DNA damage by drugs and radiation: What is important and how is it measured?

Adriamycin-Induced DNA Damage Mediated by Mammalian DNA Topoisomerase II

Tewey, K. M., Rowe, T. C., Yang, L., Halligan, B. D., & Liu, L. F. (1984) · Science · doi:10.1126/science.6093249 · Cited by 1,542 · see citing works

Supercoiled loops and eucaryotic DNA replication

Vogelstein, B., Pardoll, D. M., & Coffey, D. S. (1980) · Cell · doi:10.1016/0092-8674(80)90156-7 · Cited by 614 · see citing works

The Anticancer Agent Adriamycin Can Be Actively Cytotoxic Without Entering Cells

Triton, T. R., & Yee, G. K. (1982) · Science · doi:10.1126/science.7089561 · Cited by 573 · see citing works

Supercoils in human dna

Cook, P. R., & Brazell, I. A. (1975) · Journal of Cell Science · doi:10.1242/jcs.19.2.261 · Cited by 488 · see citing works

Biochemistry of DNA Lesions

Ward, J. F. (1985) · Radiation Research · doi:10.2307/3576637 · Cited by 441 · see citing works

X-ray-sensitive mutants of Chinese hamster ovary cell line isolation and cross-sensitivity to other DNA-damaging agents

Jeggo, P. A., & Kemp, L. M. (1983) · Mutation Research/DNA Repair Reports · doi:10.1016/0167-8817(83)90026-3 · Cited by 337 · see citing works

The Level of Induced DNA Double-strand Breakage Correlates with Cell Killing after X-irradiation

Radford, I. R. (1985) · International Journal of Radiation Biology and Related Studies in Physics Chemistry and Medicine · doi:10.1080/09553008514551051 · Cited by 310 · see citing works

Mechanism of Action of Antitumor Drug Etoposide: A Review

van Maanen, J. M. S., Retèl, J., de Vries, J., & Pinedo, H. M. (1988) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/80.19.1526 · Cited by 295 · see citing works

Evidence for a General Relationship between the Induced Level of DNA Double-strand Breakage and Cell-killing after X-irradiation of Mammalian Cells

Radford, I. R. (1985) · International Journal of Radiation Biology and Related Studies in Physics Chemistry and Medicine · doi:10.1080/09553008514552861 · Cited by 262 · see citing works

Radiation-Induced Strand Breaks in DNA: Chemical and Enzymatic Analysis of End Groups and Mechanistic Aspects

von Sonntag, C., Hagen, U., Bopp, A., & Schulte‐Frohlinde, D. (1981) · Advances in radiation biology · doi:10.1016/b978-0-12-035409-2.50009-6 · Cited by 223 · see citing works

Differential formation of hydroxyl radicals by adriamycin in sensitive and resistant MCF-7 human breast tumor cells: implications for the mechanism of action

Sinha, B. K., Katki, A. G., Batist, G., et al. (1987) · Biochemistry · doi:10.1021/bi00387a006 · Cited by 214 · see citing works

DNA damage and repair following treatment with ionizing radiation

Powell, S. N., & McMillan, T. J. (1990) · Radiotherapy and Oncology · doi:10.1016/0167-8140(90)90123-e · Cited by 136 · see citing works

Spontaneous DNA Damage and Its Significance for the "Negligible Dose" Controversy in Radiation Protection

Billen, D. (1990) · Radiation Research · doi:10.2307/3577872 · Cited by 120 · see citing works

Unique DNA Repair Properties of a Xeroderma Pigmentosum Revertant

Cleaver, J. E., Cortés, F., Lutze, L. H., Morgan, W. F., Player, A. N., & Mitchell, D. L. (1987) · Molecular and Cellular Biology · doi:10.1128/mcb.7.9.3353 · Cited by 117 · see citing works

Visualization of DNA loops in nucleoids from HeLa cells: Assays for DNA damage and repair

Roti, J. L. R., & Wright, W. D. (1987) · Cytometry · doi:10.1002/cyto.990080505 · Cited by 104 · see citing works

Drug-induced DNA damage and tumor chemosensitivity.

Epstein, R. J. (1990) · Journal of Clinical Oncology · doi:10.1200/jco.1990.8.12.2062 · Cited by 100 · see citing works

Protein kinase C in adriamycin action and resistance in mouse sarcoma 180 cells.

Posada, J. A., Vichi, P., & Tritton, T. R. (1989) · PubMed · Cited by 86 · see citing works

Preferential damage of active chromatin by bleomycin.

Kuo, M. T. (1981) · PubMed · Cited by 85 · see citing works

Mechanisms of DNA repair and their potential modification for radiotherapy

Ward, J. F. (1986) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/0360-3016(86)90220-8 · Cited by 84 · see citing works

The Relationship of DNA Double-strand Break Induction to Radiosensitivity in Human Tumour Cell Lines

McMillan, T. J., Cassoni, A. M., Edwards, S. M., et al. (1990) · International Journal of Radiation Biology · doi:10.1080/09553009014551781 · Cited by 74 · see citing works

Relationship between pyrimidine dimers, 6-4 photoproducts, repair synthesis and cell survival: Studies using cells from patients with trichothiodystrophy

Broughton, B. C., Lehmann, A. R., Harcourt, S. A., Arlett, C. F., Sarasin, A. R., Keijer, W. J., Beemer, F. A., Nairn, R., & Mitchell, D. L. (1990) · Mutation Research/DNA Repair · doi:10.1016/0921-8777(90)90020-6 · Cited by 74 · see citing works

Gamma Radiation as a Probe of Chromatin Structure: Damage to and Repair of Active Chromatin in the Metaphase Chromosome

Oleinick, N. L., Chiu, S., & Friedman, L. R. (1984) · Radiation Research · doi:10.2307/3576494 · Cited by 72 · see citing works

GC-rich regions in genomes as targets for DNA alkylation

Mattes, W. B., Hartley, J. A., Kohn, K. W., & Matheson, D. W. (1988) · Carcinogenesis · doi:10.1093/carcin/9.11.2065 · Cited by 64 · see citing works

Heterogeneity of nitrogen mustard-induced DNA damage and repair at the level of the gene in Chinese hamster ovary cells.

