Organization of hindbrain segments in the zebrafish embryo
Abstract
To learn how neural segments are structured in a simple vertebrate, we have characterized the embryonic zebrafish hindbrain with a library of monoclonal antibodies. Two regions repeat in an alternating pattern along a series of seven segments. One, the neuromere centers, contains the first basal plate neurons to develop and the first neuropil. The other region, surrounding the segment boundaries, contains the first neurons to develop in the alar plate. The projection patterns of these neurons differ: those in the segment centers have descending axons, while those in the border regions form ventral commissures. A row of glial fiber bundles forms a curtain-like structure between each center and border region. Specific features of the individual hindbrain segments in the series arise within this general framework. We suggest that a cryptic simplicity underlies the eventual complex structure that develops from this region of the CNS.
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“Only one gene, alcama (also dm-grasp or neurolin-a), the target of the zn-5/8 monoclonal antibody [56], [57] was enriched in both RPE and iridophores when compared to melanocytes and whole embryos (Table S8).”
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- Authors
- Trevarrow, B., Marks, D. L., & Kimmel, C. B.
- Affiliations
- University of Oregon (US)
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 1990-05
- Volume
- 4
- Issue
- 5
- Pages
- 669-679
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W1983319708
- Cited by
- 506
- References
- 0
- Citations by year
- 2026: 2 · 2025: 1 · 2023: 4 · 2022: 9 · 2021: 8 · 2020: 6 · 2019: 6 · 2018: 6 · 2017: 7 · 2016: 14 · 2015: 12 · 2014: 10 · 2013: 21 · 2012: 16
- FWCI
- 5.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of General Medical Sciences (T32 GMO 7413)
- National Institute of Neurological Disorders and Stroke (NS17963, R01NS017963)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Zebrafish Biomedical Research Applications
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- alar plate, descending axons, monoclonal antibodies, embryonic development
- MeSH terms
- Animals, Antibodies, Monoclonal, Axons, Cyprinidae, Cytoplasm, Dendrites, Immunohistochemistry, Neuroglia, Neurons, Rhombencephalon, Zebrafish
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