An extended family of protein-tyrosine kinase genes differentially expressed in the vertebrate nervous system

We have used PCR to identify 13 novel protein-tyrosine kinase genes (tyro-1 to -13), six of which (tyro-1 to -6) are preferentially expressed in the developing vertebrate nervous system. The tyro-2 and tyro-9 genes encode kinase domains that exhibit strong amino acid sequence similarity to the eq…