Cited by 76Pain Mechanisms and TreatmentsCoagulation, Bradykinin, Polyphosphates, and AngioedemaVagus Nerve Stimulation Research

Further substantiation of a significant role for the sympathetic nervous system in inflammation.

Green, P.G., Luo, J., Heller, P.H., Levine, J.D.·1993·Neuroscience

Abstract

This study provides significant new evidence substantiating a role of the postganglionic sympathetic neuron in plasma extravasation in the knee-joint of the rat. Increased plasma extravasation produced by the potent inflammatory mediator bradykinin was mimicked by 6-hydroxydopamine, a selective stimulator of sympathetic fibers. Various treatments (chemical sympathectomy, co-perfusion with the local anesthetic lidocaine, or co-perfusion with depolarizing concentrations of potassium) similarly modulated plasma extravasation induced by both bradykinin and 6-hydroxydopamine, but not that produced by platelet activating factor. We also showed that bradykinin is able to release norepinephrine in the knee-joint, indicating action on the sympathetic postganglionic neuron. In summary, these experiments provide substantial additional evidence supporting a significant contribution of the sympathetic post-ganglionic neuron terminal to inflammatory plasma extravasation.

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Crossref · 10.1016/0306-4522(93)90317-9

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Authors
Green, P. G., Luo, J., Heller, P. H., & Levine, J. D.
Affiliations
University of California, San Francisco (US)
Corresponding author
Levine, J.D.
Venue
Neuroscience
Publisher
Elsevier BV
Published
1993-08
Volume
55
Issue
4
Pages
1037-1043
ISSN
0306-4522 (ISSN-L)
OpenAlex
W2081270327
Cited by
76
References
50
Citations by year
2024: 1 · 2021: 1 · 2019: 1 · 2018: 1 · 2016: 1 · 2015: 2 · 2014: 2 · 2013: 2 · 2012: 4
FWCI
2.44
Type
journal article
Language
en
Open access
closed
Locations
  • Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Arcadia Fund
  • National Institutes of Health (5r01am032634-03)
Topics
  • Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
  • Health Sciences › Medicine › Genetics › Coagulation, Bradykinin, Polyphosphates, and Angioedema
  • Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
Keywords
sympathetic nervous system, postganglionic sympathetic neurons, plasma extravasation, inflammation, bradykinin, 6-hydroxydopamine, chemical sympathectomy, lidocaine, potassium depolarization, noradrenaline release, platelet-activating factor, knee joint, inflammatory mediators
MeSH terms
Animals, Arthritis, Bradykinin, Exudates and Transudates, Inflammation, Knee Joint, Lidocaine, Male, Norepinephrine, Platelet Activating Factor, Potassium, Sympathectomy, Chemical, Sympathetic Nervous System, Oxidopamine, Rats, Sprague-Dawley, Sympathetic Fibers, Postganglionic, Rats

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