Toxicological assessment of ambient and traffic-related particulate matter: A review of recent studies

de Kok, Theo M.C.M.; Driece, Hermen A.L.; Hogervorst, Janneke G.F.; Briedé, Jacob J.

doi:10.1016/j.mrrev.2006.07.001

Cited by 489Air Quality and Health ImpactsCarcinogens and Genotoxicity AssessmentIndoor Air Quality and Microbial Exposure

Toxicological assessment of ambient and traffic-related particulate matter: A review of recent studies

de Kok, Theo M.C.M., Driece, Hermen A.L., Hogervorst, Janneke G.F., Briedé, Jacob J.·2006·Mutation Research/Reviews in Mutation Research

DOI 10.1016/j.mrrev.2006.07.001

Open this paper in CoChat — free account

Abstract

Particulate air pollution (PM) is an important environmental health risk factor for many different diseases. This is indicated by numerous epidemiological studies on associations between PM exposure and occurrence of acute respiratory infections, lung cancer and chronic respiratory and cardiovascular diseases. The biological mechanisms behind these associations are not fully understood, but the results of in vitro toxicological research have shown that PM induces several types of adverse cellular effects, including cytotoxicity, mutagenicity, DNA damage and stimulation of proinflammatory cytokine production. Because traffic is an important source of PM emission, it seems obvious that traffic intensity has an important impact on both quantitative and qualitative aspects of ambient PM, including its chemical, physical and toxicological characteristics. In this review, the results are summarized of the most recent studies investigating physical and chemical characteristics of ambient and traffic-related PM in relation to its toxicological activity. This evaluation shows that, in general, the smaller PM size fractions (<PM(10)) have the highest toxicity, contain higher concentrations of extractable organic matter (comprising a wide spectrum of chemical substances), and possess a relatively high radical-generating capacity. Also, associations between chemical characteristics and PM toxicity tend to be stronger for the smaller PM size fractions. Most importantly, traffic intensity does not always explain local differences in PM toxicity, and these differences are not necessarily related to PM mass concentrations. This implies that PM regulatory strategies should take PM-size fractions smaller than PM(10) into account. Therefore, future research should aim at establishing the relationship between toxicity of these smaller fractions in relation to their specific sources.

Integrity signals

Registry

Crossref · 10.1016/j.mrrev.2006.07.001

Cites

107 of 107 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Smaller particles have the ability to penetrate into the circulatory system and are thought to be more biologically active.
“Because smaller particles have the ability to penetrate into the circulatory system and are thought to be more biologically active [83–86]”
From A Systematic Review and Meta-Analysis of Multiple Airborne Pollutants and Autism Spectrum Disorder (2016) · cites this paper as [84]

