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Cited by 88Neuroendocrine regulation and behaviorNeuroscience and Neuropharmacology ResearchNeuropeptides and Animal Physiology

Axon collaterals of supraoptic neurones: anatomical and electrophysiological evidence for their existence in the lateral hypothalamus

Mason, W.T., Ho, Y.W., Hatton, G.I.·1984·Neuroscience
DOI 10.1016/0306-4522(84)90221-5
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Abstract

The magnocellular neurones of the supraoptic nucleus which synthesize and secrete vasopressin and oxytocin have been commonly regarded as simple "output" neurones in that they receive an input, generate an action potential and in turn release hormone from their terminals in the posterior pituitary. Three lines of evidence are presented which suggest that rat supraoptic nucleus neurons also have axon collaterals which terminate in the hypothalamus close to the nucleus. Small injections of horseradish peroxidase were made directly into the nucleus in hypothalamic slices, allowing visualization of the axons of supraoptic neurones. Collaterals of these axons could be observed in regions both dorsal and dorsolateral to the supraoptic nucleus. In a separate series of experiments, sections of perfusion-fixed hypothalamus were stained for vasopressin and oxytocin using specific antisera. Peptide-containing collaterals of both types were observed near the supraoptic nucleus, in a region similar to that seen after horseradish peroxidase injections. Finally, electrophysiological studies were carried out on hypothalamic slices containing the supraoptic nucleus. A small concentric bipolar stimulating electrode was placed directly into the nucleus and activity of lateral hypothalamic neurones within 0.1-1 mm of the nucleus was recorded. Of 68 neurones studied, 52 were excited by supraoptic stimulation via a synaptic pathway that could be blocked by Ca2+ -free solutions containing 18 mM Mg2+. These studies suggest that supraoptic neurones communicate via axon collaterals with other neurones in the lateral hypothalamus, in addition to their previously well characterised functional role in neurosecretion.

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  • Innocuous somatosensory stimulation such as touch, warm temperature, vibration, and electroacupuncture increase oxytocin levels in plasma and cerebrospinal fluid.

    “Innocuous somatosensory stimulation such as touch, warm temperature, vibration, and electroacupuncture increase oxytocin levels in plasma and cerebrospinal fluid [91, 92].”

    From Oxytocin and the Neural Mechanisms Regulating Social Cognition and Affiliative Behavior (2009) · cites this paper as [91]

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Authors
Mason, W. T., Ho, Y. W., & Hatton, G. I.
Venue
Neuroscience
Publisher
Elsevier BV
Published
1984-01
Volume
11
Issue
1
Pages
169-182
ISSN
0306-4522 (ISSN-L)
DOI
10.1016/0306-4522(84)90221-5
OpenAlex
W2050299793
Cited by
87
References
31
Citations by year
2026: 1 · 2021: 1 · 2020: 1 · 2017: 3 · 2016: 1 · 2015: 1 · 2014: 3 · 2013: 1
FWCI
13.62
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords
supraoptic nucleus, axon collaterals, lateral hypothalamus, vasopressin, oxytocin, magnocellular neurons, hypothalamic neurons, synaptic transmission, neurosecretion
MeSH terms
Animals, Axons, Brain Mapping, Electrophysiology, Horseradish Peroxidase, Hypothalamic Area, Lateral, Neural Pathways, Synaptic Transmission, Oxytocin, Supraoptic Nucleus, Vasopressins, Rats, In Vitro Techniques

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