The DOI matches its Crossref record; 39 of the 41 references it cites were found in a registry or an index.
Cloning of human GAP 43: Growth association and ischemic resurgence
Abstract
GAP-43 is a growth cone protein expressed in neurons especially during periods of axonal elongation. Poor repair in the adult mammalian CNS has been ascribed to restraints upon its expression. We have cloned human GAP-43 cDNA to investigate its potential involvement in neurological illness. Analysis of postmortem human brain tissue disclosed uniformly high expression of GAP-43 throughout the neonatal brain, whereas in the adult brain high levels of GAP-43 persist only in discrete regions. However, in the wake of ischemic injury in the adult brain, regions normally low in GAP-43 reexpress it at high levels, suggesting a role for GAP-43 in remodeling and repair of mature CNS neurons.
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In the citing paper
“After stroke, axonal sprouting has been demonstrated in mice, rats and non-human primates1–4,10,38.”
From GDF10 is a signal for axonal sprouting and functional recovery after stroke (2015) · cites this paper as [38]
In the citing paper
“PTEN inhibition potentiates axonal sprouting in optic nerve injury and spinal cord injury, through induction of PI3kinase signaling and activation of mTOR.”
From GDF10 is a signal for axonal sprouting and functional recovery after stroke (2015) · cites this paper as [38]
In the citing paper
“Inhibition of SOCS3 further promotes axonal sprouting on top of PTEN inhibition8,37,38.”
From GDF10 is a signal for axonal sprouting and functional recovery after stroke (2015) · cites this paper as [38]
Citations
Cites
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Pain and Its Effects in the Human Neonate and Fetus
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Cited by
Sorted by citations
Plasticity during stroke recovery: from synapse to behaviour
Murphy, T. H., & Corbett, D. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2735 · Cited by 1,938
Brain–computer interfaces in neurological rehabilitation
Daly, J. J., & Wolpaw, J. R. (2008) · The Lancet Neurology · doi:10.1016/s1474-4422(08)70223-0 · Cited by 1,149
Axonal Growth-Associated Proteins
Skene, J. H. P. (1989) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.12.030189.001015 · Cited by 1,145
Cellular and molecular mechanisms of neural repair after stroke: making waves
Carmichael, S. T. (2006) · Annals of Neurology · doi:10.1002/ana.20845 · Cited by 595
Stroemer, R. P., Kent, T. A., & Hulsebosch, C. E. (1995) · Stroke · doi:10.1161/01.str.26.11.2135 · Cited by 514
Metadata
- Authors
- Ng, S.-C., de la Monte, S. M., Conboy, G. L., Karns, L. R., & Fishman, M. C.
- Affiliations
- Howard Hughes Medical Institute (US)
- Harvard University (US)
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 1988-04
- Volume
- 1
- Issue
- 2
- Pages
- 133-139
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2054092941
- Cited by
- 150
- References
- 41
- Citations by year
- 2025: 4 · 2024: 1 · 2022: 1 · 2021: 9 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 1 · 2015: 2 · 2014: 2 · 2013: 4 · 2012: 1
- FWCI
- 6.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Howard Hughes Medical Institute
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- GAP-43, growth-associated protein, cDNA cloning, growth cones, axon elongation, CNS repair, ischemic injury, neuronal remodeling, postmortem brain, neonatal brain, neurological disorders
- MeSH terms
- Adolescent, Aging, Amino Acid Sequence, Base Sequence, Brain, Cerebral Infarction, DNA, Humans, Infant, Newborn, Membrane Glycoproteins, Middle Aged, Molecular Sequence Data, Nerve Tissue Proteins, GAP-43 Protein
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