IARC monographs on the evaluation of carcinogenic risks to humans
Hopkins, J. C. A. (1989) · Food and Chemical Toxicology · doi:10.1016/0278-6915(89)90054-9 · Cited by 2,868 · see citing works
Fine Particulate Air Pollution and Mortality in 20 U.S. Cities, 1987–1994
Samet, J. M., Dominici, F., Curriero, F. C., Coursac, I., & Zeger, S. L. (2000) · New England Journal of Medicine · doi:10.1056/nejm200012143432401 · Cited by 2,235 · see citing works
Ultrafine particulate pollutants induce oxidative stress and mitochondrial damage
Li, N., Sioutas, C., Cho, A., Schmitz, D., Misra, C., Sempf, J., Wang, M., Oberley, T., Froines, J., & Nel, A. (2003) · Environmental Health Perspectives · doi:10.1289/ehp.6000 · Cited by 2,097 · see citing works
Fine Particulate Air Pollution and Mortality in 20 U.S. Cities
Sarnat, J. A., Schwartz, J. D., & Suh, H. H. (2001) · New England Journal of Medicine · doi:10.1056/nejm200104193441614 · Cited by 1,894 · see citing works
Air quality guidelines for Europe
Lodge, J. P. (1988) · Atmospheric Environment (1967) · doi:10.1016/0004-6981(88)90109-6 · Cited by 1,806 · see citing works
Sources of fine organic aerosol. 2. Noncatalyst and catalyst-equipped automobiles and heavy-duty diesel trucks
Rogge, W. F., Hildemann, L. M., Mazurek, M. A., Cass, G. R., & Simoneit, B. R. T. (1993) · Environmental Science & Technology · doi:10.1021/es00041a007 · Cited by 1,421 · see citing works
Air quality guidelines for Europe.
(2000) · PubMed · Cited by 1,324 · see citing works
Tropospheric Air Pollution: Ozone, Airborne Toxics, Polycyclic Aromatic Hydrocarbons, and Particles
Finlayson‐Pitts, B. J., & PITTS, J. N. J. (1997) · Science · doi:10.1126/science.276.5315.1045 · Cited by 1,201 · see citing works
Cancer risk from occupational and environmental exposure to polycyclic aromatic hydrocarbons
Boffetta, P., Jourenkova, N., & Gustavsson, P. (1997) · Cancer Causes & Control · doi:10.1023/a:1018465507029 · Cited by 1,039 · see citing works
Reactive oxygen species (ROS) and reactive nitrogen species (RNS) generation by silica in inflammation and fibrosis
Fubini, B., & Hubbard, A. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(03)00149-7 · Cited by 935 · see citing works
Fine particles and human health—a review of epidemiological studies
Englert, N. (2004) · Toxicology Letters · doi:10.1016/j.toxlet.2003.12.035 · Cited by 674 · see citing works
On-Road Emissions of Particulate Polycyclic Aromatic Hydrocarbons and Black Carbon from Gasoline and Diesel Vehicles
Miguel, A. H., Kirchstetter, T. W., Harley, R. A., & Hering, S. V. (1998) · Environmental Science & Technology · doi:10.1021/es970566w · Cited by 541 · see citing works
Role of Free Radicals in the Toxicity of Airborne Fine Particulate Matter
Dellinger, B., Pryor, W. A., Cueto, R., Squadrito, G. L., Hegde, V. K., & Deutsch, W. A. (2001) · Chemical Research in Toxicology · doi:10.1021/tx010050x · Cited by 533 · see citing works
Health effects of particles in ambient air
Kappos, A. D., Brückmann, P., Eikmann, T. F., Englert, N., Heinrich, U., Höppe, P., Koch, E., Krause, G. H. M., Kreyling, W. G., Rauchfuss, K., et al. (2004) · International Journal of Hygiene and Environmental Health · doi:10.1078/1438-4639-00306 · Cited by 498 · see citing works
Quinoid redox cycling as a mechanism for sustained free radical generation by inhaled airborne particulate matter
Squadrito, G. L., Cueto, R., Dellinger, B., & Pryor, W. A. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00703-1 · Cited by 481 · see citing works
Atmospheric chemistry of gas-phase polycyclic aromatic hydrocarbons: formation of atmospheric mutagens.
Atkinson, R., & Arey, J. (1994) · Environmental Health Perspectives · doi:10.1289/ehp.94102s4117 · Cited by 458 · see citing works
Trace Metal Concentrations and Water Solubility in Size-Fractionated Atmospheric Particles and Influence of Road Traffic
Birmili, W., Allen, A. G., Bary, F., & Harrison, R. M. (2006) · Environmental Science & Technology · doi:10.1021/es0486925 · Cited by 388 · see citing works
Subway Particles Are More Genotoxic than Street Particles and Induce Oxidative Stress in Cultured Human Lung Cells
Karlsson, H. L., Nilsson, L., & Möller, L. (2004) · Chemical Research in Toxicology · doi:10.1021/tx049723c · Cited by 338 · see citing works
Sensitive method for the detection of mutagenic nitroarenes and aromatic amines: new derivatives of Salmonella typhimurium tester strains possessing elevated O-acetyltransferase levels
Watanabe, M., Ishidate, M., & Nohmi, T. (1990) · Mutation Research/Environmental Mutagenesis and Related Subjects · doi:10.1016/0165-1161(90)90044-o · Cited by 320 · see citing works
