Iron promoters of the Fenton reaction and lipid peroxidation can be released from haemoglobin by peroxides
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Hydroxyl radical Lipid peroxidation Transferrin iron binding Heme‐protein iron release Hemoglobin Fenton catalyst Desferrioxamine Bleomycin‐detectable iron
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The source of this iron is most likely plasma-released Hb; the reaction of plasma Hb with peroxides can cause the release of free iron.
“The source of this iron is most likely plasma-released Hb; whereas Hb or heme are not catalysts for the Fenton reaction, the reaction of plasma Hb with peroxides can cause the release of free iron (389, 759).”
From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [389]
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- Authors
- Gutteridge, J. M. C.
- Affiliations
- National Institute for Biological Standards and Control (GB)
- Corresponding author
- Gutteridge, John M.C.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1986-06-09
- Volume
- 201
- Issue
- 2
- Pages
- 291-295
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2061885883
- Cited by
- 629
- References
- 19
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 8 · 2023: 9 · 2022: 12 · 2021: 9 · 2020: 9 · 2019: 15 · 2018: 11 · 2017: 14 · 2016: 10 · 2015: 16 · 2014: 11 · 2013: 16 · 2012: 13
- FWCI
- 27.88
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- FEBS Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Chemistry › Inorganic Chemistry › Metal-Catalyzed Oxygenation Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hemoglobin structure and function
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Keywords
- hemoglobin, iron release, Fenton reaction, lipid peroxidation, hydrogen peroxide, organic hydroperoxides, apotransferrin, bleomycin, deferoxamine, hydroxyl radicals, DNA degradation, deoxyribose degradation
- MeSH terms
- Apoproteins, Bleomycin, Catalase, Ceruloplasmin, Deferoxamine, Deoxyribose, Hemoglobins, Humans, Hydrogen Peroxide, Hydroxides, Iron, Lipid Peroxides, Peroxides, Transferrin, Hydroxyl Radical
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