Cited by 162Medicinal Plants and NeuroprotectionPhytochemicals and Medicinal PlantsMemory and Neural Mechanisms

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Effect of Bacopa monniera Linn. (Brāhmi) extract on avoidance responses in rat

Singh, H.K., Dhawan, B.N.·1982·Journal of Ethnopharmacology

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Abstract

Brahmi (Bacopa monniera Linn.) is a reputed nerve tonic in Ayurvedic literature. Hence its effects on the learning performance of rats have been studied in different conditioning schedules by administering an aqueous suspension of an alcoholic extract (40 mg/kg, p.o.) for three or more days. The first schedule induced a labile behaviour using a shock-motivated brightness-discrimination reaction. The brahmi-treated group showed better acquisition, improved retention and delayed extinction (p is less than 0.01-0.05). Similarly, in an active conditioned flight reaction, the drug-treated animals showed a shorter reaction time than the controls (p less than 0.01). Also in the continuous avoidance response the drug-treated group performed better than the controls (p less than 0.01-0.05). Our findings are in conformity with the Ayurvedic claims and indicate that Bacopa monniera can improve the performance of rats in various learning situations.

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Authors: Singh, H. K., & Dhawan, B. N.
Affiliations: Central Drug Research Institute (IN)
ORCID: Singh, H.K.
Venue: Journal of Ethnopharmacology
Publisher: Elsevier BV
Published: 1982-03
Volume: 5
Issue: 2
Pages: 205-214
ISSN: 0378-8741 (ISSN-L)
DOI: 10.1016/0378-8741(82)90044-7
OpenAlex: W2080765501
Cited by: 162
References: 8
Citations by year: 2026: 2 · 2025: 1 · 2024: 3 · 2023: 6 · 2022: 2 · 2021: 6 · 2020: 8 · 2019: 3 · 2018: 4 · 2017: 3 · 2016: 6 · 2015: 2 · 2014: 6 · 2013: 8 · 2012: 8
FWCI: 0.00
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Ethnopharmacology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
Health Sciences › Medicine › Complementary and alternative medicine › Phytochemicals and Medicinal Plants
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: Bacopa monnieri, avoidance learning, memory retention, extinction, brightness discrimination, learning performance, Ayurveda, alcoholic plant extract, rats
MeSH terms: Animals, Avoidance Learning, Behavior, Animal, India, Male, Plant Extracts, Reaction Time, Rats

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Effect of Bacopa monniera Linn. (Brāhmi) extract on avoidance responses in rat

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