The role of poly(A) in the translation and stability of mRNA
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The poly(A) region contributes to translation efficiency, mRNA half-life, and therefore mRNA potency.
“The poly(A) is a critical region that contributes to translation efficiency, mRNA half-life, and therefore mRNA potency.19”
From Combining an optimized mRNA template with a double purification process allows strong expression of in vitro transcribed mRNA (2021) · cites this paper as [19]
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Trepotec, Z., Geiger, J., Plank, C., Aneja, M. K., & Rudolph, C. (2019) · RNA · doi:10.1261/rna.069286.118 · Cited by 129 · see citing works
3′ UTR lengthening as a novel mechanism in regulating cellular senescence.
Chen, M., Lyu, G., Han, M., Nie, H., Shen, T., Chen, W., Niu, Y., Song, Y., Li, X., Li, H., et al. (2018) · Genome Research · doi:10.1101/gr.224451.117 · Cited by 111 · see citing works
Linares-Fernández, S., Moreno, J., Lambert, E., Mercier-Gouy, P., Vachez, L., Verrier, B., & Exposito, J.-Y. (2021) · Molecular Therapy - Nucleic Acids · doi:10.1016/j.omtn.2021.10.007 · Cited by 62 · see citing works
Improved translation efficiency of injected mRNA during early embryonic development
Fink, M., Flekna, G., Ludwig, A., Heimbucher, T., & Czerny, T. (2006) · Developmental Dynamics · doi:10.1002/dvdy.20995 · Cited by 40 · see citing works
Recognition of Poly(A) RNA through Its Intrinsic Helical Structure
Tang, T. T. L., & Passmore, L. A. (2019) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2019.84.039818 · Cited by 29 · see citing works
- Authors
- Sachs, A.
- Affiliations
- Whitehead Institute for Biomedical Research (US)
- Corresponding author
- Sachs, A.
- Venue
- Current Opinion in Cell Biology
- Publisher
- Elsevier BV
- Published
- 1990-12
- Volume
- 2
- Issue
- 6
- Pages
- 1092-1098
- ISSN
- 0955-0674 (ISSN-L)
- OpenAlex
- W2080940607
- Cited by
- 155
- References
- 0
- Citations by year
- 2025: 3 · 2024: 2 · 2023: 3 · 2022: 4 · 2021: 9 · 2020: 2 · 2019: 4 · 2018: 3 · 2017: 6 · 2016: 2 · 2015: 2 · 2014: 2 · 2013: 3 · 2012: 1
- FWCI
- 1.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of General Medical Sciences (GM43164, R29GM043164)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA modifications and cancer
- Keywords
- poly(A) tail, mRNA stability, translation (biology), poly(A)-binding protein, mRNA degradation, cap-independent translation
- MeSH terms
- Animals, Cytoplasm, Poly A, Ribonucleoproteins, RNA, Messenger, Protein Biosynthesis, Molecular Structure
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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