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Ion fluxes associated with excitatory amino acid transport
Open accessAbstract
Flux of substrate and charge mediated by three cloned excitatory amino acid transporters widely expressed in human brain were studied in voltage-clamped Xenopus oocytes. Superfusion of L-glutamate or D-aspartate resulted in currents due in part to electrogenic Na+ cotransport, which contributed 1 net positive charge per transport cycle. A significant additional component of the currents was due to activation of a reversible anion flux that was not thermodynamically coupled to amino acid transport. The selectivity sequence of this ligand-activated conductance was NO3- > 1- > Br- > Cl- > F-. The results suggest that these proteins mediate both transporter- and channel-like modes of permeation, providing a potential mechanism for dampening cell excitability, in addition to removal of transmitter.
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Cited by
Danbolt, N. C. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00067-8 · Cited by 4,227
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Jentsch, T. J., Stein, V., Weinreich, F., & Zdebik, A. A. (2002) · Physiological Reviews · doi:10.1152/physrev.00029.2001 · Cited by 1,256
Mahmoud, S., Gharagozloo, M., Simard, C., & Gris, D. (2019) · Cells · doi:10.3390/cells8020184 · Cited by 698
Beyond the role of glutamate as a neurotransmitter
Nedergaard, M., Takano, T., & Hansen, A. J. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn916 · Cited by 450
Kanai, Y., & Hediger, M. A. (2004) · Pfl�gers Archiv European Journal of Physiology · doi:10.1007/s00424-003-1146-4 · Cited by 450
Metadata
- Authors
- Wadiche, J. I., Amara, S. G., & Kavanaugh, M. P.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 1995-09
- Volume
- 15
- Issue
- 3
- Pages
- 721-728
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2078310394
- Cited by
- 539
- References
- 0
- FWCI
- 18.99
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Wadiche, J. I., Amara, S. G., & Kavanaugh, M. P. (1995). Ion fluxes associated with excitatory amino acid transport. Neuron. https://doi.org/10.1016/0896-6273(95)90159-0
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