Proarrhythmia, cardiac arrest and death in young patients receiving encainide and flecainide
Open accessAbstract
The potential for proarrhythmic responses to the class IC sodium channel-blocking drugs encainide and flecainide has not been well described in young patients. Therefore, data were retrospectively collected from 36 institutions regarding 579 young patients who were administered encainide or flecainide for treatment of supraventricular tachycardias (encainide 86 patients, flecainide 369 patients) or ventricular arrhythmias (encainide 21 patients, flecainide 103 patients) to assess the frequency of proarrhythmia, cardiac arrest and death during therapy (adverse events). The two drugs were similar in regard to efficacy (flecainide 71.4%, encainide 59.8%) and rate of proarrhythmic responses (flecainide 7.4%; encainide 7.5%). However, patients receiving encainide more frequently experienced cardiac arrest (encainide 7.5% vs. flecainide 2.3%, p less than 0.05) or died during treatment (encainide 7.5% vs. flecainide 2.1%, p less than 0.05). Detailed data were provided for 44 patients experiencing one or more adverse events. Patient age, previous drug trials, concomitant therapy and days of inpatient monitoring were similar for patients receiving encainide or flecainide. However, echocardiographic left ventricular shortening before treatment was lower among patients receiving encainide (0.23 +/- 0.09) than among those receiving flecainide (0.34 +/- 0.06, p less than 0.05). Plasma drug concentrations were rarely elevated. Cardiac arrest (12 patients) and deaths (13 patients) occurred predominantly among patients with underlying heart disease, particularly among patients receiving flecainide for supraventricular tachycardia (8.3% vs. 0.3%, p less than 0.001). Fifteen patients with an ostensibly normal heart and normal ventricular function experienced proarrhythmia during treatment for supraventricular tachycardia, but only 3 of the 15 had a cardiac arrest or died. The relatively high incidence of adverse events should be considered when contemplating treatment with encainide or flecainide, particularly among patients with underlying heart disease.
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Class Ic drugs such as encainide and flecainide are proarrhythmic.
“Class Ic drugs such as encainide and flecainide are also proarrhythmic and should not be used in ACHD patients.370”
From European Heart Rhythm Association (EHRA) consensus document on the management of supraventricular arrhythmias, endorsed by Heart Rhythm Society (HRS), Asia-Pacific Heart Rhythm Society (APHRS), and Sociedad Latinoamericana de Estimulacion Cardiaca y Electrofisiologia (SOLAECE) (2017) · cites this paper as [370]
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- Authors
- Fish, F. A., Gillette, P. C., & Benson, D. W.
- Affiliations
- Northwestern University (US)
- Medical University of South Carolina (US)
- Corresponding author
- Fish, Frank A
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 1991-08
- Volume
- 18
- Issue
- 2
- Pages
- 356-365
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W2084942160
- Cited by
- 193
- References
- 37
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 2 · 2023: 6 · 2022: 3 · 2021: 9 · 2020: 4 · 2019: 6 · 2018: 4 · 2017: 14 · 2016: 3 · 2015: 8 · 2014: 13 · 2013: 8 · 2012: 7
- FWCI
- 6.21
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Arrhythmias and Treatments
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pharmacovigilance and Adverse Drug Reactions
- Keywords
- encainide, flecainide, class Ic antiarrhythmic drugs, drug-induced arrhythmia, cardiac arrest, drug-induced death, young patients, supraventricular tachycardia, ventricular arrhythmias, underlying heart disease, left ventricular shortening, adverse drug reactions, sodium channel blockers, plasma drug concentration, inpatient monitoring, drug safety and efficacy
- MeSH terms
- Anilides, Anti-Arrhythmia Agents, Arrhythmias, Cardiac, Child, Death, Sudden, Flecainide, Heart Arrest, Humans, Retrospective Studies, Risk Factors, Tachycardia, Tachycardia, Supraventricular, Incidence, Encainide
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