The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Lack of analgesic effect of opioids on neuropathic and idiopathic forms of pain
Abstract
The aim of the present study has been to assess the responsiveness of various types of chronic pain to opioids given i.v. and tested against placebo in a double-blind, randomized fashion. Pain classified as primary nociceptive was effectively alleviated (P greater than 0.001) while neuropathic deafferentation pain was not significantly influenced by morphine or equivalent doses of other opioids. Also 'idiopathic' pain, defined as chronic pain with no or little demonstrable pathology, failed to respond. The results were not related to whether the patients were regular users of narcotic analgesics or not. The outcome of our double-blind opioid test has proved useful to justify a continued, or discontinued, use of narcotic medication in individual patients. It may also support the indication and choice of invasive stimulation procedures (spinal cord or brain). The results of the study illustrate the misconception of chronic pain as an entity and highlight the importance of recognizing different neurobiological mechanisms and differences in responsiveness to analgesic drugs as well as to non-pharmacological modes of treatment. The opioid test has thus become a valuable tool in pain analysis and helpful as a guide for further treatment.
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Cites
Chronic use of opioid analgesics in non-malignant pain: Report of 38 cases
Portenoy, R. K., & Foley, K. M. (1986) · Pain · doi:10.1016/0304-3959(86)90091-6 · Cited by 897
Pain due to peripheral nerve damage: An hypothesis
Asbury, A. K., & Fields, H. L. (1984) · Neurology · doi:10.1212/wnl.34.12.1587 · Cited by 239
Evidence for opioid and non-opioid forms of stimulation-produced analgesia in the rat
Cannon, J. T., Prieto, G. J., Lee, A., & Liebeskind, J. C. (1982) · Brain Research · doi:10.1016/0006-8993(82)90255-4 · Cited by 210
Drug Abuse and Dependency in Patients With Chronic Pain
Maruta, T., Swanson, D. W., & Finlayson, R. E. (1979) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(25)19043-5 · Cited by 161
Electrical stimulation of the brain in treatment of chronic pain
Young, R. F., Kroening, R. J., Fulton, W., Feldman, R. A., & Chambi, I. (1985) · Journal of neurosurgery · doi:10.3171/jns.1985.62.3.0389 · Cited by 155
Drug utilization patterns in chronic pain patients
Turner, J. A., Calsyn, D. A., Fordyce, W. E., & Ready, B. L. (1982) · Pain · doi:10.1016/0304-3959(82)90180-4 · Cited by 124
Pain modulation by 5-hydroxytryptaminergic agents and morphine as measured by three pain tests
Dennis, S. G., & Melzack, R. (1980) · Experimental Neurology · doi:10.1016/0014-4886(80)90210-1 · Cited by 114
Tamsen, A., Sakurada, T., Wahlström, A., Terenius, L. Y., & Hartvig, P. (1982) · Pain · doi:10.1016/0304-3959(82)90027-6 · Cited by 87
A simultaneous comparison of Fentanylʼs analgesic effects on experimental and clinical pain
Price, D. D., Harkins, S. W., Rafii, A., & Price, C. (1986) · Pain · doi:10.1016/0304-3959(86)90042-4 · Cited by 83
Are the endorphins active in clinical pain states? Narcotic antagonism in chronic pain patients
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Cited by
Millan, M. J. (2002) · Progress in Neurobiology · doi:10.1016/s0301-0082(02)00009-6 · Cited by 3,035
Opioids in chronic non-cancer pain: systematic review of efficacy and safety
Kalso, E., Edwards, J. E., Moore, A. R., & McQuay, H. J. (2004) · Pain · doi:10.1016/j.pain.2004.09.019 · Cited by 1,216
Complex Regional Pain Syndromes: Guidelines for Therapy
Stanton-Hicks, M., Baron, R., Boas, R., Gordh, T., Harden, N., Hendler, N., Koltzenburg, M., Raj, P., & Wilder, R. (1998) · The Clinical Journal of Pain · doi:10.1097/00002508-199806000-00012 · Cited by 378
Clinical characteristics and economic costs of patients with painful neuropathic disorders
Berger, A., Dukes, E. M., & Oster, G. (2004) · The Journal of Pain · doi:10.1016/j.jpain.2003.12.004 · Cited by 351
Metadata
- Authors
- Arnér, S., & Meyerson, B. A.
- Venue
- Pain
- Published
- 1988-04
- Volume
- 33
- Issue
- 1
- Pages
- 11-23
- ISSN
- 0304-3959 (ISSN-L)
- OpenAlex
- W2004035928
- Cited by
- 991
- References
- 13
- FWCI
- 43.85
- Type
- journal article
- Language
- en
- Open access
- closed
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- Arnér, S., & Meyerson, B. A. (1988). Lack of analgesic effect of opioids on neuropathic and idiopathic forms of pain. Pain. https://doi.org/10.1016/0304-3959(88)90198-4
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
