Pain related behaviour during vincristine-induced neuropathy in rats
Abstract
The development of suitable animal models of neuropathic pain is essential to understand the pathophysiological mechanisms responsible for this condition. This study presents the alterations in nociception observed in rats suffering from a peripheral neuropathy induced by 10 daily repeated intravenous injections of vincristine at doses of 50 or 75 microg/kg (total dose 500 or 750 microg/ kg). The rats present both mechanical hyperalgesia, allodynia and a loss of sensitivity (thermal hypoalgesia). Conservation of good health, the fast appearance of symptoms which correspond well with human responses and the easy induction of nociceptive symptoms are favourable criteria for using this model at 50 microg/kg vincristine dose in the future.
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In rats, 10 daily injections of vincristine (0.02, 0.1, or 0.2 mg/kg, intravenous) with a 2-day drug-free interval after the fifth day induced hyperalgesia and allodynia.
“In rats, 10 daily injections of vincristine (0.02, 0.1, or 0.2 mg/kg, intravenous) with a 2-day drug-free interval after the fifth day, induced hyperalgesia (Aley et al, 1996), and allodynia (Authier et al, 1999).”
From The endogenous cannabinoid system: a budding source of targets for treating inflammatory and neuropathic pain (2018) · cites this paper as Authier et al, 1999
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- Authors
- Authier, N., Coudore, F., Eschalier, A., & Fialip, J.
- Affiliations
- Université Clermont Auvergne (FR)
- Venue
- NeuroReport
- Published
- 1999-04
- Volume
- 10
- Issue
- 5
- Pages
- 965-968
- ISSN
- 0959-4965 (ISSN-L)
- OpenAlex
- W2057710964
- Cited by
- 77
- References
- 9
- Citations by year
- 2024: 1 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 4 · 2019: 2 · 2018: 1 · 2017: 4 · 2016: 2 · 2015: 4 · 2014: 2 · 2013: 4 · 2012: 1
- FWCI
- 1.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroreport (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Oncology › Cancer Treatment and Pharmacology
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Keywords
- vincristine, chemotherapy-induced peripheral neuropathy, neuropathic pain, mechanical hyperalgesia, allodynia, thermal hypoalgesia, nociception
- MeSH terms
- Animals, Behavior, Animal, Dose-Response Relationship, Drug, Hyperalgesia, Hypesthesia, Male, Nociceptors, Pain, Peripheral Nervous System Diseases, Physical Stimulation, Vincristine, Rats, Sprague-Dawley, Pain Threshold, Rats
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