10.1016/j.neuint.2017.03.014 · Cited by 162 · see citing works
- Authors
- Martinovits, G., Melamed, E., Cohen, O., Rosenthal, J., & Uzzan, A.
- Affiliations
- Hadassah Medical Center (IL)
- Corresponding author
- Melamed, Eldad
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 1986-08
- Volume
- 69
- Issue
- 2
- Pages
- 192-197
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W2036637507
- Cited by
- 67
- References
- 24
- Citations by year
- 2023: 1 · 2022: 1 · 2021: 1 · 2020: 2 · 2017: 2 · 2016: 1 · 2015: 1
- FWCI
- 4.72
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
- Keywords
- MPTP, dopaminergic neurotoxicity, antioxidants, Parkinson's disease, vitamin C, alpha-tocopherol, cysteamine, sodium selenite, dimethyl sulfoxide, striatal dopamine depletion, nigrostriatal neurons, superoxide, free radicals, neuroprotection
- MeSH terms
- Animals, Antioxidants, Ascorbic Acid, Brain Chemistry, Corpus Striatum, Dimethyl Sulfoxide, Dopamine, Drug Administration Schedule, Drug Combinations, Injections, Subcutaneous, Male, Mice, Inbred C57BL, Neurotoxins, Pyridines, Substantia Nigra, Vitamin E, 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
