Homologous physiological effects of phenformin and chromium picolinate
Abstract
The insulin-sensitizing drug phenformin, in addition to its clinical utility in type II diabetes, has been reported to lower blood lipids, reduce body fat, enhance cellular immunity, and--in rodents--to increase mean lifespan and retard the development of growth of cancer. Initial studies with the insulin-sensitizing nutrient chromium picolinate indicate that it aids glucose tolerance in type II diabetes, lowers elevated LDL cholesterol, reduces body fat while increasing lean mass, and--in rats--increases median lifespan. These effects are thus analogous to those reported for phenformin; chromium picolinate should be tested to determine whether it likewise has a favorable impact on cellular immunity and cancer risk. The ability of both phenformin and chromium picolinate to increase lifespan suggests that age-related insulin resistance may play a profound role in the aging process. It may not be coincidental that caloric restriction--the best documented technique for increasing lifespan--markedly increases insulin sensitivity. Safe, appropriate measures for promoting lifelong insulin sensitivity include a low-fat diet, exercise training, and supplemental chromium picolinate.
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Chromium picolinate improves insulin utilization and efficiency in humans and animals.
“Combining picolinate acid with chromium in the form of chromium picolinate (CrP) enhances the bioavailability of chromium compared to other salts of chromium, and by doing so improves insulin utilization and efficiency in humans and animals [10].”
From Body Composition Changes in Weight Loss: Strategies and Supplementation for Maintaining Lean Body Mass, a Brief Review (2018) · cites this paper as [10]
Combining picolinic acid with chromium in the form of chromium picolinate enhances the bioavailability of chromium compared to other salts of chromium.
“Combining picolinate acid with chromium in the form of chromium picolinate (CrP) enhances the bioavailability of chromium compared to other salts of chromium, and by doing so improves insulin utilization and efficiency in humans and animals [10].”
From Body Composition Changes in Weight Loss: Strategies and Supplementation for Maintaining Lean Body Mass, a Brief Review (2018) · cites this paper as [10]
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السهیل, م. ص. ز. (2021) · المجلة العلمیة للتربیة البدنیة وعلوم الریاضة جامعة حلوان · doi:10.21608/jsbsh.2021.93160.1848
- Authors
- McCarty, M. F.
- Affiliations
- Nutrition 21 (United States) (US)
- Corresponding author
- McCarty, M.F.
- ORCID
- McCarty, M.F.
- Venue
- Medical Hypotheses
- Publisher
- Elsevier BV
- Published
- 1993-10
- Volume
- 41
- Issue
- 4
- Pages
- 316-324
- ISSN
- 0306-9877 (ISSN-L)
- OpenAlex
- W2089167671
- Cited by
- 42
- References
- 74
- Citations by year
- 2021: 1 · 2019: 3 · 2018: 2 · 2016: 1 · 2015: 2 · 2012: 1
- FWCI
- 1.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Medical Hypotheses (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- phenformin, chromium picolinate, insulin sensitizers, type 2 diabetes, glucose tolerance, LDL cholesterol, fat mass, lifespan extension, aging, insulin resistance, caloric restriction, cell-mediated immunity, cancer risk, exercise training, low-fat diet
- MeSH terms
- Adipose Tissue, Aging, Animals, Brain, Humans, Insulin Resistance, Longevity, Neoplasms, Experimental, Phenformin, Picolinic Acids, Receptors, Cell Surface, Rats
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