The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Receptor tyrosine kinase specific for the skeletal muscle lineage: Expression in embryonic muscle, at the neuromuscular junction, and after injury
Open accessAbstract
While a number of growth factors have been described that are highly specific for particular cell lineages, neither a factor nor a receptor uniquely specific to the skeletal muscle lineage has previously been described. Here we identify a receptor tyrosine kinase (RTK) specific to skeletal muscle, which we term "MuSK" for muscle-specific kinase. MuSK is expressed at low levels in proliferating myoblasts and is induced upon differentiation and fusion. In the embryo, it is specifically expressed in early myotomes and developing muscle. MuSK is then dramatically down-regulated in mature muscle, where it remains prominent only at the neuromuscular junction; MuSK is thus the only known RTK that localizes to the neuromuscular junction. Strikingly, MuSK expression is dramatically induced throughout the adult myofiber after denervation, block of electrical activity, or physical immobilization. In humans, MuSK maps to chromosome 9q31.3-32, which overlaps with the region reported to contain the Fukuyama muscular dystrophy mutation. Identification of MuSK introduces a novel receptor-factor system that seems sure to play an important and selective role in many aspects of skeletal muscle development and function.
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Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium
Fong, G.-H., Rossant, J., Gertsenstein, M., & Breitman, M. L. (1995) · Nature · doi:10.1038/376066a0 · Cited by 2,606
Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation
Sato, T. N., Tozawa, Y., Deutsch, U., Wolburg-Buchholz, K., Fujiwara, Y., Gendron-Maguire, M., Gridley, T., Wolburg, H., Risau, W., & Qin, Y. (1995) · Nature · doi:10.1038/376070a0 · Cited by 1,820
Growth factor signaling by receptor tyrosine kinases
Schlessinger, J., & Ullrich, A. (1992) · Neuron · doi:10.1016/0896-6273(92)90177-f · Cited by 1,430
Functions of the neurotrophins during nervous system development: What the knockouts are teaching us
Snider, W. D. (1994) · Cell · doi:10.1016/0092-8674(94)90048-5 · Cited by 1,428
Hanks, S. K., & Quinn, A. M. (1991) · Methods in Enzymology · doi:10.1016/0076-6879(91)00126-h · Cited by 1,217
Synaptic structure and development: The neuromuscular junction
Hall, Z. W., & Sanes, J. R. (1993) · Cell · doi:10.1016/s0092-8674(05)80031-5 · Cited by 834
Stitt, T. N., Conn, G., Goret, M., Lai, C., Bruno, J., Radzlejewski, C., Mattsson, K., Fisher, J., Gies, D. R., Jones, P. F., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90520-0 · Cited by 730
Self-citationMcMahan, U. J. (1990) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1990.055.01.041 · Cited by 641
Falls, D. (1993) · Cell · doi:10.1016/0092-8674(93)90407-h · Cited by 607
Cytokine Receptors and Signal Transduction
Miyajima, A., Kitamura, T., Harada, N., Yokota, T., & Arai, K.-I. (1992) · Annual Review of Immunology · doi:10.1146/annurev.iy.10.040192.001455 · Cited by 605
Cited by
DEVELOPMENT OF THE VERTEBRATE NEUROMUSCULAR JUNCTION
Sanes, J. R., & Lichtman, J. W. (1999) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.22.1.389 · Cited by 1,532
Autoimmune myasthenia gravis: emerging clinical and biological heterogeneity
Meriggioli, M. N., & Sanders, D. B. (2009) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70063-8 · Cited by 894
Utrophin–dystrophin-deficient mice as a model for Duchenne muscular dystrophy
Deconinck, A. E., Rafael, J. A., Skinner, J. A., Brown, S. C., Potter, A. C., Metzinger, L., Watt, D. J., Dickson, J. G., Tinsley, J. M., & Davies, K. E. (1997) · Cell · doi:10.1016/s0092-8674(00)80532-2 · Cited by 752
Lrp4 is a receptor for Agrin and forms a complex with MuSK
Kim, N., Stiegler, A. L., Cameron, T. O., Hallock, P. T., Gomez, A. M., Huang, J. H., Hubbard, S. R., Dustin, M. L., & Burden, S. J. (2008) · Cell · doi:10.1016/j.cell.2008.10.002 · Cited by 676
Self-citationLaporte, J., Hu, L. J., Kretz, C., Mandel, J.-L., Kioschis, P., Coy, J. F., Klauck, S. M., Poustka, A., & Dahl, N. (1996) · Nature Genetics · doi:10.1038/ng0696-175 · Cited by 639
Metadata
- Authors
- Valenzuela, D. M., Stitt, T. N., DiStefano, P. S., Rojas, E., Mattsson, K., Compton, D. L., Nunez, L., Park, J. S., Stark, J. L., Gies, D. R., Thomas, S., Le Beau, M. M., Fernald, A. A., Copeland, N. G., Jenkins, N. A., Burden, S. J., Glass, D. J., & Yancopoulos, G. D.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 1995-09
- Volume
- 15
- Issue
- 3
- Pages
- 573-584
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2057313033
- Cited by
- 417
- References
- 36
- FWCI
- 9.24
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Receptor tyrosine kinase specific for the skeletal muscle lineage: Expression in embryonic muscle, at the neuromuscular junction, and after injury. https://app.cochat.ai/papers/10.1016/0896-6273(95)90146-9
- The paper
- Valenzuela, D. M., Stitt, T. N., DiStefano, P. S., Rojas, E., Mattsson, K., Compton, D. L., Nunez, L., Park, J. S., Stark, J. L., Gies, D. R., Thomas, S., Le Beau, M. M., Fernald, A. A., Copeland, N. G., Jenkins, N. A., Burden, S. J., Glass, D. J., & Yancopoulos, G. D. (1995). Receptor tyrosine kinase specific for the skeletal muscle lineage: Expression in embryonic muscle, at the neuromuscular junction, and after injury. Neuron. https://doi.org/10.1016/0896-6273(95)90146-9
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