The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Effect of Bacopa monniera Linn. (Brāhmi) extract on avoidance responses in rat
Abstract
Brahmi (Bacopa monniera Linn.) is a reputed nerve tonic in Ayurvedic literature. Hence its effects on the learning performance of rats have been studied in different conditioning schedules by administering an aqueous suspension of an alcoholic extract (40 mg/kg, p.o.) for three or more days. The first schedule induced a labile behaviour using a shock-motivated brightness-discrimination reaction. The brahmi-treated group showed better acquisition, improved retention and delayed extinction (p is less than 0.01-0.05). Similarly, in an active conditioned flight reaction, the drug-treated animals showed a shorter reaction time than the controls (p less than 0.01). Also in the continuous avoidance response the drug-treated group performed better than the controls (p less than 0.01-0.05). Our findings are in conformity with the Ayurvedic claims and indicate that Bacopa monniera can improve the performance of rats in various learning situations.
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“Animal studies have shown that Bacopa facilitates learning and memory, [12][13][14] while the following five randomized, double-blind, placebo-controlled trials provide evidence for its efficacy in improving cognitive performance in humans.”
From Does Bacopa monnieri Improve Memory Performance in Older Persons? Results of a Randomized, Placebo-Controlled, Double-Blind Trial (2010) · cites this paper as [14]
In the citing paper
“and improve memory in the form of pain avoidance in rats.11”
From Bacopa monnieri (L.) wettst. Extract protects against glutamate toxicity and increases the longevity of Caenorhabditis elegans (2020) · cites this paper as [11]
Citations
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Metadata
- Authors
- Singh, H. K., & Dhawan, B. N.
- Affiliations
- Central Drug Research Institute (IN)
- ORCID
- Singh, H.K.
- Venue
- Journal of Ethnopharmacology
- Publisher
- Elsevier BV
- Published
- 1982-03
- Volume
- 5
- Issue
- 2
- Pages
- 205-214
- ISSN
- 0378-8741 (ISSN-L)
- OpenAlex
- W2080765501
- Cited by
- 162
- References
- 8
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 3 · 2023: 6 · 2022: 2 · 2021: 6 · 2020: 8 · 2019: 3 · 2018: 4 · 2017: 3 · 2016: 6 · 2015: 2 · 2014: 6 · 2013: 8 · 2012: 8
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Ethnopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Health Sciences › Medicine › Complementary and alternative medicine › Phytochemicals and Medicinal Plants
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- Bacopa monnieri, avoidance learning, memory retention, extinction, brightness discrimination, learning performance, Ayurveda, alcoholic plant extract, rats
- MeSH terms
- Animals, Avoidance Learning, Behavior, Animal, India, Male, Plant Extracts, Reaction Time, Rats
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