The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Blockade of the LH surge and ovulation by GABA-T inhibitory drugs that increase brain GABA levels in rats
Abstract
The present experiments were designed to evaluate the effects of GABA increase in the brain on the LH surge and ovulation in female rats. GABA-transaminase (GABA-T) inhibitory drugs were administered intraperitoneally in the early afternoon hours on the day before the expected ovulation. Gamma-acetylenic GABA (GAG) prevented the proestrus LH surge and ovulation in freely moving adult female rats. In a similar manner, GAG blunted the enhanced LH release found at 1800 h on the preovulatory day and the subsequent ovulation in PMSG-treated 32-day-old rats. LH secretion and ovulation in these animals was restored by administration of the selective GABA antagonist, bicuculline. The other GABA-T inhibitors, amino-oxyacetic acid and gamma-vinyl GABA, produced similar effects to GAG in the PMSG-treated rats. These results indicate that the increase of brain GABA levels during the preovulatory day alters LH release and prevents ovulation in rats.
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“and that its occurrence is coincident with a decline of GABAergic transmission to both POA kisspeptin neurons and GnRH neurons [106,107].”
From Fibromyalgia pathogenesis explained by a neuroendocrine multistable model (2024) · cites this paper as [106]
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Cites
Jung, M. J., Lippert, B. J., Metcalf, B. W., Böhlen, P., & Schechter, P. J. (1977) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1977.tb10721.x · Cited by 481
Barraclough, C. A., & Wise, P. M. (1982) · Endocrine Reviews · doi:10.1210/edrv-3-1-91 · Cited by 371
GABA Neuron Systems in Hypothalamus and the Pituitary Gland
Vincent, S. R., Hökfelt, T. G. M., & Wu, J. (2008) · Neuroendocrinology · doi:10.1159/000123288 · Cited by 311
Progress in Psychoneuroendocrinology
Carroll, B. J. (1982) · Psychoneuroendocrinology · doi:10.1016/0306-4530(82)90058-0 · Cited by 293
Andrews, P. R., & Johnston, G. A. R. (1979) · Biochemical Pharmacology · doi:10.1016/0006-2952(79)90549-5 · Cited by 223
de la Mora, M. P., Possani, L. D., Tapia, R., Teran, L. M., Palacios, R., Fuxé, K., Ho¨kfelt, T., & Ljungdahl, Å. (1981) · Neuroscience · doi:10.1016/0306-4522(81)90169-x · Cited by 167
Vijayan, E., & McCann, S. M. (1978) · Brain Research · doi:10.1016/0006-8993(78)90303-7 · Cited by 149
Gamma-Aminobutyric Acid Effects on Pituitary Gonadotropin Secretion
Ondo, J. G. (1974) · Science · doi:10.1126/science.186.4165.738 · Cited by 122
Löscher, W. (1981) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1981.tb00595.x · Cited by 99
The Effects of γ-Aminobutyric Acid on Prolactin and Gonadotropin Secretion in the Unanesthetized Rat
Pass, K. A., & Ondo, J. G. (1977) · Endocrinology · doi:10.1210/endo-100-5-1437 · Cited by 96
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Sorted by citations
Grant, S., & Heel, R. C. (1991) · Drugs · doi:10.2165/00003495-199141060-00007 · Cited by 311
Neuroendocrine Control of the Ovarian Cycle of the Rat
Freeman, M. R. (2006) · Elsevier eBooks · doi:10.1016/b978-012515400-0/50048-8 · Cited by 287
Chapter 2 Hypothalamic Neural Systems Controlling the Female Reproductive Life Cycle
(2009) · International Review of Cell and Molecular Biology · doi:10.1016/s1937-6448(08)02002-9 · Cited by 93
MASOTTO, C., Wisniewski, G., & Negro-Vilar, A. F. (1989) · Endocrinology · doi:10.1210/endo-125-1-548 · Cited by 64
