The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Trk receptors use redundant signal transduction pathways involving SHC and PLC-γ1 to mediate NGF responses
Open accessAbstract
In response to NGF, the Trk receptor tyrosine kinase forms a complex with SHC, a protein that couples receptor tyrosine kinases to p21ras. Complex formation between Trk and SHC, SHC tyrosine phosphorylation, and association of SHC with Grb2 were mediated by autophosphorylation at Y490 in Trk [sequence: see text]. To determine the role of SHC and other Trk substrates in NGF signaling, Trk receptors with mutations in Y490 and Y785 (the PLC-gamma 1 association site) were introduced into PC12nnr5 cells. NGF treatment of PC12nnr5 cells expressing Trk with mutations in either substrate-binding site resulted in normal neurite outgrowth and Erk1 activity and tyrosine phosphorylation. However, PC12nnr5 cells expressing Trk with mutations at both sites failed to stably extend neurites and efficiently induce Erk1 activity and tyrosine phosphorylation in response to NGF. We postulate that Trk receptors can activate Erk1 by either SHC- or PLC-gamma 1-dependent signaling pathways. These results suggest a model whereby Trk receptors utilize at least partially redundant signal transduction pathways to mediate NGF responses.
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Cites
Trophic factors and neuronal survival
Barde, Y.-A. (1989) · Neuron · doi:10.1016/0896-6273(89)90040-8 · Cited by 1,625
The trk Proto-Oncogene Product: a Signal Transducing Receptor for Nerve Growth Factor
Kaplan, D. R., Hempstead, B. L., Martin-Zanca, D., Chao, M. V., & Parada, L. F. (1991) · Science · doi:10.1126/science.1850549 · Cited by 1,379
Self-citation
Cited by
Neurotrophins: Roles in Neuronal Development and Function
Huang, E. J., & Reichardt, L. F. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.677 · Cited by 4,394
Marshall, C. J. (1995) · Cell · doi:10.1016/0092-8674(95)90401-8 · Cited by 3,906
Trk Receptors: Roles in Neuronal Signal Transduction
Huang, E. J., & Reichardt, L. F. (2003) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.72.121801.161629 · Cited by 2,537
Grasping objects: the cortical mechanisms of visuomotor transformation
Jeannerod, M., Arbib, M. A., Rizzolatti, G., & Sakata, H. (1995) · Trends in Neurosciences · doi:10.1016/0166-2236(95)93921-j · Cited by 1,399
Lev, S., Moreno, H., Martinez, R., Canoll, P., Peles, E., Musacchio, J. M., Plowman, G. D., Rudy, B., & Schlessinger, J. (1995) · Nature · doi:10.1038/376737a0 · Cited by 1,381
Metadata
- Authors
- Stephens, R. M., Loeb, D. M., Copeland, T. D., Pawson, T., Greene, L. A., & Kaplan, D. R.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 1994-03
- Volume
- 12
- Issue
- 3
- Pages
- 691-705
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2040620685
- Cited by
- 541
- References
- 2
- FWCI
- 16.83
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Stephens, R. M., Loeb, D. M., Copeland, T. D., Pawson, T., Greene, L. A., & Kaplan, D. R. (1994). Trk receptors use redundant signal transduction pathways involving SHC and PLC-γ1 to mediate NGF responses. Neuron. https://doi.org/10.1016/0896-6273(94)90223-2
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