Insights into the Chemistry of New Particle Formation and Growth Events in Pittsburgh Based on Aerosol Mass Spectrometry
Zhang, Q. I., Stanier, C. O., Canagaratna, M. R., et al. (2004) · Environmental Science & Technology · doi:10.1021/es035417u · Cited by 297 · see citing works
Traffic contribution of polycyclic aromatic hydrocarbons in the center of a large city
Nielsen, T. (1996) · Atmospheric Environment · doi:10.1016/1352-2310(96)00096-9 · Cited by 294 · see citing works
Free radical activity associated with the surface of particles: a unifying factor in determining biological activity?
Donaldson, K. (1996) · Toxicology Letters · doi:10.1016/0378-4274(96)03752-6 · Cited by 286 · see citing works
Products and Mechanism of Secondary Organic Aerosol Formation from Reactions ofn-Alkanes with OH Radicals in the Presence of NOx
Lim, Y. B., & Ziemann, P. J. (2005) · Environmental Science & Technology · doi:10.1021/es051447g · Cited by 283 · see citing works
Metal-rich Ambient Particles (Particulate Matter2.5) Cause Airway Inflammation in Healthy Subjects
Schaumann, F., Borm, P. J. A., Herbrich, A., Knoch, J., Pitz, M., Schins, R. P. F., Luettig, B., Hohlfeld, J. M., Heinrich, J., & Krug, N. (2004) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200403-423oc · Cited by 276 · see citing works
The role of metals in site-specific DNA damage with reference to carcinogenesis1,2 1Guest Editor: Miral Dizdaroglu 2This article is part of a series of reviews on “Oxidative DNA Damage and Repair.” The full list of papers may be found on the homepage of the journal.
Kawanishi, S., Hiraku, Y., Murata, M., & Oikawa, S. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00779-7 · Cited by 271 · see citing works
Use of a stratified oxidative stress model to study the biological effects of ambient concentrated and diesel exhaust particulate matter
Li, N., Kim, S., Wang, M., Froines, J., Sioutas, C., & Nel, A. (2002) · Inhalation Toxicology · doi:10.1080/089583701753678571 · Cited by 249 · see citing works
Linking exposure to environmental pollutants with biological effects
Sørensen, M., Autrup, H. N., Möller, P., Hertel, O., Jensen, S. S., Vinzents, P. S., Knudsen, L. E., & Loft, S. H. (2003) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2003.06.010 · Cited by 237 · see citing works
Electron paramagnetic resonance study of the generation of reactive oxygen species catalysed by transition metals and quinoid redox cycling by inhalable ambient particulate matter
Valavanidis, A., Fiotakis, K., Bakeas, E. B., & Vlahogianni, T. (2005) · Redox Report · doi:10.1179/135100005x21606 · Cited by 233 · see citing works
Free radical activity of PM10: iron-mediated generation of hydroxyl radicals.
Donaldson, K., Brown, D. M., Mitchell, C., Dineva, M., Beswick, P. H., Gilmour, P. S., & MacNee, W. (1997) · Environmental Health Perspectives · doi:10.1289/ehp.97105s51285 · Cited by 227 · see citing works
Adverse health effects of PM10 particles: involvement of iron in generation of hydroxyl radical.
Gilmour, P. S., Brown, D. M., Lindsay, T. G., Beswick, P. H., MacNee, W., & Donaldson, K. (1996) · Occupational and Environmental Medicine · doi:10.1136/oem.53.12.817 · Cited by 216 · see citing works
Soluble metals as well as the insoluble particle fraction are involved in cellular DNA damage induced by particulate matter
Knaapen, A. M., Shi, T., Borm, P. J. A., & Schins, R. P. F. (2002) · Molecular and Cellular Biochemistry · doi:10.1023/a:1015970023889 · Cited by 211 · see citing works
Hydroxyl radical generation by electron paramagnetic resonance as a new method to monitor ambient particulate matter composition
Shi, T., Schins, R. P. F., Knaapen, A. M., Kuhlbusch, T. A. J., Pitz, M., Heinrich, J., & Borm, P. J. A. (2003) · Journal of Environmental Monitoring · doi:10.1039/b303928p · Cited by 209 · see citing works
The genotoxicity of ambient outdoor air, a review: Salmonella mutagenicity
Claxton, L. D., Matthews, P. P., & Warren, S. H. (2004) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2004.08.002 · Cited by 206 · see citing works
METALS ASSOCIATED WITH BOTH THE WATER-SOLUBLE AND INSOLUBLE FRACTIONS OF AN AMBIENT AIR POLLUTION PARTICLE CATALYZE AN OXIDATIVE STRESS
Ghio, A. J. (1999) · Inhalation Toxicology · doi:10.1080/089583799197258 · Cited by 205 · see citing works
Air Pollution Particles Mediated Oxidative DNA Base Damage in a Cell Free System and in Human Airway Epithelial Cells in Relation to Particulate Metal Content and Bioreactivity
Prahalad, A. K., Inmon, J., Dailey, L. A., Madden, M. C., Ghio, A. J., & Gallagher, J. E. (2001) · Chemical Research in Toxicology · doi:10.1021/tx010022e · Cited by 205 · see citing works
