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Fluoxetine and Oculomotor Activity during Sleep in Depressed Patients
Abstract
The effects of fluoxetine on automated measures of electrooculographic (EOG) and electromyographic (EMG) activity were evaluated in 41 patients with nonpsychotic, major depressive disorder. Sleep EEG evaluations were conducted at baseline, while patients were symptomatic and unmedicated, and following four to five weeks of treatment with fluoxetine (20 mg). The number of eye movements (> 75 microV) and the amplitude of EOG and EMG activity increased significantly on treatment in REM, stages 1, 2, and slow-wave sleep. All patients showed EOG and EMG abnormalities in at least one stage of sleep. Thirty-four percent of patients showed increased EOG and EMG activity on treatment in every sleep stage. It is suggested that fluoxetine-induced oculomotor abnormalities are likely to be the result of increased availability of serotonin and secondary dopaminergic effects.
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Fluoxetine use is associated with an increased number of oculomotor movements during non-rapid eye movement (NREM) sleep.
“An additional sleep physiology phenomenon has been reported with fluoxetine use; that of an increased number of oculomotor movements during non-rapid eye movement (NREM) sleep [Keck et al., 1991;Schenck et al., 1992;Armitage et al., 1995;Dorsey and Lukas, 1996].”
From Depression, sleep physiology, and antidepressant drugs (2001) · cites this paper as Armitage et al., 1995
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Depression, sleep physiology, and antidepressant drugs
Winokur, A., Gary, K. A., Rodner, S., Rae-Red, C., Fernando, A. T., & Szuba, M. P. (2001) · Depression and Anxiety · doi:10.1002/da.1043 · Cited by 179
Parasomnias and Antidepressant Therapy: A Review of the Literature
Kierlin, L., & Littner, M. R. (2011) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2011.00071 · Cited by 55
Effects of Antidepressant Treatment on Sleep EEG in Depression
Armitage, R. (1996) · Journal of Psychopharmacology · doi:10.1177/026988119601001s01 · Cited by 18
Self-citationPace-Schott, E. F. (2008) · Serotonin and Sleep: Molecular, Functional and Clinical Aspects · doi:10.1007/978-3-7643-8561-3_12 · Cited by 8
Metadata
- Authors
- Armitage, R.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Corresponding author
- Armitage, R
- Venue
- Neuropsychopharmacology
- Published
- 1995-04
- Volume
- 12
- Issue
- 2
- Pages
- 159-165
- ISSN
- 0893-133X (ISSN-L)
- OpenAlex
- W2047622527
- Cited by
- 60
- References
- 0
- Citations by year
- 2025: 1 · 2024: 1 · 2022: 1 · 2020: 2 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 1 · 2015: 2 · 2014: 4 · 2013: 2
- FWCI
- 1.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuropsychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (P50MH041115)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Keywords
- fluoxetine, major depressive disorder, oculomotor behavior, eye movements, electrooculography, electromyography, sleep, REM sleep, slow-wave sleep, serotonin, dopaminergic effects, antidepressant side effects
- MeSH terms
- Adolescent, Adult, Aged, Ambulatory Care, Depression, Electroencephalography, Electromyography, Electrooculography, Eye Movements, Female, Fluoxetine, Humans, Male, Middle Aged, Sleep, Sleep Wake Disorders, Sleep, REM, Ocular Motility Disorders
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