Cited by 145

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Angiogenic growth factors.

Risau, Werner·1990·Progress in Growth Factor Research

Abstract

Angiogenesis, the formation of new blood vessels, plays a central role in a variety of physiological and pathological processes such as embryonic development, wound healing and tumor growth. It is a complex, multi-step process that involves the migration and proliferation of capillary endothelial cells. Several factors that stimulate the proliferation of endothelial cells in vitro have been shown to induce angiogenesis in vivo. Among these angiogenic growth factors are wide-spectrum multifunctional mitogens (e.g. the fibroblast growth factors) and the recently identified factors with distinct specificity for vascular endothelial cells (e.g. the platelet-derived endothelial cell growth factor). Another group of factors apparently induce angiogenesis indirectly (e.g. transforming growth factor-beta) by stimulating target cells to release angiogenic factors or by other mechanisms. The differential expression, release and activation of these factors might regulate angiogenesis under various physiological and pathological conditions.

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Crossref · 10.1016/0955-2235(90)90010-h

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  • An increase of angiogenic regulators is expected to broadly contribute to improved vascularization and, through increased tissue perfusion, to tissue repair.

    “an increase of angiogenic regulators is expected to broadly contribute to improved vascularization [73, 74] and through this increased perfusion of tissues, to tissue repair.”

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Research works printed but not linked: 50

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Metadata

Authors
Risau, W.
Venue
Progress in Growth Factor Research
Publisher
Elsevier BV
Published
1990-01
Volume
2
Issue
1
Pages
71-79
ISSN
0955-2235
Cited by
145
References
1
Language
en

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