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Densities of dopamine D2 receptors are reduced in CNS regions of alcohol-preferring P rats

McBride, W.J., Chernet, E., Dyr, W., Lumeng, L., Li, T.-K.·1993·Alcohol

DOI 10.1016/0741-8329(93)90025-j

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Abstract

The densities of dopamine D2 recognition sites labelled with [3H]sulpiride were determined in the caudate-putamen, nucleus accumbens (medial and lateral portions), olfactory tubercle, substantia nigra (pars reticulata and pars compacta), and ventral tegmental area (VTA) of alcohol-naive, selectively bred P (N = 7) and NP (N = 7) rats using quantitative autoradiography. The binding of [3H]sulpiride was 20-25% lower (P < 0.05) in the caudate-putamen, medial and lateral nucleus accumbens, and VTA of the P compared with the NP rats. No significant differences were observed between the P and NP rats in the olfactory tubercle or substantia nigra. [3H]Sulpiride binding, using standard membrane preparations, established with Scatchard analysis that the difference in the densities of D2 recognition sites in the caudate-putamen between the P and NP rats was due to lower Bmax values for the P line. The results indicate that the number of dopamine D2 receptor sites is lower in several central nervous system regions of the P rats compared to NP rats.

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Authors: McBride, W. J., Chernet, E., Dyr, W., Lumeng, L., & Li, T.-K.
Affiliations: Richard L. Roudebush VA Medical Center (US)
Corresponding author: McBride, W.J.
ORCID: McBride, W.J.
Dyr, W.
Venue: Alcohol
Publisher: Elsevier BV
Published: 1993-09
Volume: 10
Issue: 5
Pages: 387-390
ISSN: 0741-8329 (ISSN-L)
DOI: 10.1016/0741-8329(93)90025-j
OpenAlex: W2062725718
Cited by: 160
References: 30
Citations by year: 2026: 2 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 4 · 2020: 4 · 2019: 3 · 2018: 3 · 2017: 3 · 2016: 5 · 2015: 6 · 2014: 5 · 2013: 6 · 2012: 6
FWCI: 1.45
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Alcohol (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5p01aa008553-03)
National Institute on Alcohol Abuse and Alcoholism (AA-07611, AA-07462, AA 08553, T32AA007462)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Keywords: dopamine D2 receptor, receptor density, alcohol-preferring rats, caudate-putamen, nucleus accumbens, olfactory tubercle, substantia nigra, ventral tegmental area, alcohol preference
MeSH terms: Alcohol Drinking, Animals, Brain, Male, Nucleus Accumbens, Olfactory Pathways, Rats, Inbred Strains, Substantia Nigra, Sulpiride, Tegmentum Mesencephali, Rats, Wistar, Receptors, Dopamine D2, Rats

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Densities of dopamine D2 receptors are reduced in CNS regions of alcohol-preferring P rats

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