MASOTTO, C., & Negro-Vilar, A. F. (1987) · Endocrinology · doi:10.1210/endo-121-6-2251 · Cited by 44
Ferreira, S. A., Scott, C., Kuehl, D. E., & Jackson, G. L. (1996) · Endocrinology · doi:10.1210/en.137.8.3453 · Cited by 40
Unraveling the connection between GABA and kisspeptin in the control of reproduction
Giorgio, N. P. D., Bizzozzero-Hiriart, M., Libertun, C., & Lux-Lantos, V. A. (2019) · Reproduction · doi:10.1530/rep-18-0527 · Cited by 33
Funabashi, T., Jinnai, K., & Kimura, F. (1997) · Neuroreport · doi:10.1097/00001756-199702100-00038 · Cited by 31
Leonhardt, S., Böning, B., Luft, H., Wuttke, W., & Jarry, H. (2000) · Neuroendocrinology · doi:10.1159/000054515 · Cited by 24
Akema, T., & Kimura, F. (1991) · Brain Research · doi:10.1016/0006-8993(91)91203-d · Cited by 21
Gonadotropin-releasing hormone (GnRH) surge generator in female rats
Funabashi, T., Mitsushima, D., Nakamura, T. J., Uemura, T., Hirahara, F., Shinohara, K., Suyama, K., & Kimura, F. (2002) · Progress in brain research · doi:10.1016/s0079-6123(02)41091-6 · Cited by 15
Rey-Roldán, E. B., Lux-Lantos, V. A., González-Iglesias, A. E., Becú‐Villalobos, D., & Libertun, C. (1996) · Life Sciences · doi:10.1016/0024-3205(96)00059-8 · Cited by 15
Fibromyalgia pathogenesis explained by a neuroendocrine multistable model
Demori, I., Losacco, S., Giordano, G., Mucci, V., Blanchini, F., & Burlando, B. (2024) · PLOS ONE · doi:10.1371/journal.pone.0303573 · Cited by 14
Brann, D. W., Unda, R., & Mahesh, V. B. (2002) · Neuroendocrinology · doi:10.1159/000066628 · Cited by 12
GABA control of LHRH release is dependent on the steroid milieu
McRee, R., & Meyer, D. C. (1993) · Neuroscience Letters · doi:10.1016/0304-3940(93)90743-5 · Cited by 11
Bizzozzero-Hiriart, M., Giorgio, N. P. D., Libertun, C., & Lux-Lantos, V. A. (2020) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00547.2019 · Cited by 6
Giorgio, N. P. D., Bizzozzero-Hiriart, M., Surkin, P. N., Repetto, E. M., Bonaventura, M. M., Tabares, F. N., Bourguignon, N. S., Converti, A., Gómez, J. M. R., Bettler, B., et al. (2023) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00129.2022 · Cited by 3
Vieira, H. R., Ferrufino, E. G., de Sousa, L. M. M., Alves, G. A., MARTINS, M., Donato, J., & Frazão, R. (2026) · Frontiers in Endocrinology · doi:10.3389/fendo.2026.1807596 · Cited by 1
Stress and the hypothalamus-pituitary-gonadal axis in the cyclic rat
Roozendaal, M. M. (1997) · doi:10.18174/210507 · Cited by 1
Metadata
- Authors
- Donoso, A. O., & Banzan, A. M.
- Affiliations
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- Corresponding author
- Donoso, A.O.
- Venue
- Psychoneuroendocrinology
- Publisher
- Elsevier BV
- Published
- 1986-01
- Volume
- 11
- Issue
- 4
- Pages
- 429-435
- ISSN
- 0306-4530 (ISSN-L)
- OpenAlex
- W1980560986
- Cited by
- 19
- References
- 26
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 1 · 2020: 1 · 2019: 1
- FWCI
- 0.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychoneuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- GABA transaminase inhibitors, gamma-acetylenic GABA, brain GABA, luteinizing hormone surge, ovulation, bicuculline, aminooxyacetic acid, vigabatrin, permanent magnet synchronous generator, female reproduction, luteinizing hormone secretion
- MeSH terms
- Alkynes, 4-Aminobutyrate Transaminase, Aminocaproates, Animals, Bicuculline, Brain Chemistry, Estrus, Female, gamma-Aminobutyric Acid, Gonadotropins, Equine, Luteinizing Hormone, Ovulation, Rats
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