The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Difference in the concentration of tryptophan metabolites between maternal and umbilical foetal blood
Abstract
Maternal and umbilical foetal blood at delivery were analysed for tryptophan metabolites by using fully automated high-performance liquid chromatography. The metabolites detected in 100 microliters of maternal plasma were kynurenine, serotonin, 5-hydroxyindoleacetic acid, indolelactic acid, indoleacetic acid and indolepropionic acid. These metabolites were present in various amounts in the protein-bound form. Except for indolepropionic acid, the concentrations of tryptophan metabolites were significantly higher in umbilical foetal plasma than in maternal plasma. In addition, 3-hydroxyanthranilic acid was present in umbilical foetal blood, but not in maternal blood. Furthermore, kynurenic acid was also detected in amniotic fluids.
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IPA can cross the blood-brain barrier and modulate astrocyte activation and neuroinflammation.
“Previous studies have demonstrated that IPA can cross the blood-brain barrier (30) and modulate astrocyte activation and neuroinflammation; it can also inhibit neuronal death induced by endoplasmic reticulum stress (31).”
From Sepsis-Induced Gut Dysbiosis Mediates the Susceptibility to Sepsis-Associated Encephalopathy in Mice (2022) · cites this paper as [30]
IPA has a protective effect against neuronal inflammation.
“These studies indicate the protective effect of IPA against neuronal inflammation, which prompted us to select IPA from the metabolites enriched in SER feces as a possible protective substance against SAE.”
From Sepsis-Induced Gut Dysbiosis Mediates the Susceptibility to Sepsis-Associated Encephalopathy in Mice (2022) · cites this paper as [30]
Citations
Cites
Diagnosis of the respiratory distress syndrome by amniocentesis
Gluck, L., Kulovich, M. V., Borer, R. C., Brenner, P. H., Anderson, G. G., & Spellacy, W. N. (1971) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(71)90342-5 · Cited by 904
Yamazaki, F., Kuroiwa, T., Takikawa, O., et al. (1985) · Biochemical Journal · doi:10.1042/bj2300635 · Cited by 244
Yoshida, H., Morita, I., Tamai, G., et al. (1984) · Chromatographia · doi:10.1007/bf02687789 · Cited by 94
Self-citationHeyes, M., & Quearry, B. (1990) · Journal of Chromatography A · doi:10.1016/s0378-4347(00)82308-7 · Cited by 52
Morita, I., Kawamoto, M., Hattori, M., et al. (1990) · Journal of Chromatography B Biomedical Sciences and Applications · doi:10.1016/s0378-4347(00)82520-7 · Cited by 43
Self-citationFamilial hypertryptophanemia, tryptophanuria and indoleketonuria
Snedden, W., Mellor, C. S., & Martin, J. R. (1983) · Clinica Chimica Acta · doi:10.1016/0009-8981(83)90094-3 · Cited by 34
Morita, I., Masujima, T., Yoshida, H., et al. (1985) · Analytical Biochemistry · doi:10.1016/0003-2697(85)90188-5 · Cited by 34
Self-citationChin, J. R. L. (1990) · Journal of Chromatography B Biomedical Sciences and Applications · doi:10.1016/s0378-4347(00)82367-1 · Cited by 33
Free amino acids in human fetal plasma
Kamoun, P., Droin, V., Forestier, F., et al. (1985) · Clinica Chimica Acta · doi:10.1016/0009-8981(85)90248-7 · Cited by 23
High-performance liquid chromatographic assay of human lymphocyte kynureninase activity levels
Ubbink, J., Vermaak, W. J. H., & Bissbort, S. (1991) · Journal of Chromatography B Biomedical Sciences and Applications · doi:10.1016/0378-4347(91)80253-9 · Cited by 19
Brumfield, C. G., Cloud, G. A., Davis, R. O., et al. (1990) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(90)91093-r · Cited by 18
Screening of amniotic fluid metabolites by gas chromatography-mass spectrometry
Antoshechkin, A. G., Golovkin, A. B., Maximova, L. A., et al. (1989) · Journal of Chromatography B Biomedical Sciences and Applications · doi:10.1016/s0378-4347(00)82913-8 · Cited by 11
Pattern of human blood spermidine and spermine in prematurity
Casti, A., Bacciottini, F., Orlandini, G., et al. (1985) · Clinica Chimica Acta · doi:10.1016/0009-8981(85)90203-7 · Cited by 8
Determination of nanogram amounts of catecholamine metabolites in amniotic fluid
Dziedzic, L. M., Dziedzic, S. W., Cerqueira, S., et al. (1982) · Clinica Chimica Acta · doi:10.1016/0009-8981(82)90259-5 · Cited by 4
Concentrations of polyamines in umbilical blood.
Hiramatsu, Y., Eguchi, K., & Sekiba, K. (1985) · PubMed · doi:10.18926/amo/31496 · Cited by 1
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Research works printed but not linked: 3
- Yoshida, 1983, Jpn. J. Clin. Chem., 12, 312
- Yoshida, 1978, Hiroshima J. Med. Sci., 27, 85
- Hiramatsu, 1985, Acta Med. Okayama, 39, 265
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Sepsis-Induced Gut Dysbiosis Mediates the Susceptibility to Sepsis-Associated Encephalopathy in Mice
Fang, H., Wang, Y., Deng, J., Zhang, H., Wu, Q., He, L., Xu, J., Shao, X., Ouyang, X., He, Z., et al. (2022) · mSystems · doi:10.1128/msystems.01399-21 · Cited by 87
“Previous studies have demonstrated that IPA can cross the blood-brain barrier (30) and modulate astrocyte activation and neuroinflammation; it can also inhibit neuronal death induced by endoplasmic reticulum stress (31).”
Background
Metadata
- Authors
- Morita, I., Kawamoto, M., & Yoshida, H.
- Affiliations
- Hiroshima University (JP)
- Venue
- Journal of Chromatography B: Biomedical Sciences and Applications
- Publisher
- Elsevier BV
- Published
- 1992-05
- Volume
- 576
- Issue
- 2
- Pages
- 334-339
- ISSN
- 0378-4347 (ISSN-L)
- OpenAlex
- W2011083680
- Cited by
- 47
- References
- 15
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 4 · 2020: 2 · 2019: 1 · 2018: 3 · 2017: 2 · 2016: 3 · 2015: 3 · 2014: 3 · 2013: 1 · 2012: 1
- FWCI
- 0.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Chromatography B Biomedical Sciences and Applications (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolomics and Mass Spectrometry Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
- Keywords
- tryptophan metabolites, maternal plasma, umbilical cord blood, kynurenine, serotonin, 5-hydroxyindoleacetic acid, indolepropionic acid, 3-hydroxyanthranilic acid, kynurenic acid, amniotic fluid
- MeSH terms
- Amino Acids, Amniotic Fluid, Chromatography, High Pressure Liquid, Female, Fetal Blood, Fetus, Humans, Indicators and Reagents, Infant, Newborn, Pregnancy, Spectrometry, Fluorescence, Spectrophotometry, Ultraviolet, Tryptophan
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