Further substantiation of a significant role for the sympathetic nervous system in inflammation.
Abstract
This study provides significant new evidence substantiating a role of the postganglionic sympathetic neuron in plasma extravasation in the knee-joint of the rat. Increased plasma extravasation produced by the potent inflammatory mediator bradykinin was mimicked by 6-hydroxydopamine, a selective stimulator of sympathetic fibers. Various treatments (chemical sympathectomy, co-perfusion with the local anesthetic lidocaine, or co-perfusion with depolarizing concentrations of potassium) similarly modulated plasma extravasation induced by both bradykinin and 6-hydroxydopamine, but not that produced by platelet activating factor. We also showed that bradykinin is able to release norepinephrine in the knee-joint, indicating action on the sympathetic postganglionic neuron. In summary, these experiments provide substantial additional evidence supporting a significant contribution of the sympathetic post-ganglionic neuron terminal to inflammatory plasma extravasation.
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Activity in sympathetic fibers can also contribute to Evans Blue dye extravasation.
“and that activity in sympathetic fibers can also contribute [14].”
From Sprouted Innervation into Uterine Transplants Contributes to the Development of Hyperalgesia in a Rat Model of Endometriosis (2012) · cites this paper as [14]
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“This method relies on the fact that activity of Cfibers produces the neurogenic contribution to EB extravasation [13] and that activity in sympathetic fibers can also contribute [14].”
- Authors
- Green, P. G., Luo, J., Heller, P. H., & Levine, J. D.
- Affiliations
- University of California, San Francisco (US)
- Corresponding author
- Levine, J.D.
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 1993-08
- Volume
- 55
- Issue
- 4
- Pages
- 1037-1043
- ISSN
- 0306-4522 (ISSN-L)
- OpenAlex
- W2081270327
- Cited by
- 76
- References
- 50
- Citations by year
- 2024: 1 · 2021: 1 · 2019: 1 · 2018: 1 · 2016: 1 · 2015: 2 · 2014: 2 · 2013: 2 · 2012: 4
- FWCI
- 2.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Arcadia Fund
- National Institutes of Health (5r01am032634-03)
- Topics
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Genetics › Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
- Keywords
- sympathetic nervous system, postganglionic sympathetic neurons, plasma extravasation, inflammation, bradykinin, 6-hydroxydopamine, chemical sympathectomy, lidocaine, potassium depolarization, noradrenaline release, platelet-activating factor, knee joint, inflammatory mediators
- MeSH terms
- Animals, Arthritis, Bradykinin, Exudates and Transudates, Inflammation, Knee Joint, Lidocaine, Male, Norepinephrine, Platelet Activating Factor, Potassium, Sympathectomy, Chemical, Sympathetic Nervous System, Oxidopamine, Rats, Sprague-Dawley, Sympathetic Fibers, Postganglionic, Rats
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