The diffusion-controlled reaction of semioxidized tryptophan with the superoxide radical anion
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From pulse radiolysis measurements in oxygenated aqueous solution, the semioxidized tryptophan radical (Trp.- formed by the one-electron oxidation of Trp by Br2- radical--has been shown to oxidize the superoxide radical anion with a rate constant of k = 2 x 10(9) M-1 s-1. Proof of this reaction is found in addition of superoxide dismutase (SOD) to the system, which totally eliminates the contribution of the Trp. + O2- mechanism to Trp. decay. Little, if any, reaction of molecular oxygen with Trp. may be observed on the time scale of the pulse radiolysis experiment.
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Trp• reacts very rapidly with O2•− with second-order rate constants k in the range 0.7-2.2 × 10^9 M−1 s−1, mainly giving hydroperoxides in almost quantitative yields.
“Trp• reacts very rapidly with O2•− with second order rate constants, k, in the range 0.7–2.2 × 109 M−1 s−1, the main initial products being hydroperoxides, in almost quantitative yields [145,146,147,148,149,150,151], Figure 56.”
From Superoxide Anion Chemistry—Its Role at the Core of the Innate Immunity (2023) · cites this paper as [149]
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Cites
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Superoxide Anion Chemistry—Its Role at the Core of the Innate Immunity
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Superoxide-dependent Oxidation of Melatonin by Myeloperoxidase
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- Authors
- Santus, R., Patterson, L. K., & Bazin, M.
- Affiliations
- University of Notre Dame (US)
- Inserm (FR)
- ORCID
- Patterson, Larry K.
- Venue
- Free Radical Biology and Medicine
- Publisher
- Elsevier BV
- Published
- 1995-12
- Volume
- 19
- Issue
- 6
- Pages
- 837-842
- ISSN
- 0891-5849 (ISSN-L)
- OpenAlex
- W2036857026
- Cited by
- 21
- References
- 20
- Citations by year
- 2023: 1 · 2021: 1 · 2020: 1 · 2018: 1
- FWCI
- 0.61
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Free Radical Biology and Medicine (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Energy
- Basic Energy Sciences
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Free Radicals and Antioxidants
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Electron Spin Resonance Studies
- Keywords
- tryptophan radical, superoxide, superoxide dismutase, one-electron oxidation, bromide radical, diffusion-controlled reaction, rate constants
- MeSH terms
- Anions, Bromine, Diffusion, Kinetics, Oxidation-Reduction, Pulse Radiolysis, Superoxides, Superoxide Dismutase, Tryptophan
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