Pharmacological control of ciliary activity in the young sea urchin larva. Effects of monoaminergic agents
Abstract
Ciliary activity is affected by serotonin, dopamine and various alpha- and beta-adrenergic agonists reacting with specific receptors. The effects of various monoamine precursors applied at hatching or later on suggest that the initiation of ciliary activity and its control during early gastrulation reflects a temporary formation of monoamines. Application of monoamines brings about stimulation throughout gastrulation with some exceptions which may reflect side effects or some mechanism of feedback inhibition. Strong stimulation is often followed by conspicuous, transient decrease in ciliary activity around the mid-gastrula stage presumably reflecting feedback inhibition and compensatory mechanisms alleviating this.
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Serotonin seems to play a general role in the upregulation of ciliary beat frequency in mollusc, echinoderm and annelid larvae.
“Serotonin seems to play a general role in the upregulation of ciliary beat frequency (in mollusc [48], echinoderm [49,50] and annelid (G. Jékely unpublished) larvae), and the control of cilia by a sensory-motor serotonergic system may trace back to the common ancestor of protostomes and deuterostomes.”
From Origin and early evolution of neural circuits for the control of ciliary locomotion (2011) · cites this paper as [49]
Cites
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- Authors
- Soliman, S.
- Affiliations
- Stockholm University (SE)
- Corresponding author
- Soliman, Sherif
- ORCID
- Soliman, Sherif
- Venue
- Comparative Biochemistry and Physiology Part C Comparative Pharmacology
- Publisher
- Elsevier BV
- Published
- 1983-01
- Volume
- 76
- Issue
- 1
- Pages
- 181-191
- ISSN
- 0306-4492 (ISSN-L)
- OpenAlex
- W2050555963
- Cited by
- 24
- References
- 10
- Citations by year
- 2024: 1 · 2023: 2 · 2022: 1 · 2021: 2 · 2019: 2 · 2018: 1 · 2013: 1 · 2012: 1
- FWCI
- 0.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Comparative Biochemistry and Physiology Part C Comparative Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Physical Sciences › Earth and Planetary Sciences › Paleontology › Marine Invertebrate Physiology and Ecology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Kidney Cyst Diseases
- Keywords
- ciliary activity, sea urchin larvae, monoamines, serotonin, dopamine, sympathomimetic drugs, monoamine precursors, gastrulation, product inhibition, larval development
- MeSH terms
- Animals, Catecholamines, Cilia, Glycine, Larva, Sea Urchins, Serotonin, Tyramine
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