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Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation

Marshall, C.J·1995·Cell
DOI 10.1016/0092-8674(95)90401-8
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Abstract

A number of different intracellular signaling pathways have been shown to be activated by receptor tyrosine kinases. These activation events include the phosphoinositide 3-kinase, 70 kDa S6 kinase, mitogen-activated protein kinase (MAPK), phospholipase C-gamma, and the Jak/STAT pathways. The precise role of each of these pathways in cell signaling remains to be resolved, but studies on the differentiation of mammalian PC12 cells in tissue culture and the genetics of cell fate determination in Drosophila and Caenorhabditis suggest that the extracellular signal-regulated kinase (ERK-regulated) MAPK pathway may be sufficient for these cellular responses. Experiments with PC12 cells also suggest that the duration of ERK activation is critical for cell signaling decisions.

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Metadata

Authors
Marshall, C. J.
Venue
Cell
Publisher
Elsevier BV
Published
1995-01
Volume
80
Issue
2
Pages
179-185
ISSN
0092-8674
DOI
10.1016/0092-8674(95)90401-8
Cited by
3,906
References
2
Language
en
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