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Cited by 28Bone Metabolism and DiseasesBone health and osteoporosis researchEstrogen and related hormone effects

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Pathophysiology of bone loss in castrated animals

Schot, L.P.C., Schuurs, A.H.W.M.·1990·The Journal of Steroid Biochemistry and Molecular Biology
DOI 10.1016/0960-0760(90)90499-b
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Abstract

The pathophysiology of bone loss in castrated animals is reviewed. Both male and female rats rapidly lose metaphyseal trabecular bone from the tibia and the femur due to an imbalance between bone resorption and bone formation. The aetiology of sex hormone deficiency-induced bone loss is not fully understood. It seems unlikely that the bone loss is due to changes in the circulating levels of the calciotropic hormones or to an increase in the spontaneous release from peripheral blood monocytes of the bone resorption stimulating cytokine IL-1. Changes in the sensitivity of bone of castrated rats to calciotropic hormones may play a role as well as the lack of direct stimulatory effects of gonadal oestrogens and androgens on bone cells. In addition several data indicate that prostaglandins may be involved.

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Research works printed but not linked: 44

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Metadata

Authors
Schot, L. P. C., & Schuurs, A. H. W. M.
Affiliations
Organon (Netherlands) (NL)
Corresponding author
Schot, L.P.C.
Venue
The Journal of Steroid Biochemistry and Molecular Biology
Publisher
Elsevier BV
Published
1990-11
Volume
37
Issue
3
Pages
461-465
ISSN
0960-0760 (ISSN-L)
DOI
10.1016/0960-0760(90)90499-b
OpenAlex
W1979933759
Cited by
28
References
0
Citations by year
2024: 1 · 2023: 1 · 2022: 1 · 2019: 1 · 2017: 1 · 2015: 3 · 2014: 4
FWCI
0.43
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • The Journal of Steroid Biochemistry and Molecular Biology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Keywords
bone loss, castration, sex hormone deficiency, trabecular bone, bone resorption, bone formation, calciotropic hormones, interleukin-1, prostaglandins, sex steroids, estrogen, androgens, rats
MeSH terms
Animals, Dogs, Female, Humans, Male, Orchiectomy, Osteoporosis, Ovariectomy, Rats

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