Health Risk Assessment of Urban Suspended Particulate Matter with Special Reference to Polycyclic Aromatic Hydrocarbons: A Review
RAVINDRA, R., Mittal, A. K., & Grieken, R. V. (2001) · Reviews on Environmental Health · doi:10.1515/reveh.2001.16.3.169 · Cited by 198 · see citing works
Particulate Matter Induces Alveolar Epithelial Cell DNA Damage and Apoptosis
Upadhyay, D., Panduri, V., Ghio, A. J., & Kamp, D. W. (2003) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2002-0269oc · Cited by 191 · see citing works
Biologic effects induced in vitro by PM10 from three different zones of Mexico City.
Alfaro‐Moreno, E., Martínez, L., García-Cuellar, C. M., Bonner, J. C., Murray, J. C., Rosas, I., Rosales, S. P. D. L., & Osornio-Vargas, Á. R. (2002) · Environmental Health Perspectives · doi:10.1289/ehp.02110715 · Cited by 191 · see citing works
Ambient Air Particles: Effects on Cellular Oxidant Radical Generation in Relation to Particulate Elemental Chemistry
Prahalad, A. K., Soukup, J. M., Inmon, J., Willis, R. D., Ghio, A. J., Becker, S., & Gallagher, J. E. (1999) · Toxicology and Applied Pharmacology · doi:10.1006/taap.1999.8701 · Cited by 173 · see citing works
A sensitive method for the detection of mutagenic nitroarenes: construction of nitroreductase-overproducing derivatives of Salmonella typhimurium strains TA98 and TA100
Watanabe, M., Ishidate, M., & Nohmi, T. (1989) · Mutation Research/Environmental Mutagenesis and Related Subjects · doi:10.1016/0165-1161(89)90007-1 · Cited by 171 · see citing works
Inhaled Concentrated Ambient Particles Are Associated with Hematologic and Bronchoalveolar Lavage Changes in Canines
Clarke, R. W., Coull, B. A., Reinisch, U., Catalano, P. J., Killingsworth, C. R., Koutrakis, P., Kavouras, I. G., Murthy, G. G. K., Lawrence, J. E., Lovett, E. G., et al. (2000) · Environmental Health Perspectives · doi:10.1289/ehp.001081179 · Cited by 168 · see citing works
Temporal variation of hydroxyl radical generation and 8-hydroxy-2′-deoxyguanosine formation by coarse and fine particulate matter
Shi, T., Knaapen, A. M., Begerow, J., Birmili, W., Borm, P. J. A., & Schins, R. P. F. (2003) · Occupational and Environmental Medicine · doi:10.1136/oem.60.5.315 · Cited by 158 · see citing works
Pulmonary dysfunction in cystic fibrosis is associated with oxidative stress
Brown, R., Wyatt, H., Price, J., & Kelly, F. (1996) · European Respiratory Journal · doi:10.1183/09031936.96.09020334 · Cited by 152 · see citing works
Noninvasive detection of hydroxyl radical generation in lung by diesel exhaust particles
Han, J.-Y., Takeshita, K., & Utsumi, H. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00501-3 · Cited by 148 · see citing works
Heterogeneity of Platinum Group Metals in Airborne Particles
Rauch, S., Lu, M. X., & Morrison, G. M. (2000) · Environmental Science & Technology · doi:10.1021/es000048c · Cited by 147 · see citing works
Biological activities of organic compounds adsorbed onto ambient air particles: comparison between the cities of Teplice and Prague during the summer and winter seasons 2000–2001
Binková, B., Černá, M., Pastorková, A., et al. (2003) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(02)00312-3 · Cited by 130 · see citing works
Characterization of particulate, metallic elements of TSP, PM2.5 and PM2.5-10 aerosols at a farm sampling site in Taiwan, Taichung
Fang, G., Chang, C., Chu, C., et al. (2003) · The Science of The Total Environment · doi:10.1016/s0048-9697(02)00648-4 · Cited by 127 · see citing works
Atmospheric Chemistry of Gas-Phase Polycyclic Aromatic Hydrocarbons: Formation of Atmospheric Mutagens
Atkinson, R., & Arey, J. (1994) · Environmental Health Perspectives · doi:10.2307/3431940 · Cited by 127 · see citing works
Particle-bound PAH content in ambient air
Sheu, H., Lee, W., Lin, S. J., et al. (1997) · Environmental Pollution · doi:10.1016/s0269-7491(97)00044-4 · Cited by 118 · see citing works
Elemental characterization of PM10, PM2.5 and PM1 in the town of Genoa (Italy)
Ariola, V., D’Alessandro, A., Lucarelli, F., et al. (2005) · Chemosphere · doi:10.1016/j.chemosphere.2005.05.004 · Cited by 117 · see citing works
Physicochemical Characteristics and Biological Activities of Seasonal Atmospheric Particulate Matter Sampling in Two Locations of Paris
Baulig, A., Poirault, J.-J., Ausset, P., Schins, R. P. F., Shi, T., Baralle, D., Dorlhène, P., Meyer, M., Lefèvre, R. A., Baeza‐Squiban, A., et al. (2004) · Environmental Science & Technology · doi:10.1021/es049476z · Cited by 115 · see citing works
Changes in elemental composition and mass of atmospheric aerosol pollution between 1996 and 2002 in a Central European city
