The DOI matches its Crossref record; 46 of the 48 references it cites were found in a registry or an index.
Vincristine hyperalgesia in the rat: A model of painful vincristine neuropathy in humans
Abstract
To investigate the mechanism of vincristine-induced pain in humans undergoing chemotherapy we have established a model of vincristine-induced hyperalgesia in rat. Vincristine (100 micrograms/kg) was administered daily over a period of two weeks. An acute dose-dependent decrease in mechanical nociceptive threshold and an increased response to non-noxious mechanical stimuli ("hyperalgesia") occurred after the second day of administration. Chronic lowered threshold and increased response to stimuli (determined 24 h after each injection) was first noted during the second week of vincristine administration. Responses gradually returned to baseline during the two weeks following discontinuation of treatment. Vincristine also increased sensitivity to heat stimulation. At a dose that produced hyperalgesia (100 micrograms/kg), vincristine did not cause a significant motor deficit. Peripheral administration of a mu-opioid agonist did not reduce vincristine-induced acute hyperalgesia. Hyperalgesia induced by vincristine in the rat provides a good model for the experimental study of painful peripheral neuropathies in human patients receiving vincristine as a chemotherapeutic agent.
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“In rats, 10 daily injections of vincristine (0.02, 0.1, or 0.2 mg/kg, intravenous) with a 2-day drug-free interval after the fifth day, induced hyperalgesia (Aley et al, 1996), and allodynia (Authier et al, 1999).”
From The endogenous cannabinoid system: a budding source of targets for treating inflammatory and neuropathic pain (2018) · cites this paper as Aley et al, 1996
Citations
Cites
A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia
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Nerve growth factor-induced hyperalgesia in the neonatal and adult rat
Lewin, G. R., Ritter, A., & Mendell, L. M. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-05-02136.1993 · Cited by 562
Myelinated afferents signal the hyperalgesia associated with nerve injury
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Cutaneous sensory receptors in the rat foot
Leem, J. W., Willis, W. D., & Chung, J. M. (1993) · Journal of Neurophysiology · doi:10.1152/jn.1993.69.5.1684 · Cited by 410
Neurotoxicity of Commonly Used Antineoplastic Agents
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Research works printed but not linked: 2
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Gatchel, R. J., Peng, Y. B., Peters, M. L., Fuchs, P. N., & Turk, D. C. (2007) · Psychological Bulletin · doi:10.1037/0033-2909.133.4.581 · Cited by 3,392
Models and Mechanisms of Hyperalgesia and Allodynia
Sandkühler, J. (2009) · Physiological Reviews · doi:10.1152/physrev.00025.2008 · Cited by 1,148
Ethosuximide reverses paclitaxel- and vincristine-induced painful peripheral neuropathy
Flatters, S. J. L., & Bennett, G. J. (2004) · Pain · doi:10.1016/j.pain.2004.01.029 · Cited by 576
Are the symptoms of cancer and cancer treatment due to a shared biologic mechanism?
Cleeland, C. S., Bennett, G. J., Dantzer, R., Dougherty, P. M., Dunn, A. J., Meyers, C. A., Miller, A. H., Payne, R., Reuben, J. M., Wang, X. S., et al. (2003) · Cancer · doi:10.1002/cncr.11382 · Cited by 528
Signaling Pathways in Sensitization: Toward a Nociceptor Cell Biology
Hucho, T. B., & Levine, J. D. (2007) · Neuron · doi:10.1016/j.neuron.2007.07.008 · Cited by 491
Self-citation
Metadata
- Authors
- Aley, K. O., Reichling, D. B., & Levine, J. D.
- Affiliations
- University of California, San Francisco (US)
- Corresponding author
- Levine, J.D.
- ORCID
- Levine, J.D.
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 1996-07
- Volume
- 73
- Issue
- 1
- Pages
- 259-265
- ISSN
- 0306-4522 (ISSN-L)
- OpenAlex
- W2004637463
- Cited by
- 185
- References
- 48
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 5 · 2023: 3 · 2022: 3 · 2021: 3 · 2020: 5 · 2019: 3 · 2018: 4 · 2017: 9 · 2016: 1 · 2015: 4 · 2014: 9 · 2013: 10 · 2012: 9
- FWCI
- 1.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Cancer Treatment and Pharmacology
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Keywords
- vincristine, chemotherapy-induced peripheral neuropathy, hyperalgesia, peripheral neuropathic pain, mechanical nociception, thermal sensitivity, mu-opioid receptor, animal models
- MeSH terms
- Analgesics, Animals, Antineoplastic Agents, Phytogenic, Disease Models, Animal, Enkephalins, Hot Temperature, Hyperalgesia, Injections, Intravenous, Male, Neurons, Afferent, Peripheral Nervous System Diseases, Physical Stimulation, Psychomotor Performance, Vincristine, Rats, Sprague-Dawley, Pain Threshold, Enkephalin, Ala(2)-MePhe(4)-Gly(5)-, Rats
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