CoChat
Sign Up
Cited by 54Menopause: Health Impacts and TreatmentsEstrogen and related hormone effectsLipoproteins and Cardiovascular Health

Long-term effects of transdermal and oral estrogens on serum lipids and lipoproteins in postmenopausal women.

Adami, Silvano, Rossini, Maurizio, Zamberlan, Nicoletta, Bertoldo, Francesco, Dorizzi, Romolo, Lo Cascio, Vincenzo·1993·Maturitas
DOI 10.1016/0378-5122(93)90046-k
Open this paper in CoChat — free account

Abstract

The transdermal and oral administration of estrogens for one year were compared with respect to the effects on lipid metabolism. Eighty-one postmenopausal women (1.5-3 years after menopause) were randomly divided into three groups. The first two groups received sequential estrogen treatment with either transdermal estradiol (Estraderm TTS, Ciba Geigy; 50 micrograms/day; 24 women) or 0.625 mg/day conjugated estrogens (Premarin, Wyeth; 20 subjects), respectively. In both groups medroxyprogesterone (10 mg/day per os) was added for 12 days of each cycle. Thirty-five subjects served as control group without therapy. No significant changes in the lipid profile was observed in control subjects after 1 year of follow-up. Serum triglycerides decreased significantly (-10.9 +/- 26% S.D.; P < 0.05) in transdermal treated women, whereas it slightly rose in oral estrogen group. Comparable significant decreases in total and low density lipoprotein (LDL) cholesterol (mean range -6.5/-18.0%) were observed in women on estrogen replacement therapy. High density lipoprotein (HDL) cholesterol significantly diminished in transdermal estradiol group, but it rose slightly in the oral estrogen group. Thus the fraction of HDL cholesterol over LDL cholesterol did not change in the transdermal group whereas it significantly rose in subjects treated with oral estrogens. It remains to be established to what extent these differences on lipid metabolism are relevant for the prevention of cardiovascular diseases.

Integrity signals

Registry

Crossref · 10.1016/0378-5122(93)90046-k

Cites

32 of 32 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Oral estrogen in the form of estrogen replacement therapy or oral contraceptives has a triglyceride-increasing effect due to increased hepatic VLDL production; this effect does not occur with transdermal estrogen due to lesser exposure to the liver.

    “Oral estrogen in the form of estrogen replacement therapy or oral contraceptives has a triglyceride-increasing effect due to increased hepatic VLDL production.This effect does not occur with transdermal estrogen due to its lesser exposure to the liver (87, 88).”

    From Evaluation and Treatment of Hypertriglyceridemia: An Endocrine Society Clinical Practice Guideline (2012) · cites this paper as [88]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Adami, S., Rossini, M., Zamberlan, N., Bertoldo, F., Dorizzi, R., & Lo Cascio, V.
Affiliations
University of Verona (IT)
Corresponding author
Adami, Silvano
ORCID
Venue
Maturitas
Publisher
Elsevier BV
Published
1993-11
Volume
17
Issue
3
Pages
191-196
ISSN
0378-5122 (ISSN-L)
DOI
10.1016/0378-5122(93)90046-k
OpenAlex
W2072524967
Cited by
54
References
32
Citations by year
2026: 1 · 2022: 1 · 2019: 1 · 2018: 1 · 2016: 1 · 2014: 3 · 2013: 2 · 2012: 1
FWCI
2.39
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Maturitas (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
  • Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
Keywords
transdermal estradiol, estrogen replacement therapy, postmenopausal women, serum lipids, lipoproteins, triglycerides, LDL cholesterol, HDL cholesterol, medroxyprogesterone, lipid metabolism, cardiovascular disease prevention
MeSH terms
Administration, Cutaneous, Administration, Oral, Cholesterol, Estradiol, Estrogens, Conjugated (USP), Female, Humans, Lipids, Lipoproteins, Cholesterol, HDL, Cholesterol, LDL, Middle Aged, Triglycerides, Estrogen Replacement Therapy, Postmenopause

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review