Salma, I., & Maenhaut, W. (2006) · Environmental Pollution · doi:10.1016/j.envpol.2005.11.042 · Cited by 112 · see citing works
Cytotoxicity of PM2.5 and PM2.5–10 ambient air pollutants assessed by the MTT and the Comet assays
Hsiao, W. L. W., Mo, Z., 方明, Shi, X.-M., & Wang, F. (2000) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/s1383-5718(00)00116-9 · Cited by 104 · see citing works
Urban airborne particulate: genotoxicity evaluation of different size fractions by mutagenesis tests on microorganisms and comet assay
Buschini, A., Cassoni, F., Anceschi, E., et al. (2001) · Chemosphere · doi:10.1016/s0045-6535(00)00550-6 · Cited by 100 · see citing works
Genotoxicity and physicochemical characteristics of traffic‐related ambient particulate matter
de Kok, T. M. C. M., Hogervorst, J. G. F., Briedé, J. J., et al. (2005) · Environmental and Molecular Mutagenesis · doi:10.1002/em.20133 · Cited by 99 · see citing works
Self-citation
The role of combustion-generated radicals in the toxicity of PM2.5
Dellinger, B., Pryor, W. A., Cueto, R., Squadrito, G. L., & Deutsch, W. A. (2000) · Proceedings of the Combustion Institute · doi:10.1016/s0082-0784(00)80687-6 · Cited by 97 · see citing works
Comparative study of the formation of oxidative damage marker 8-hydroxy-2′-deoxyguanosine (8-OHdG) adduct from the nucleoside 2′-deoxyguanosine by transition metals and suspensions of particulate matter in relation to metal content and redox reactivity
Valavanidis, A., Vlahoyianni, T., & Fiotakis, K. (2005) · Free Radical Research · doi:10.1080/10715760500188671 · Cited by 93 · see citing works
Free Radical Activity of PM 10 : Iron-Mediated Generation of Hydroxyl Radicals
Donaldson, K., Brown, D. M., Mitchell, C., Dineva, M., Beswick, P. H., Gilmour, P. S., & MacNee, W. (1997) · Environmental Health Perspectives · doi:10.2307/3433548 · Cited by 92 · see citing works
Exhaust emissions from light- and heavy-duty vehicles: chemical composition, impact of exhaust after treatment, and fuel parameters.
Westerholm, R. N., & Egeback, K.-E. (1994) · Environmental Health Perspectives · doi:10.1289/ehp.94102s413 · Cited by 91 · see citing works
Respiratory muscle function and free radicals: from cell to COPD
Heunks, L. M. A. (2000) · Thorax · doi:10.1136/thorax.55.8.704 · Cited by 86 · see citing works
Particle-induced oxidative damage is ameliorated by pulmonary antioxidants
Greenwell, L. L., Moreno, T., Jones, T. P., & Richards, R. J. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00782-7 · Cited by 83 · see citing works
Genotoxicity of urban air pollutants in the Czech Republic
Topinka, J., Schwarz, L. R., Wiebel, F. J., et al. (2000) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/s1383-5718(00)00061-9 · Cited by 77 · see citing works
Inherent Redox Properties of Diesel Exhaust Particles: Catalysis of the Generation of Reactive Oxygen Species by Biological Reductants
Pan, C. G. (2004) · Toxicological Sciences · doi:10.1093/toxsci/kfh199 · Cited by 70 · see citing works
Genotoxicity of urban air pollutants in the Czech Republic
Černá, M., Pochmanová, D., Pastorková, A., et al. (2000) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/s1383-5718(00)00062-0 · Cited by 69 · see citing works
Correlation between the Amounts of Polycyclic Aromatic Hydrocarbons and Mutagenicity of Airborne Particulate Samples from Taichung City, Taiwan
Kuo, C. Y., Cheng, Y., Chen, C.-Y., et al. (1998) · Environmental Research · doi:10.1006/enrs.1998.3838 · Cited by 66 · see citing works
Genotoxicity of PM10 and extracted organics collected in an industrial, urban and rural area in Flanders, Belgium
Brits, E., Schoeters, G. E. R., & Verschaeve, L. (2004) · Environmental Research · doi:10.1016/j.envres.2004.03.006 · Cited by 65 · see citing works
Bioactivation of diesel exhaust particle extracts and their major nitrated polycyclic aromatic hydrocarbon components, 1-nitropyrene and dinitropyrenes, by human cytochromes P450 1A1, 1A2, and 1B1
Yamazaki, H., Hatanaka, N., Kizu, R., et al. (2000) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/s1383-5718(00)00138-8 · Cited by 65 · see citing works
Development and Application of an Electron Spin Resonance Spectrometry Method for the Determination of Oxygen Free Radical Formation by Particulate Matter
Briedé, J. J., de Kok, T. M. C. M., Hogervorst, J. G. F., et al. (2005) · Environmental Science & Technology · doi:10.1021/es0485311 · Cited by 64 · see citing works
Self-citation
Mutagenic nitroarenes, diesel emissions, particulate-induced mutations and cancer: an essay on cancer-causation by a moving target
