Cited by 629Metal-Catalyzed Oxygenation MechanismsHemoglobin structure and functionAntioxidant Activity and Oxidative Stress

Iron promoters of the Fenton reaction and lipid peroxidation can be released from haemoglobin by peroxides

Open access
Gutteridge, John M.C.·1986·FEBS Letters

Abstract

Hydroxyl radical Lipid peroxidation Transferrin iron binding Heme‐protein iron release Hemoglobin Fenton catalyst Desferrioxamine Bleomycin‐detectable iron

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/0014-5793(86)80626-3

Cites

19 of 19 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • The source of this iron is most likely plasma-released Hb; the reaction of plasma Hb with peroxides can cause the release of free iron.

    “The source of this iron is most likely plasma-released Hb; whereas Hb or heme are not catalysts for the Fenton reaction, the reaction of plasma Hb with peroxides can cause the release of free iron (389, 759).”

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 2

  1. Carter, P. (1971) Anal. Biochem. 40, 450-458. 18733468, 1986, 2, Downloaded from https://febs.onlinelibrary.wiley.com/doi/10.1016/0014-5793(86)80626-3, Wiley Online Library on [29/04/2025]. See the Terms and Conditions (https://onlinelibrary.wiley.com/terms-and-conditions) on Wiley Online Library for rules of use; OA articles are governed by the applicable Creative Commons License
  2. Peters, S.W., Jones, B.M., Jacobs, A. and Wagstaff, M. (1985) in: Proteins of Iron Storage and Metabolism (Spik, G. et al. eds) pp.32I-324, Elsevier, Amsterdam, New York.

Cited by

Sorted by citations

Authors
Gutteridge, J. M. C.
Affiliations
National Institute for Biological Standards and Control (GB)
Corresponding author
Gutteridge, John M.C.
Venue
FEBS Letters
Publisher
Wiley
Published
1986-06-09
Volume
201
Issue
2
Pages
291-295
ISSN
  • 0014-5793 (ISSN-L)
  • 1873-3468
OpenAlex
W2061885883
Cited by
629
References
19
Citations by year
2026: 1 · 2025: 5 · 2024: 8 · 2023: 9 · 2022: 12 · 2021: 9 · 2020: 9 · 2019: 15 · 2018: 11 · 2017: 14 · 2016: 10 · 2015: 16 · 2014: 11 · 2013: 16 · 2012: 13
FWCI
27.88
Type
journal article
Language
en
Open access
Locations
  • FEBS Letters (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Physical Sciences › Chemistry › Inorganic Chemistry › Metal-Catalyzed Oxygenation Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hemoglobin structure and function
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
Keywords
hemoglobin, iron release, Fenton reaction, lipid peroxidation, hydrogen peroxide, organic hydroperoxides, apotransferrin, bleomycin, deferoxamine, hydroxyl radicals, DNA degradation, deoxyribose degradation
MeSH terms
Apoproteins, Bleomycin, Catalase, Ceruloplasmin, Deferoxamine, Deoxyribose, Hemoglobins, Humans, Hydrogen Peroxide, Hydroxides, Iron, Lipid Peroxides, Peroxides, Transferrin, Hydroxyl Radical

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review