Application of cell culture toxicity tests to the development of implantable biosensors
Abstract
Cell culture toxicity testing methods were modified and applied to the development of implantable glucose microsensors, and positive and negative control materials suitable for the microsensor assessment were established. The location, source and degree of the toxic effect in a multi-component biosensor was spatially visualized with cell monolayers. A freshly prepared sensor showed moderate toxicity, mainly as a result of the presence of glutaraldehyde and the residual solvents in the polymer layers. However, it was possible to reduce the toxicity by removing the leachable toxic substances through extraction in phosphate buffer, and a non-toxic sensor was readily obtained.
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In vitro test outcomes are not an accurate predictor of biocompatibility or glucose sensor performance in vivo.
“their outcomes are not an accurate predictor of biocompatibility or glucose sensor performance in vivo.70,112”
From Biocompatible Materials for Continuous Glucose Monitoring Devices (2013) · cites this paper as [112]
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References 7 · Cited by 25
- Authors
- Zhang, Y., Bindra, D. S., Barrau, M.-B., & Wilson, G. S.
- Affiliations
- University of Kansas (US)
- Corresponding author
- Wilson, George S.
- Venue
- Biosensors and Bioelectronics
- Publisher
- Elsevier BV
- Published
- 1991
- Volume
- 6
- Issue
- 8
- Pages
- 653-661
- ISSN
- 0956-5663 (ISSN-L)
- OpenAlex
- W2090525034
- Cited by
- 25
- References
- 7
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 2 · 2022: 1 · 2020: 1 · 2018: 1 · 2016: 1 · 2015: 1 · 2013: 2 · 2012: 1
- FWCI
- 2.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biosensors and Bioelectronics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01dk030718-12)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK-30718)
- Topics
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Electrochemical sensors and biosensors
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- residual solvents, polymer layers, phosphate buffer extraction, cell monolayers
- MeSH terms
- Agar, Biocompatible Materials, Cell Line, Equipment Design, Glucose, Glutaral, Polymers, Biosensing Techniques
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