Rosenkranz, H. S. (1996) · Mutation Research/Genetic Toxicology · doi:10.1016/0165-1218(95)00066-6 · Cited by 63 · see citing works
Genotoxicity of fractionated organic material in airborne particles from São Paulo, Brazil
Martinis, B. S. D., Kado, N. Y., de Carvalho, L. R. F., et al. (1999) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/s1383-5718(99)00151-5 · Cited by 63 · see citing works
Chemical and in vitro toxicologic characterization of wintertime and springtime urban-air particles with an aerodynamic diameter below 10 microm in Helsinki.
Salonen, R. O., Hälinen, A. I., Pennanen, A. S., et al. (2004) · PubMed · Cited by 60 · see citing works
A genotoxic assessment of environmental tobacco smoke using bacterial bioassays
Claxton, L. D., Morin, R. S., Hughes, T. J., et al. (1989) · Mutation Research/Genetic Toxicology · doi:10.1016/0165-1218(89)90022-0 · Cited by 58 · see citing works
Polycyclic aromatic hydrocarbons in ambient air particles in the city of Las Palmas de Gran Canaria
Castellano, A. V. (2003) · Environment International · doi:10.1016/s0160-4120(03)00003-5 · Cited by 57 · see citing works
Mutagenic activity as a parameter to assess ambient air quality for protection of the environment and human health
Vargas, V. M. F. (2003) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2003.06.020 · Cited by 56 · see citing works
Genotoxicity of environmental air pollution in three European cities: Prague, Košice and Sofia
Gábelová, A., Valovičová, Z., Horváthová, E., et al. (2004) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2004.05.014 · Cited by 55 · see citing works
Possible Role of Ascorbic Acid in the Oxidative Damage Induced by Inhaled Crystalline Silica Particles
Fenoglio, I., Martra, G., Coluccia, S., & Fubini, B. (2000) · Chemical Research in Toxicology · doi:10.1021/tx000125h · Cited by 54 · see citing works
Assessment of mutagenicity and toxicity of different‐size fractions of air particulates from La Plata, Argentina, and Leipzig, Germany
Massolo, L., Müller, A., Tueros, M. J., et al. (2002) · Environmental Toxicology · doi:10.1002/tox.10054 · Cited by 54 · see citing works
Distribution of nitropyrenes and mutagenicity in airborne particulates collected with an Andersen sampler
Hayakawa, K., Kawaguchi, Y., Murahashi, T., et al. (1995) · Mutation Research Letters · doi:10.1016/0165-7992(95)00046-1 · Cited by 54 · see citing works
Particulate matter, PM 10 & PM 2.5 levels, and airborne mutagenicity in Chiang Mai, Thailand
Vinitketkumnuen, U., Kalayanamitra, K., Chewonarin, T., et al. (2002) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/s1383-5718(02)00130-4 · Cited by 53 · see citing works
Mutagenicity of airborne particulate organic material from urban and industrial areas of São Paulo, Brazil
Sato, M. I. Z., Umbuzeiro, G. D. A., Coimbrão, C. A., et al. (1995) · Mutation Research/Environmental Mutagenesis and Related Subjects · doi:10.1016/0165-1161(95)00035-6 · Cited by 50 · see citing works
Mutagenic activity of airborne particulate matter as an indicative measure of atmospheric pollution
Ducatti, A., & Vargas, V. M. F. (2003) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/s1383-5718(03)00170-0 · Cited by 49 · see citing works
Determination of Source Contributions to Ambient PM2.5in Kaohsiung, Taiwan, Using a Receptor Model
Chen, K.-S., Lin, C., & Chou, Y.-M. (2001) · Journal of the Air & Waste Management Association · doi:10.1080/10473289.2001.10464287 · Cited by 49 · see citing works
Traffic-related platinum and rhodium concentrations in the atmosphere of Rome
Bocca, B., Petrucci, F., Alimonti, A., et al. (2003) · Journal of Environmental Monitoring · doi:10.1039/b303732k · Cited by 49 · see citing works
Frameshift mutations: Relative roles of simple intercalation and of adduct formation
McCoy, E. C., Rosenkranz, E. J., Petrullo, L. A., et al. (1981) · Mutation Research/Genetic Toxicology · doi:10.1016/0165-1218(81)90047-1 · Cited by 46 · see citing works
The variation of street air levels of PAH and other mutagenic PAC in relation to regulations of traffic emissions and the impact of atmospheric processes
Nielsen, T., Feilberg, A., & Binderup, M. (1999) · Environmental Science and Pollution Research · doi:10.1007/bf02987613 · Cited by 45 · see citing works
Mutagenicity monitoring of airborne particulate matter (PM10) in the Czech Republic
Černá, M., Pastorková, A., Vrbı́ková, V., et al. (1999) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/s1383-5718(99)00107-2 · Cited by 43 · see citing works
Genotoxic and mutagenic activity of environmental air samples in Flanders, Belgium
Four, V. A. D., Larebeke, N. V., & Janssen, C. (2004) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2003.12.002 · Cited by 39 · see citing works
