Cited by 77Pain Mechanisms and TreatmentsCancer Treatment and PharmacologyIon Channels and Receptors

Pain related behaviour during vincristine-induced neuropathy in rats

Authier, Nicolas, Coudore, François, Eschalier, Alain, Fialip, Joseph·1999·NeuroReport

Abstract

The development of suitable animal models of neuropathic pain is essential to understand the pathophysiological mechanisms responsible for this condition. This study presents the alterations in nociception observed in rats suffering from a peripheral neuropathy induced by 10 daily repeated intravenous injections of vincristine at doses of 50 or 75 microg/kg (total dose 500 or 750 microg/ kg). The rats present both mechanical hyperalgesia, allodynia and a loss of sensitivity (thermal hypoalgesia). Conservation of good health, the fast appearance of symptoms which correspond well with human responses and the easy induction of nociceptive symptoms are favourable criteria for using this model at 50 microg/kg vincristine dose in the future.

Integrity signals

Registry

Crossref · 10.1097/00001756-199904060-00013

Cites

9 of 9 references verified0 citation errors · 0 not checkable

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  • In rats, 10 daily injections of vincristine (0.02, 0.1, or 0.2 mg/kg, intravenous) with a 2-day drug-free interval after the fifth day induced hyperalgesia and allodynia.

    “In rats, 10 daily injections of vincristine (0.02, 0.1, or 0.2 mg/kg, intravenous) with a 2-day drug-free interval after the fifth day, induced hyperalgesia (Aley et al, 1996), and allodynia (Authier et al, 1999).”

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Authors
Authier, N., Coudore, F., Eschalier, A., & Fialip, J.
Affiliations
Université Clermont Auvergne (FR)
Venue
NeuroReport
Published
1999-04
Volume
10
Issue
5
Pages
965-968
ISSN
0959-4965 (ISSN-L)
OpenAlex
W2057710964
Cited by
77
References
9
Citations by year
2024: 1 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 4 · 2019: 2 · 2018: 1 · 2017: 4 · 2016: 2 · 2015: 4 · 2014: 2 · 2013: 4 · 2012: 1
FWCI
1.86
Type
journal article
Language
en
Open access
closed
Locations
  • Neuroreport (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
  • Health Sciences › Medicine › Oncology › Cancer Treatment and Pharmacology
  • Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
Keywords
vincristine, chemotherapy-induced peripheral neuropathy, neuropathic pain, mechanical hyperalgesia, allodynia, thermal hypoalgesia, nociception
MeSH terms
Animals, Behavior, Animal, Dose-Response Relationship, Drug, Hyperalgesia, Hypesthesia, Male, Nociceptors, Pain, Peripheral Nervous System Diseases, Physical Stimulation, Vincristine, Rats, Sprague-Dawley, Pain Threshold, Rats

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