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Cited by 87Schizophrenia research and treatmentAutoimmune Neurological Disorders and TreatmentsSystemic Lupus Erythematosus Research

Increased prevalence of antibrain antibodies in the sera from schizophrenic patients

Henneberg, A.E., Horter, S., Ruffert, S.·1994·Schizophrenia Research
DOI 10.1016/0920-9964(94)90004-3
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Abstract

The pathogenesis of schizophrenia is still unknown. In a previous study we found antibrain antibodies in the sera of schizophrenic patients, but not in normal controls. Therefore we have further examined the sera of schizophrenic patients versus normal controls, increasing the number of brain areas, to explore whether certain areas were involved more often than others in the antibody binding process. The sera of 50 patients suffering from an acute episode of schizophrenia (classified by DSM III-criteria) were tested. 70% of the patients showed antibody binding, while only 12% of the age- and sex-matched controls were positive. The binding was mediated by IgG- as well as IgM-antibodies. Amygdala, frontal cortex, cingulate gyrus, and septal area were the prominent targets, while hippocampus, parahippocampal gyrus, entorhinal cortex, putamen, mamillary bodies and head of the caudate nucleus were involved to a lesser degree. Binding was not present to nucleus olivaris, to the thyroid gland or to HEp-2 cells, which we included to test for unspecific antinuclear factors. Longterm studies of schizophrenic patients and biochemical analyses of the antigen(s) involved are in progress.

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  • Numerous studies have reported circulating anti-brain immunoglobulins in patients with ASD and in related conditions such as multiple sclerosis, schizophrenia, and systemic lupus erythematosus.

    “numerous studies have reported the presence of circulating anti-brain immunoglobulins in patients with ASD, as well as related conditions such as multiple sclerosis (Ryberg, 1982), schizophrenia (Henneberg et al, 1994), and systemic lupus erythematosus (SLE) (Libbey and Fujinami, 2010;Mackay et al, 2015;Suurmond and Diamond, 2015).”

    From The Role of the Immune System in Autism Spectrum Disorder (2017) · cites this paper as Henneberg et al, 1994

  • Autoantibodies are associated with other neurological disorders, including schizophrenia and multiple sclerosis.

    “Given the existence of autoantibodies associated with other neurological disorders such as schizophrenia (Henneberg et al, 1994) and multiple sclerosis (Ryberg, 1982)”

    From The Role of the Immune System in Autism Spectrum Disorder (2017) · cites this paper as Henneberg et al, 1994

  • Autoantibodies such as those described have been found in patients with other autoimmune disorders, including multiple sclerosis, schizophrenia, and SLE.

    “Autoantibodies, such as those described above, have been found in patients of other autoimmune disorders, including multiple sclerosis (Ryberg, 1982), schizophrenia (Henneberg et al, 1994), and SLE (Libbey and Fujinami, 2010).”

    From The Role of the Immune System in Autism Spectrum Disorder (2017) · cites this paper as Henneberg et al, 1994

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Authors
Henneberg, A. E., Horter, S., & Ruffert, S.
Affiliations
Universität Ulm (DE)
Corresponding author
Henneberg, A.E.
Venue
Schizophrenia Research
Publisher
Elsevier BV
Published
1994-12
Volume
14
Issue
1
Pages
15-22
ISSN
0920-9964 (ISSN-L)
DOI
10.1016/0920-9964(94)90004-3
OpenAlex
W2092358878
Cited by
87
References
81
Citations by year
2024: 1 · 2022: 2 · 2021: 1 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 4 · 2015: 1 · 2014: 5 · 2013: 8 · 2012: 3
FWCI
1.78
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Schizophrenia Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
Universität Ulm
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Health Sciences › Medicine › Neurology › Autoimmune Neurological Disorders and Treatments
  • Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
Keywords
anti-brain antibodies, schizophrenia
MeSH terms
Acute Disease, Adult, Antibody Specificity, Autoantibodies, Autoimmune Diseases, Binding Sites, Antibody, Brain, Brain Mapping, Cell Line, Female, Humans, Immunoglobulin G, Immunoglobulin M, Male, Middle Aged, Schizophrenia, Schizophrenic Psychology

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