Decrease in exploratory behavior in naturally occurring cholecystokinin (CCK)-A receptor gene knockout rats
Abstract
We recently found a specific strain of rats (Otsuka Long Evans Tokushima Fatty; OLETF rats) lacking cholecystokinin (CCK)-A receptor because of a genetic abnormality. Since CCK is an abundant neurotransmitter peptide in the brain, we examined whether these animals exhibit any behavioral abnormalities by conducting open-field tests. OLETF rats showed hypolocomotor activity and a decrease in the incidence of rearing in open-field tests. CCK release from the synaptosomes, and levels of CCK and CCK-B receptor mRNAs were the same as those observed in normal rats. It is suggested that the decreased exploration in OLETF rats may be due to the lack of CCK-A receptor.
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Knockout mouse models of these genes exhibit characteristic neurological functional deficits (Rab3a, Penk or Cck).
“Knockout mouse models of these genes exhibit characteristic neurological functional deficits (Rab3a63, Penk64 or Cck65).”
From Cell type-specific transcriptional programs in mouse prefrontal cortex during adolescence and addiction (2019) · cites this paper as [65]
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- Authors
- Kobayashi, S., Ohta, M., Miyasaka, K., & Funakoshi, A.
- Affiliations
- Tokyo Metropolitan Institute of Gerontology (JP)
- National Hospital Organization Kyushu Cancer Center (JP)
- Corresponding author
- Miyasaka, Kyoko
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 1996-08
- Volume
- 214
- Issue
- 1
- Pages
- 61-64
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W2047497651
- Cited by
- 44
- References
- 22
- Citations by year
- 2023: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2014: 1 · 2013: 1
- FWCI
- 0.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- CCK-A receptor, OLETF rats, exploratory behavior, rearing behavior, CCK-B receptor, synaptosomes
- MeSH terms
- Animals, Behavior, Animal, Exploratory Behavior, Grooming, Hormone Antagonists, Male, Motor Activity, Mutation, Proglumide, Rats, Inbred Strains, Rats, Mutant Strains, Receptors, Cholecystokinin, Reference Values, Receptor, Cholecystokinin A, Rats
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