Cited by 150Nerve injury and regenerationAxon Guidance and Neuronal SignalingNeurogenesis and neuroplasticity mechanisms

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Cloning of human GAP 43: Growth association and ischemic resurgence

Ng, Shi-Chung, de la Monte, Suzanne M., Conboy, Gary L., Karns, Larry R., Fishman, Mark C.·1988·Neuron

DOI 10.1016/0896-6273(88)90197-3

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Abstract

GAP-43 is a growth cone protein expressed in neurons especially during periods of axonal elongation. Poor repair in the adult mammalian CNS has been ascribed to restraints upon its expression. We have cloned human GAP-43 cDNA to investigate its potential involvement in neurological illness. Analysis of postmortem human brain tissue disclosed uniformly high expression of GAP-43 throughout the neonatal brain, whereas in the adult brain high levels of GAP-43 persist only in discrete regions. However, in the wake of ischemic injury in the adult brain, regions normally low in GAP-43 reexpress it at high levels, suggesting a role for GAP-43 in remodeling and repair of mature CNS neurons.

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Additional file 1 of Phosphorylation of GAP-43 T172 is a molecular marker of growing axons in a wide range of mammals including primates
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Additional file 2 of Phosphorylation of GAP-43 T172 is a molecular marker of growing axons in a wide range of mammals including primates
Okada, M., Kawagoe, Y., Sato, Y., Nozumi, M., Ishikawa, Y., Tamada, A., Yamazaki, H., Sekino, Y., Kanemura, Y., Shinmyo, Y., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14391027
Additional file 7 of Phosphorylation of GAP-43 T172 is a molecular marker of growing axons in a wide range of mammals including primates
Okada, M., Kawagoe, Y., Sato, Y., Nozumi, M., Ishikawa, Y., Tamada, A., Yamazaki, H., Sekino, Y., Kanemura, Y., Shinmyo, Y., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14391042
Additional file 4 of Phosphorylation of GAP-43 T172 is a molecular marker of growing axons in a wide range of mammals including primates
Okada, M., Kawagoe, Y., Sato, Y., Nozumi, M., Ishikawa, Y., Tamada, A., Yamazaki, H., Sekino, Y., Kanemura, Y., Shinmyo, Y., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14391033
Additional file 3 of Phosphorylation of GAP-43 T172 is a molecular marker of growing axons in a wide range of mammals including primates
Okada, M., Kawagoe, Y., Sato, Y., Nozumi, M., Ishikawa, Y., Tamada, A., Yamazaki, H., Sekino, Y., Kanemura, Y., Shinmyo, Y., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14391030
Additional file 8 of Phosphorylation of GAP-43 T172 is a molecular marker of growing axons in a wide range of mammals including primates
Okada, M., Kawagoe, Y., Sato, Y., Nozumi, M., Ishikawa, Y., Tamada, A., Yamazaki, H., Sekino, Y., Kanemura, Y., Shinmyo, Y., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14391045
Additional file 5 of Phosphorylation of GAP-43 T172 is a molecular marker of growing axons in a wide range of mammals including primates
Okada, M., Kawagoe, Y., Sato, Y., Nozumi, M., Ishikawa, Y., Tamada, A., Yamazaki, H., Sekino, Y., Kanemura, Y., Shinmyo, Y., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14391036
Additional file 6 of Phosphorylation of GAP-43 T172 is a molecular marker of growing axons in a wide range of mammals including primates
Okada, M., Kawagoe, Y., Sato, Y., Nozumi, M., Ishikawa, Y., Tamada, A., Yamazaki, H., Sekino, Y., Kanemura, Y., Shinmyo, Y., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14391039
Untitled work
Mattson, M. (1999) · doi:10.1002/(sici)1097-4547(19991001)58:1

Authors: Ng, S.-C., de la Monte, S. M., Conboy, G. L., Karns, L. R., & Fishman, M. C.
Affiliations: Howard Hughes Medical Institute (US)
Harvard University (US)
ORCID: de la Monte, Suzanne M.
Fishman, Mark C.
Venue: Neuron
Publisher: Elsevier BV
Published: 1988-04
Volume: 1
Issue: 2
Pages: 133-139
ISSN: 0896-6273 (ISSN-L)
DOI: 10.1016/0896-6273(88)90197-3
OpenAlex: W2054092941
Cited by: 150
References: 41
Citations by year: 2025: 4 · 2024: 1 · 2022: 1 · 2021: 9 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 1 · 2015: 2 · 2014: 2 · 2013: 4 · 2012: 1
FWCI: 6.85
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuron (publishedVersion)
PubMed (publishedVersion)
Funders: Howard Hughes Medical Institute
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords: GAP-43, growth-associated protein, cDNA cloning, growth cones, axon elongation, CNS repair, ischemic injury, neuronal remodeling, postmortem brain, neonatal brain, neurological disorders
MeSH terms: Adolescent, Aging, Amino Acid Sequence, Base Sequence, Brain, Cerebral Infarction, DNA, Humans, Infant, Newborn, Membrane Glycoproteins, Middle Aged, Molecular Sequence Data, Nerve Tissue Proteins, GAP-43 Protein

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Cloning of human GAP 43: Growth association and ischemic resurgence

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