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Densities of dopamine D2 receptors are reduced in CNS regions of alcohol-preferring P rats
Abstract
The densities of dopamine D2 recognition sites labelled with [3H]sulpiride were determined in the caudate-putamen, nucleus accumbens (medial and lateral portions), olfactory tubercle, substantia nigra (pars reticulata and pars compacta), and ventral tegmental area (VTA) of alcohol-naive, selectively bred P (N = 7) and NP (N = 7) rats using quantitative autoradiography. The binding of [3H]sulpiride was 20-25% lower (P < 0.05) in the caudate-putamen, medial and lateral nucleus accumbens, and VTA of the P compared with the NP rats. No significant differences were observed between the P and NP rats in the olfactory tubercle or substantia nigra. [3H]Sulpiride binding, using standard membrane preparations, established with Scatchard analysis that the difference in the densities of D2 recognition sites in the caudate-putamen between the P and NP rats was due to lower Bmax values for the P line. The results indicate that the number of dopamine D2 receptor sites is lower in several central nervous system regions of the P rats compared to NP rats.
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“Strikingly, animals with low D2 receptor levels in the striatum prior to drug or alcohol exposure subsequently display greater cocaine or alcohol self-administration (Czoty et al., 2004; Dalley et al., 2007; McBride et al., 1993; Morgan et al., 2002; Nader et al., 2006; Stefanini et al., 1992).”
From Imaging addiction: D2 receptors and dopamine signaling in the striatum as biomarkers for impulsivity (2014) · cites this paper as McBride et al., 1993
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Metadata
- Authors
- McBride, W. J., Chernet, E., Dyr, W., Lumeng, L., & Li, T.-K.
- Affiliations
- Richard L. Roudebush VA Medical Center (US)
- Corresponding author
- McBride, W.J.
- ORCID
- Venue
- Alcohol
- Publisher
- Elsevier BV
- Published
- 1993-09
- Volume
- 10
- Issue
- 5
- Pages
- 387-390
- ISSN
- 0741-8329 (ISSN-L)
- OpenAlex
- W2062725718
- Cited by
- 160
- References
- 30
- Citations by year
- 2026: 2 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 4 · 2020: 4 · 2019: 3 · 2018: 3 · 2017: 3 · 2016: 5 · 2015: 6 · 2014: 5 · 2013: 6 · 2012: 6
- FWCI
- 1.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Alcohol (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5p01aa008553-03)
- National Institute on Alcohol Abuse and Alcoholism (AA-07611, AA-07462, AA 08553, T32AA007462)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Keywords
- dopamine D2 receptor, receptor density, alcohol-preferring rats, caudate-putamen, nucleus accumbens, olfactory tubercle, substantia nigra, ventral tegmental area, alcohol preference
- MeSH terms
- Alcohol Drinking, Animals, Brain, Male, Nucleus Accumbens, Olfactory Pathways, Rats, Inbred Strains, Substantia Nigra, Sulpiride, Tegmentum Mesencephali, Rats, Wistar, Receptors, Dopamine D2, Rats
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