Insulin-like growth-factor binding protein (IGFBP) serum levels and hepatic IGFBP-2 and -3 mRNA expression in diabetic and insulin-treated swine (Sus scrofa).

White, Michael E.; Leaman, Douglas W.; Ramsay, Timothy G.; Kampman, Kimberly A.; Ernst, Catherine W.; Osborne, Jeanne M.

doi:10.1016/0305-0491(93)90311-r

Cited by 8Growth Hormone and Insulin-like Growth FactorsPancreatic function and diabetesFibroblast Growth Factor Research

Insulin-like growth-factor binding protein (IGFBP) serum levels and hepatic IGFBP-2 and -3 mRNA expression in diabetic and insulin-treated swine (Sus scrofa).

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White, Michael E., Leaman, Douglas W., Ramsay, Timothy G., Kampman, Kimberly A., Ernst, Catherine W., Osborne, Jeanne M.·1993·Comparative Biochemistry and Physiology Part B Comparative Biochemistry

DOI 10.1016/0305-0491(93)90311-r

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Abstract

1. Diabetes had no significant effect on IGFBP-3 message and serum levels however, subsequent insulin treatment caused more than a two-fold increase in both hepatic IGFBP-3 mRNA and serum levels above controls (P < 0.05). 2. The induction of diabetes in pigs significantly increased the steady state levels of IGFBP-2 mRNA in the liver of young swine (P < 0.05). 3. Both liver message and serum IGFBP-2 were reduced to control levels with insulin therapy. 4. We report here that in addition to its affects on IGFBP-2, insulin is involved in the regulation of IGFBP-3 expression.

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Hepatic Igfbp-2 expression is tonically inhibited by insulin and dramatically up-regulated by insulin deficiency.
“hepatic Igfbp-2 expression is tonically inhibited by insulin and hence dramatically up-regulated by insulin deficiency (50 -52).”
From Leptin Activates a Novel CNS Mechanism for Insulin-Independent Normalization of Severe Diabetic Hyperglycemia (2011) · cites this paper as [52]

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Leptin and the Central Nervous System Control of Glucose Metabolism
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Background
Leptin Activates a Novel CNS Mechanism for Insulin-Independent Normalization of Severe Diabetic Hyperglycemia
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Authors: White, M. E., Leaman, D. W., Ramsay, T. G., Kampman, K. A., Ernst, C. W., & Osborne, J. M.
Affiliations: University of Minnesota (US)
The Ohio State University (US)
Corresponding author: White, Michael E.
ORCID: White, Michael E.
Ramsay, Timothy G.
Ernst, Catherine W.
Venue: Comparative Biochemistry and Physiology Part B Comparative Biochemistry
Publisher: Elsevier BV
Published: 1993-10
Volume: 106
Issue: 2
Pages: 341-347
ISSN: 0305-0491 (ISSN-L)
DOI: 10.1016/0305-0491(93)90311-r
OpenAlex: W2026962931
Cited by: 8
References: 28
Citations by year: 2013: 1
FWCI: 0.30
Type: journal article
Language: en
Open access: green
works.bepress.com
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Comparative Biochemistry and Physiology Part B Comparative Biochemistry (publishedVersion)
PubMed (publishedVersion)
CORE Scholar (Wright State University) (submittedVersion)
Journal of Bioresource Management (submittedVersion, cc-by)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fibroblast Growth Factor Research
Keywords: IGF binding proteins, IGFBP-2, IGFBP-3, insulin therapy, diabetes mellitus, hepatic mRNA expression, pigs
MeSH terms: Animals, Carrier Proteins, Diabetes Mellitus, Experimental, Growth Inhibitors, Insulin, Liver, Male, RNA, Messenger, Swine, Insulin-Like Growth Factor Binding Proteins, Insulin-Like Growth Factor Binding Protein 2

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Insulin-like growth-factor binding protein (IGFBP) serum levels and hepatic IGFBP-2 and -3 mRNA expression in diabetic and insulin-treated swine (Sus scrofa).

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