Prostaglandins: Stimulation of Bone Resorption in Tissue Culture
Abstract
Prostaglandins (PG’s) stimulated resorption of fetal rat bone in 48–96 hr tissue culture. The effects of several PG’s were compared to the stimulation of bone resorption caused by parathyroid hormone (PTH). PGE1 and PGE2 caused increased release of previously incorporated radioactive calcium into the medium, losses of stable and labeled Ca from the bone and morphologic changes of osteoclastic resorption at 10−5-10−8M. The effects of PGE1 and PGE2 were similar to those of PTH (10−7- 10−8M) but in some experiments the effects of maximal doses of PTH were larger at 48 hr. Like PTH, the effects of PGE1 were inhibited by thyrocalcitonin and cortisol. PGA1 and PGFlα also stimulated bone resorption but only at higher doses (10−5M). In vivo studies demonstrated that injections of PGE1 in parathyroidectomized rats did not increase serum calcium concentration, while parathyroid extract (4–40 U/rat) was effective. (Endocrinology86: 1436, 1970)
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Cytokines such as IL-1 and prostaglandins such as PGE2 can affect bone.
“locally produced cytokines such as IL-1 and prostaglandins such as prostaglandin E 2 (PGE 2 ) can affect bone”
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- Authors
- KLEIN, D. C., & RAISZ, L. G.
- Affiliations
- University of Rochester Medicine (US)
- ORCID
- KLEIN, DAVID C.
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 1970-06
- Volume
- 86
- Issue
- 6
- Pages
- 1436-1440
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W1974402772
- Cited by
- 969
- References
- 0
- Citations by year
- 2026: 3 · 2025: 1 · 2023: 3 · 2022: 5 · 2021: 5 · 2020: 12 · 2019: 5 · 2018: 6 · 2017: 4 · 2016: 7 · 2015: 11 · 2014: 1 · 2013: 8 · 2012: 9
- FWCI
- 5.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Health Sciences › Medicine › Pharmacology › Inflammatory mediators and NSAID effects
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Keywords
- prostaglandins, bone resorption, parathyroid hormone, prostaglandin E1, prostaglandin E2, prostaglandin A1, prostaglandin F1alpha, calcium release, osteoclasts, calcitonin, cortisol, parathyroidectomy, serum calcium
- MeSH terms
- Cyclic AMP, Animals, Bone and Bones, Bone Resorption, Calcitonin, Calcium, Calcium Isotopes, Fetus, Hydrocortisone, Parathyroid Glands, Parathyroid Hormone, Prostaglandin Antagonists, Prostaglandins, Tissue Extracts, Culture Techniques, Rats
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