DNA binding of polycyclic aromatic hydrocarbons in a human bronchial epithelial cell line treated with diesel and gasoline particulate extracts and benzo[a]pyrene
Pohjola, S. K. (2003) · Mutagenesis · doi:10.1093/mutage/geg021 · Cited by 36 · see citing works
A comparative assessment of Boise, Idaho, ambient air fine particle samples using the plate and microsuspension Salmonella mutagenicity assays
Claxton, L. D., Warren, S. H., Zweidinger, R. B., et al. (2001) · The Science of The Total Environment · doi:10.1016/s0048-9697(00)00857-3 · Cited by 36 · see citing works
Genotoxicity of size-fractionated samples of urban particulate matter
Healey, K., Lingard, J. J. N., Tomlin, A. S., et al. (2005) · Environmental and Molecular Mutagenesis · doi:10.1002/em.20105 · Cited by 34 · see citing works
Genotoxic effects of a complex mixture adsorbed onto ambient air particles on human cells in vitro; the effects of Vitamins E and C
Lazarová, M., & Slameňová, D. (2003) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2003.10.011 · Cited by 33 · see citing works
Genotoxic activity of extractable organic matter from urban airborne particles in Shanghai, China
Zhao, X., Wan, Z., Chen, G., et al. (2002) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/s1383-5718(01)00338-2 · Cited by 32 · see citing works
Ability of Polymorphonuclear Leukocytes to Generate Active Oxygen Species in Children with Bronchial Asthma
Kato, M., Nakano, M., Morikawa, A., et al. (2009) · International Archives of Allergy and Applied Immunology · doi:10.1159/000235448 · Cited by 30 · see citing works
Composition and Origin of Airborne Particulate Matterin the Netherlands
Visser, H. J., Buringh, E., & van, B. P. (2001) · Cited by 29 · see citing works
Genotoxicity of organic extracts of airborne particles in somatic cells of Drosophila melanogaster
Delgado-Rodríguez, A., Ortíz-Martello, R., Villalobos‐Pietrini, R., et al. (1999) · Chemosphere · doi:10.1016/s0045-6535(98)00586-4 · Cited by 28 · see citing works
ROLE OF DNA REPAIR IN PARTICLE- AND FIBER-INDUCED LUNG INJURY
Hartwig, A. (2002) · Inhalation Toxicology · doi:10.1080/089583701753338659 · Cited by 25 · see citing works
Exhaust Emissions from Light- and Heavy-Duty Vehicles: Chemical Composition, Impact of Exhaust after Treatment, and Fuel Parameters
Westerholm, R. N., & Egebäck, K.-E. (1994) · Environmental Health Perspectives · doi:10.2307/3431926 · Cited by 20 · see citing works
Assessment of toxicity and mutagenicity in air particulate matter from an urban industrial area in the coast of the Rio de la Plata
Müller, A., Alzuet, P. R., Herbarth, O., et al. (2001) · Environmental Toxicology · doi:10.1002/tox.1019 · Cited by 15 · see citing works
THE MEASUREMENTS OF AMBIENT PARTICULATES (TSP, PM2.5, PM2.5–10), CHEMICAL COMPONENT CONCENTRATION VARIATION, AND MUTAGENICITY STUDY DURING 1998–2001 IN CENTRAL TAIWAN
Wu, Y., Fang, G., Fu, P. P., et al. (2002) · Journal of Environmental Science and Health Part C · doi:10.1081/gnc-120003928 · Cited by 13 · see citing works
Mutagenicity and chemical analysis of airborne particulate matter collected in Pisa.
Bronzetti, G. L., Cini, M., Paoli, M., et al. (1997) · PubMed · Cited by 12 · see citing works
Asthma, particulates, and diesel exhaust.
Chiaverini, L. C. (2002) · PubMed · Cited by 12 · see citing works
Air Quality Effects of Traffic in a Canyon-like Street (Falmouth, U.K.)
Parsons, B., & Salter, L. F. (2003) · Environmental Monitoring and Assessment · doi:10.1023/a:1021636807371 · Cited by 11 · see citing works
Study of the Toxicological Mechanism of Acidified Aerosols
Tong, Y., Ni, X., Zhang, Y., et al. (2002) · Biological Trace Element Research · doi:10.1385/bter:85:2:149 · Cited by 11 · see citing works
Bioassay of complex mixtures of indoor air pollutants.
Lewtas, J., Claxton, L. D., Mumford, J. L., et al. (1993) · PubMed · Cited by 10 · see citing works
Chemical characterization of the PM10 fraction of airborne particulate matter in the urban atmosphere.
Bagnoli, P., Carrozzino, S., Pisani, B., et al. (1997) · PubMed · Cited by 6 · see citing works
Seasonal Distributions of Acid Components in PM 2.5 Fraction of Airborne Particles in Zagreb Air
Čačković, M., Šega, K., Vađić, V., et al. (2001) · Bulletin of Environmental Contamination and Toxicology · doi:10.1007/s001280180 · Cited by 4 · see citing works
Seasonal Distributions of Acid Components in PM2.5 Fraction of Airborne Particles in Zagreb Air
Čačković, M., Šega, K., Vađić, V., et al. (2001) · Bulletin of Environmental Contamination and Toxicology · doi:10.1007/s00128-001-0180-1 · Cited by 4 · see citing works

