The DOI matches its Crossref record; 45 of the 46 references it cites were found in a registry or an index.
The organization of cytoplasm at the presynaptic active zone of a central nervous system synapse
Abstract
The axoplasm at the presynaptic active zone of excitatory synapses between parallel fibers and Purkinje cell spines contains a meshwork of distinct filaments intermingled with synaptic vesicles, seen most clearly after the rapid freezing, freeze-etch technique of tissue preparation. One set of filaments extends radially from synaptic vesicles and intersects similar filaments associated with vesicles as well as larger filaments arising from the presynaptic membrane. The small, vesicle-associated filaments appear to link synaptic vesicles to one another and to enmesh them in the vicinity of the synaptic junction. The vesicle-associated filaments could be synapsin I because they have the same molecular dimensions and are distributed in the same pattern as synapsin I immunoreactivity.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In cryo-EM studies of unfixed and unstained synapse preparations, however, no dense projections are detectable. The only structures visible are the plasma membrane, synaptic vesicles, and sparse filaments that either connect vesicles to each others (“connectors,” average length ~10 nm) or tether vesicles to the presynaptic plasma membrane (“tethers”—5–20 nm; Landis et al., 1988; Fernández-Busnadie”
From The Presynaptic Active Zone (2012) · cites this paper as Landis et al., 1988
Citations
Cites
Heuser, J. E., & Reese, T. S. (1973) · The Journal of Cell Biology · doi:10.1083/jcb.57.2.315 · Cited by 2,147
Self-citationThe Fine Structure of the Nervous System.
Tennyson, V. M. (1970) · Archives of Neurology · doi:10.1001/archneur.1970.00480240094019 · Cited by 1,946
Heuser, J. E., Reese, T. S., Dennis, M., Jan, Y., Jan, L., & Evans, L. (1979) · Journal of Cell Biology · doi:10.1083/jcb.81.2.275 · Cited by 1,394
Self-citationHuttner, W. Β., SCHIEBLER, W., Greengard, P., & Camilli, P. V. D. (1983) · The Journal of Cell Biology · doi:10.1083/jcb.96.5.1374 · Cited by 1,172
fine structure of the nervous system
Peters, A., Palay, S. L., & Webster, H. D. (1976) · Cited by 796
Relationship between presynaptic calcium current and postsynaptic potential in squid giant synapse
Llinas, R. H., Steinberg, I. Z., & Walton, K. D. (1981) · Biophysical Journal · doi:10.1016/s0006-3495(81)84899-0 · Cited by 706
Aghajanian, G. K., & Bloom, F. E. (1967) · Brain Research · doi:10.1016/0006-8993(67)90128-x · Cited by 667
Llinas, R. H., McGuinness, T. L., Leonard, C. S., Sugimori, M., & Greengard, P. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.9.3035 · Cited by 641
Three-dimensional visualization of coated vesicle formation in fibroblasts.
Heuser, J. E. (1980) · The Journal of Cell Biology · doi:10.1083/jcb.84.3.560 · Cited by 580
Camilli, P. V. D., Cameron, R. S., & Greengard, P. (1983) · The Journal of Cell Biology · doi:10.1083/jcb.96.5.1337 · Cited by 554
Research works printed but not linked: 1
- Couteaux, 1970, Vesicules synaptiques et poches au niveau des “zones actives” de la junction neuromusculaire, Compt. Rend., 271, 2346
Cited by
Sorted by citations
SNAP receptors implicated in vesicle targeting and fusion
Söllner, T. H., Whiteheart, S. W., Brunner, M., Erdjument‐Bromage, H., Geromanos, S. J., Tempst, P., & Rothman, J. E. (1993) · Nature · doi:10.1038/362318a0 · Cited by 3,239
The synaptic vesicle cycle: a cascade of protein–protein interactions
Südhof, T. C. (1995) · Nature · doi:10.1038/375645a0 · Cited by 1,991
Synaptic Vesicle Phosphoproteins and Regulation of Synaptic Function
Greengard, P., Valtorta, F., Czernik, A. J., & Benfenati, F. (1993) · Science · doi:10.1126/science.8430330 · Cited by 1,311
Syntaxin: A Synaptic Protein Implicated in Docking of Synaptic Vesicles at Presynaptic Active Zones
Bennett, M. K., Calakos, N., & Scheller, R. H. (1992) · Science · doi:10.1126/science.1321498 · Cited by 1,263
Südhof, T. C. (2012) · Neuron · doi:10.1016/j.neuron.2012.06.012 · Cited by 1,062
Metadata
- Authors
- Landis, D. M. D., Hall, A. K., Weinstein, L. A., & Reese, T. S.
- Affiliations
- Case Western Reserve University (US)
- National Institutes of Health (US)
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 1988-05
- Volume
- 1
- Issue
- 3
- Pages
- 201-209
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2024032585
- Cited by
- 333
- References
- 46
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 4 · 2023: 6 · 2022: 4 · 2021: 6 · 2020: 3 · 2019: 8 · 2018: 10 · 2017: 9 · 2016: 4 · 2015: 7 · 2014: 12 · 2013: 10 · 2012: 12
- FWCI
- 5.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (NS 23641)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Keywords
- active zone, axoplasm, synaptic vesicles, parallel fibers, synapsin I, cytoskeletal filaments, synapses, excitatory synapses, central nervous system synapses
- MeSH terms
- Animals, Cerebellum, Cytoplasm, Mice, Inbred C57BL, Microscopy, Electron, Nerve Tissue Proteins, Synapses, Synapsins, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
