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Free radical activity associated with the surface of particles: a unifying factor in determining biological activity?
Abstract
Using a sensitive phi X174 RF plasmid DNA assay, free radical activity was detected at the surface of normal and ultrafine titanium dioxide (TiO2), environmental particles (PM-10), asbestos and a range of man-made fibres. There were differences in the amount of free radical activity that was detected, with ultrafine TiO2 being much more active than normal-sized TiO2; PM-10 also had substantial free radical activity. Amphibole asbestos samples were highly active, whilst man-made fibres were much less active than asbestos. For all of the particles, the DNA damage could be ameliorated by mannitol, showing that hydroxyl radicals were involved. The ability of particles to generate free radicals at or near their surface, and thereby impose oxidant stress in key target cells, could be central to determining their pathogenicity.
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“The generation of free radicals and inflammatory cytokines by phagocytic and other cell types was continued to be investigated [357–360] and the relationship between this property and their toxicity and pathogenicity was established [361–364]”
From Particle toxicology and health - where are we? (2019) · cites this paper as [364]
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Donaldson, K., Aitken, R., Tran, L., Stone, V., Duffin, R., Forrest, G., & Alexander, A. (2006) · Toxicological Sciences · doi:10.1093/toxsci/kfj130 · Cited by 1,167
Self-citationNanotechnology in cosmetics: Opportunities and challenges
Raj, S., Jose, S., Sumod, U., & Sabitha, M. (2012) · Journal of Pharmacy And Bioallied Sciences · doi:10.4103/0975-7406.99016 · Cited by 545
de Kok, T. M. C. M., Driece, H. A. L., Hogervorst, J. G. F., & Briedé, J. J. (2006) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2006.07.001 · Cited by 489
Particle toxicology and health - where are we?
Riediker, M., Zink, D., Kreyling, W., Oberdörster, G., Elder, A., Graham, U., Lynch, I., Duschl, A., Ichihara, G., Ichihara, S., et al. (2019) · Particle and Fibre Toxicology · doi:10.1186/s12989-019-0302-8 · Cited by 237
The asbestos-carbon nanotube analogy: An update
Kane, A. B., Hurt, R. H., & Gao, H. (2018) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2018.06.027 · Cited by 106
Metadata
- Authors
- Donaldson, K.
- Venue
- Toxicology Letters
- Publisher
- Elsevier BV
- Published
- 1996-11
- Volume
- 88
- Issue
- 1-3
- Pages
- 293-298
- ISSN
- 0378-4274
- Cited by
- 227
- References
- 0
- Language
- en
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- Donaldson, K. (1996). Free radical activity associated with the surface of particles: a unifying factor in determining biological activity? Toxicology Letters. https://doi.org/10.1016/0378-4274(96)03752-6