Flagged first, then by citations

Sorted by citations

Formation, characteristics, and applications of environmentally persistent free radicals in biochars: A review
Ruan, X., Sun, Y., Du, W., Tang, Y., Liu, Q., Zhang, Z., Doherty, W., Frost, R. L., Qian, G., & Tsang, D. C. W. (2019) · Bioresource Technology · doi:10.1016/j.biortech.2019.02.105 · Cited by 402 · see citing works
Environmentally Persistent Free Radicals and Their Lifetimes in PM 2.5
Gehling, W., & Dellinger, B. (2013) · Environmental Science & Technology · doi:10.1021/es401767m · Cited by 278 · see citing works
A Systematic Review and Meta-Analysis of Multiple Airborne Pollutants and Autism Spectrum Disorder
Lam, J., Sutton, P., Kalkbrenner, A., Windham, G., Halladay, A., Koustas, E., Lawler, C., Davidson, L., Daniels, N., Newschaffer, C., et al. (2016) · PLOS ONE · doi:10.1371/journal.pone.0161851 · Cited by 247 · see citing works
Impact of airborne particulate matter on skin: a systematic review from epidemiology to in vitro studies
Dijkhoff, I. M., Drasler, B., Karakocak, B. B., Petri-Fink, A., Valacchi, G., Eeman, M., & Rothen-Rutishauser, B. (2020) · Particle and Fibre Toxicology · doi:10.1186/s12989-020-00366-y · Cited by 202 · see citing works
The Shared Pathoetiological Effects of Particulate Air Pollution and the Social Environment on Fetal-Placental Development
Erickson, A. C., & Arbour, L. (2014) · Journal of Environmental and Public Health · doi:10.1155/2014/901017 · Cited by 90 · see citing works
Oxidative damage induced in A549 cells by physically and chemically characterized air particulate matter (PM2.5) collected in Abidjan, Côte d'Ivoire
Kouassi, K. S., Billet, S., Garçon, G., Verdin, A., Diouf, A., Cazier, F., Djaman, J., Courcot, D., & Shirali, P. (2010) · Journal of Applied Toxicology · doi:10.1002/jat.1496 · Cited by 89 · see citing works
Using the 13 C/ 12 C carbon isotope ratio to characterise the emission sources of airborne particulate matter: a review of literature
Aguilera, J., & Whigham, L. D. (2018) · Isotopes in Environmental and Health Studies · doi:10.1080/10256016.2018.1531854 · Cited by 43 · see citing works
Diesel particle composition after exhaust after-treatment of an off-road diesel engine and modeling of deposition into the human lung
Oravisjärvi, K., Pietikäinen, M., Ruuskanen, J., Niemi, S., Laurén, M., Voutilainen, A., Keiski, R. L., & Rautio, A. (2014) · Journal of Aerosol Science · doi:10.1016/j.jaerosci.2013.11.008 · Cited by 32 · see citing works
Air Pollution and Skin Diseases
Han, H. S., Seok, J., & Park, K. Y. (2025) · Annals of Dermatology · doi:10.5021/ad.24.159 · Cited by 28 · see citing works
“PM 0.1 and PM 2.5 typically comprises hydrocarbons, metals, and secondary particles formed by atmospheric gases 2 .”
Influential
Prenatal and early-life air pollutant exposure and epigenetic aging acceleration
Lee, D.-W., Lim, Y.-H., Choi, Y.-J., Kim, S., Shin, C. H., Lee, Y. A., Kim, B.-N., Kim, J. I., & Hong, Y.-C. (2024) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2024.116823 · Cited by 14 · see citing works

ANALYSIS OF FINE PARTICULATE MATTER NEAR URBAN ROADWAYS
Balogh, M., Larson, T. V., & Mannering, F. (1993) · Transportation Research Record Journal of the Transportation Research Board · Cited by 4 · see citing works
TOTAL PARTICULATE MATTER, PM10, PM2.5 EMISSIONS FROM PALM OIL MILL BOILER
Syahirah, M. M., Rashid, M., & Ruwaida, J. N. (2016) · Jurnal Teknologi · doi:10.11113/jt.v78.9184 · Cited by 3 · see citing works
Study on the contribution ratios of particulate matter emissions in differential provinces concerning condensable particulate matter
Choi, D.-S., Kim, Y., Lee, I. H., et al. (2019) · Energy & Environment · doi:10.1177/0958305x19843555 · Cited by 18 · see citing works
A Study of the Characteristics of Primary Particulate Matter after the Combustion of Pulverized Coal of Different Particulate Diameters
Ding-kai, L. (2005) · Journal of Engineering for Thermal Energy and Power · Cited by 2 · see citing works
Differentiation of Particulate Matter Sources Based on the Chemical Composition of PM10 in Functional Urban Areas
Jandačka, D., & Ďurčanská, D. (2019) · Atmosphere · doi:10.3390/atmos10100583 · Cited by 35 · see citing works

Authors: de Kok, T. M. C. M., Driece, H. A. L., Hogervorst, J. G. F., & Briedé, J. J.
Affiliations: Maastricht University (NL)
ORCID: Hogervorst, Janneke G.F.
Briedé, Jacob J.
Venue: Mutation Research/Reviews in Mutation Research
Publisher: Elsevier BV
Published: 2006-11
Volume: 613
Issue: 2-3
Pages: 103-122
ISSN: 1383-5742 (ISSN-L)
DOI: 10.1016/j.mrrev.2006.07.001
OpenAlex: W2045621472
Cited by: 489
References: 107
Citations by year: 2026: 10 · 2025: 9 · 2024: 9 · 2023: 20 · 2022: 28 · 2021: 24 · 2020: 23 · 2019: 32 · 2018: 31 · 2017: 32 · 2016: 29 · 2015: 29 · 2014: 23 · 2013: 30 · 2012: 29
FWCI: 2.57
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Mutation Research/Reviews in Mutation Research (publishedVersion)
PubMed (publishedVersion)
Research Publications (Maastricht University) (publishedVersion)
Research Publications (Maastricht University) (submittedVersion)
Topics: Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Air Quality and Health Impacts
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Indoor Air Quality and Microbial Exposure
Keywords: particulate matter, traffic-related air pollution, ambient air pollution, toxicity prediction, cytotoxicity, mutagenicity, DNA damage, inflammatory cytokines, PM chemical composition, cardiovascular disease, respiratory diseases, lung cancer, acute respiratory infections
MeSH terms: Air Pollutants, Animals, Vehicle Emissions, Cytotoxins, DNA Damage, Humans, Mutagenicity Tests, Particle Size, Reactive Oxygen Species, In Vitro Techniques

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Toxicological assessment of ambient and traffic-related particulate matter: A review of recent studies

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks