CoChat
Sign Up
Cited by 157Hearing, Cochlea, Tinnitus, GeneticsChemotherapy-induced organ toxicity mitigationVestibular and auditory disorders

The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.

Variable efficacy of radical scavengers and iron chelators to attenuate gentamicin ototoxicity in guinea pig in vivo

Song, Ben-Bo, Schacht, Jochen·1996·Hearing Research
DOI 10.1016/0378-5955(96)00003-2
Open this paper in CoChat — free account

Abstract

Recent studies from our laboratory have suggested that the ototoxic side effects of gentamicin are caused by a metabolized or 'activated' from the drug. Furthermore, we have postulated that the activation proceeds via the formation of an iron-gentamicin complex and that this complex produces free radicals. The present study assessed the protection effects of free radical scavengers and iron chelators on gentamicin-induced ototoxicity in guinea pigs in vivo. Gentamicin (120 mg/kg per day for 19 days) caused progressive threshold shifts reaching 50-65 dB at 18 kHz. Co-therapy with different radical scavengers yielded results ranging from no protection (with allopurinol, dimethyl sulfoxide, benzoate, lazaroid U74389G) to a moderate attenuation of hearing loss (with mannitol, 4-methylthiobenzoate, WR-2721). This finding agrees well with previous reports of inconsistent effects of scavengers on aminoglycoside-induced ototoxicity although it should be cautioned that only a single dose and route of application was tested. Two iron chelators, deferoxamine and 2,3-dihydroxybenzoate, significantly reduced the gentamicin-induced threshold shifts to about 10 dB or less. Iron chelators markedly decreased total serum iron levels while gentamicin treatment alone had no influence. There were no differences in serum gentamicin levels among all treated groups. This study confirms that iron plays a critical role in gentamicin ototoxicity and suggests that iron chelators, which are well-established drugs in clinical therapy, may be promising therapeutic agents to reduce aminoglycoside ototoxicity.

Overview

Integrity signals

Registry

Crossref · 10.1016/0378-5955(96)00003-2

Cites

41 of 41 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Research works printed but not linked: 2

  1. Evenson, 1995, MTBA as a protective agent for cisplatin ototoxicity, Abstr. Assoc. Res. Otolaryngol., 18, 81
  2. Wang, 1996, The iron embrace: exposing the secret activities of gentamicin, Abst. Assoc. Res. Otolaryngol., 19, 29

Cited by

Sorted by citations

See all 157

Related

See all

Metadata

Authors
Song, B.-B., & Schacht, J.
Affiliations
University of Michigan (US)
Corresponding author
Schacht, Jochen
ORCID
Schacht, Jochen
Venue
Hearing Research
Publisher
Elsevier BV
Published
1996-05
Volume
94
Issue
1-2
Pages
87-93
ISSN
0378-5955 (ISSN-L)
DOI
10.1016/0378-5955(96)00003-2
OpenAlex
W2047770131
Cited by
157
References
41
Citations by year
2026: 1 · 2024: 6 · 2023: 1 · 2020: 5 · 2019: 3 · 2018: 1 · 2017: 4 · 2016: 5 · 2015: 3 · 2014: 5 · 2013: 2 · 2012: 6
FWCI
7.97
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Hearing Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health
  • National Institute on Deafness and Other Communication Disorders (DC-00124)
Topics
  • Life Sciences › Neuroscience › Sensory Systems › Hearing, Cochlea, Tinnitus, Genetics
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Chemotherapy-induced organ toxicity mitigation
  • Life Sciences › Neuroscience › Neurology › Vestibular and auditory disorders
Keywords
gentamicin ototoxicity, aminoglycoside ototoxicity, radical scavengers, iron chelators, threshold shift, deferoxamine, 2,3-dihydroxybenzoate, serum iron, guinea pig
MeSH terms
Administration, Oral, Allopurinol, Analysis of Variance, Animals, Anti-Bacterial Agents, Antimetabolites, Antioxidants, Auditory Threshold, Benzoates, Deferoxamine, Dimethyl Sulfoxide, Amifostine, Gentamicins, Guinea Pigs, Injections, Intraperitoneal, Injections, Subcutaneous, Iron, Iron Chelating Agents, Male, Mannitol, Pregnatrienes, Free Radical Scavengers, Hydroxybenzoates

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review