Developing a database of published reports of randomised clinical trials in pain research 1
Abstract
A database of randomised clinical trials (RCTs) in pain research published from 1950 to 1990 was created following an extensive literature search. By applying a refined MEDLINE search strategy from 1966 to 1990 and by hand-searching more than 1,000,000 pages of a total of 40 biomedical journals published during the period 1950-1990, more than 8000 RCTs were identified. The RCTs were published in more than 800 journals and over 85% appeared between 1976 and 1990. If the trend of the last 15 years persists, a total of more than 15 000 RCTs will be published in pain relief by the year 2000. A detailed description of methods to ensure efficient use of resources during the identification, retrieval and management of the information in pain relief and other fields is given. Emphasis is made on the importance of refining MEDLINE search strategies, on the use of volunteers to hand-search journals and on careful monitoring of each of the steps of the process. The potential uses of the database to guide clinical and research decisions are discussed.
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Study quality was judged by proper conduct of randomization, concealment of treatment allocation, similarity of treatment groups at baseline, provision of eligibility criteria, completeness of follow-up, and use of intention-to-treat analysis, and quantified using the Jadad score.
“Study quality was judged by the proper conduct of randomization, concealment of treatment allocation, similarity of treatment groups at baseline, the provision of a description of the eligibility criteria, completeness of follow-up, and use of intention-to-treat analysis, and was quantified using the Jadad score (26).”
From Effects of Fibrates in Kidney Disease (2012) · cites this paper as [26]
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Drug-Induced Reduction in Albuminuria Is Associated with Subsequent Renoprotection: A Meta-Analysis
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Single dose oral ibuprofen plus paracetamol (acetaminophen) for acute postoperative pain
Derry, C. J., Derry, S., & Moore, R. A. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd010210.pub2 · Cited by 173 · see citing works
Gaskell, H., Derry, S., Moore, R. A., & McQuay, H. J. (2009) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002763.pub2 · Cited by 141 · see citing works
Self-citationThe effects of Tai Chi on bone mineral density in postmenopausal women: a systematic review
Wayne, P. M., Kiel, D. P., Krebs, D. E., Davis, R. B., Savetsky-German, J., Connelly, M., & Buring, J. E. (2007) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2007.02.012 · Cited by 113 · see citing works
- Authors
- Jadad, A. R., Carroll, D., Moore, A., & McQuay, H.
- Affiliations
- University of Oxford (GB)
- Venue
- Pain
- Published
- 1996-08
- Volume
- 66
- Issue
- 2
- Pages
- 239-246
- ISSN
- 0304-3959 (ISSN-L)
- OpenAlex
- W2092890771
- Cited by
- 271
- References
- 0
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 1 · 2021: 2 · 2020: 2 · 2019: 4 · 2018: 2 · 2017: 5 · 2016: 10 · 2015: 16 · 2014: 10 · 2013: 21 · 2012: 20
- FWCI
- 18.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pain (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Decision Sciences › Statistics, Probability and Uncertainty › Meta-analysis and systematic reviews
- Social Sciences › Decision Sciences › Statistics, Probability and Uncertainty › scientometrics and bibliometrics research
- Health Sciences › Health Professions › General Health Professions › Health Sciences Research and Education
- Keywords
- randomized controlled trials, pain research, analgesia, MEDLINE search strategy, bibliographic databases, information retrieval, history of pain research, biomedical journals
- MeSH terms
- Information Systems, Medical Informatics Computing, Pain, Randomized Controlled Trials as Topic, Databases, Bibliographic, MEDLINE, Pain Management
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