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Muscarinic receptor activation facilitates the induction of long-term potentiation (LTP) in the rat dentate gyrus
Abstract
Bath application of two different concentrations of muscarine produced two different effects on evoked responses in the dentate gyrus of rat hippocampal slices. A concentration of 1 microM muscarine did not affect the evoked population spike or excitatory postsynaptic potential (EPSP), but facilitated the induction of LTP. In contrast, a concentration of 10 microM muscarine depressed both the population spike and EPSP, but had no effect on LTP induction. The M1 muscarinic receptor antagonist pirenzepine (1 microM) blocked the muscarine-induced facilitation of LTP, but had no effect on the depression of evoked responses. These data suggest that activation of M1 receptors can facilitate the induction of LTP.
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“The enhancement of long-term encoding could be at least partially mediated by the cholinergic enhancement of long-term potentiation in the hippocampus (Blitzer et al., 1990; Burgard and Sarvey, 1990; Auerbach and Segal, 1994; Isaac et al., 2009).”
From Modes and models of forebrain cholinergic neuromodulation of cognition (2011) · cites this paper as Burgard and Sarvey, 1990
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Metadata
- Authors
- Burgard, E. C., & Sarvey, J. M.
- Affiliations
- Uniformed Services University of the Health Sciences (US)
- Corresponding author
- Sarvey, John M.
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 1990-08
- Volume
- 116
- Issue
- 1-2
- Pages
- 34-39
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W2072926455
- Cited by
- 188
- References
- 24
- Citations by year
- 2026: 2 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 3 · 2019: 4 · 2018: 3 · 2017: 2 · 2016: 1 · 2015: 1 · 2014: 5 · 2013: 1 · 2012: 10
- FWCI
- 2.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ns023865-07)
- National Institute of Neurological Disorders and Stroke (NS-23865)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Keywords
- muscarinic receptors, M1 muscarinic receptor, long-term potentiation, LTP induction, dentate gyrus, hippocampus, muscarine, pirenzepine, excitatory postsynaptic potentials, synaptic plasticity
- MeSH terms
- Animals, Electric Stimulation, Evoked Potentials, Hippocampus, Kinetics, Muscarine, Pirenzepine, Receptors, Muscarinic, Rats, In Vitro Techniques
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