Wassermann, K., Kohn, K. W., & Bohr, V. A. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)77434-6 · Cited by 63 · see citing works

Immunological detection of DNA damage caused by melphalan using monoclonal antibodies.

Tilby, M. J., Styles, J. M., & Dean, C. (1987) · PubMed · Cited by 51 · see citing works

Radiation-Induced Thymine Base Damage in Replicating Chromatin

Warters, R. L., & Childers, T. J. (1982) · Radiation Research · doi:10.2307/3575734 · Cited by 50 · see citing works

Direct Measurement by Pulsed-field Gel Electrophoresis of Induction and Rejoining of X-ray-induced Double-strand Breaks in Cultured Mouse Cells

Ahn, S. Y., Nevaldine, B. H., & Hahn, P. J. (1991) · International Journal of Radiation Biology · doi:10.1080/09553009114550591 · Cited by 46 · see citing works

The Sensitivity of Active and Inactive Chromatin to Ionizing Radiation-induced DNA Strand Breakage

Chiu, S.-M., & Oleinick, N. L. (1982) · International Journal of Radiation Biology and Related Studies in Physics Chemistry and Medicine · doi:10.1080/09553008214550061 · Cited by 45 · see citing works

Molecular assays of radiation-induced DNA damage

Whitaker, S. J., Powell, S. N., & McMillan, T. J. (1991) · European Journal of Cancer and Clinical Oncology · doi:10.1016/0277-5379(91)90148-7 · Cited by 45 · see citing works

In vivo stimulation by antitumor drugs of the topoisomerase II induced cleavage sites in c-myc protooncogene

Riou, J., Multon, É. T., Vilarem, M., Larsen, C., & RIOU, G. F. (1986) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(86)91189-7 · Cited by 43 · see citing works

DNA topoisomerase II cleaves at specific sites in the 5′ flanking region of c‐fos proto‐oncogenes in vitro.

Darby, M. K., Herrera, R. E., Vosberg, H.-P., & Nordheim, A. (1986) · The EMBO Journal · doi:10.1002/j.1460-2075.1986.tb04493.x · Cited by 42 · see citing works

The Level of Induced DNA Double-strand Breaks Does Not Correlate with Cell Killing in X-irradiated Mitotic and G1-phase CHO Cells

Iliakis, G. E., & Okayasu, R. (1988) · International Journal of Radiation Biology · doi:10.1080/09553008814552531 · Cited by 35 · see citing works

Formation of 5-hydroxymethyl-2′-deoxyuridine in hepatic DNA of rats treated with γ-irradiation, diethylnitrosamine, 2-acetylaminofluorene or the peroxisome proliferator ciprofibrate

Srinivasan, S. R., & Glauert, H. P. (1990) · Carcinogenesis · doi:10.1093/carcin/11.11.2021 · Cited by 34 · see citing works

Immunocytochemical analysis of in vivo DNA modification

Engelse, L. D., van Benthem, J., & Scherer, E. (1990) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/0027-5107(90)90169-5 · Cited by 21 · see citing works

Nuclear Lysate Sedimentation Measurements of Peripheral Blood Lymphocytes from Radiotherapy Patients

Deeley, J. O. T., & Moore, J. L. (1989) · International Journal of Radiation Biology · doi:10.1080/09553008914552421 · Cited by 12 · see citing works

Formation and Repair of DNA-Protein Crosslinks in Newly Replicated DNA

Chiu, S., Friedman, L. R., & Oleinick, N. L. (1989) · Radiation Research · doi:10.2307/3577804 · Cited by 9 · see citing works

DNA repair deficiency and senescence in concussed professional athletes involved in contact sports

Schwab, N., Grenier, K., & Hazrati, L.-N. (2019) · Acta Neuropathologica Communications · doi:10.1186/s40478-019-0822-3 · Cited by 47 · see citing works

The role of progesterone-induced blocking factor (PIBF) in invasion of primary ovarian tumour cells

Balassa, T., Berta, G., Bohonyi, N., et al. (2017) · Journal of Reproductive Immunology · doi:10.1016/j.jri.2017.07.027

Cellular Responses to DNA Damage

Klapacz, J., & Gollapudi, B. B. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.95611-3 · Cited by 2 · see citing works

DNA damage repair and cardiovascular diseases

Shukla, P. C., Singh, K. K., Yanagawa, B., Teoh, H., & Verma, S. (2010) · Canadian Journal of Cardiology · doi:10.1016/s0828-282x(10)71055-2 · Cited by 45 · see citing works

Functional interplay between ATM/ATR-mediated DNA damage response and DNA repair pathways in oxidative stress

Yan, S., Sorrell, M., & Berman, Z. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1666-4 · Cited by 247 · see citing works

Interplay between DNA repair and inflammation, and the link to cancer

Kidane, D., Chae, W. J., Czochor, J. R., Eckert, K. A., Glazer, P. M., Bothwell, A. L. M., & Sweasy, J. B. (2014) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2013.875514 · Cited by 186 · see citing works