The DOI matches its Crossref record; 61 of the 63 references it cites were found in a registry or an index.
Steroid hormones as mediators of neural plasticity
Abstract
Steroid and thyroid hormone receptors are expressed in the developing brain and persist throughout adult life. They mediate a variety of effects on the brain, ranging from developmental effects of thyroid hormone and the process of sexual differentiation to the cyclic changes during reproductive cycles in adult female animals. This review summarizes data from the author's laboratory on three topics: (1) actions of extradiol and progesterone on the ventromedial nucleus of the hypothalamus in adult female and male rats, showing both the cyclicity and the consequences of brain sexual differentiation; (2) actions of estradiol on the cholinergic neurons of the basal forebrain of the female and male rat, reflecting the plasticity of the adult cholinergic system as well as sex differences which are developmentally programmed; and (3) diverse actions of estrogens, thyroid hormone and glucocorticoids on the morphology of hippocampal neurons. The review concludes by discussing the interactions between "organizational" (i.e. developmental) effects and the "activational" effects of steroids on the mature nervous system in relation to the environmental control of brain gene expression.
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“Taken in a wider context, these effects of eCD are remarkably similar to those observed in 21 days of chronic restraint stress in rodents, which results in morphologic simplification of prefrontal cortical neurons and impairment in prefrontal mediated behaviors, such as attentional set-shifting or other working memory tasks.35–37”
From Sleep Deprivation and Circadian Disruption (2015) · cites this paper as [37]
Citations
Cites
The Steroid and Thyroid Hormone Receptor Superfamily
Evans, R. M. (1988) · Science · doi:10.1126/science.3283939 · Cited by 7,394
The Neuroendocrinology of Stress and Aging: The Glucocorticoid Cascade Hypothesis
Sapolsky, R. M., Krey, L. C., & McEwen, B. S. (1986) · Science of Aging Knowledge Environment · doi:10.1126/sageke.2002.38.cp21 · Cited by 2,343
Self-citationSTEROID RECEPTOR REGULATED TRANSCRIPTION OF SPECIFIC GENES AND GENE NETWORKS
Yamamoto, K. R. (1985) · Annual Review of Genetics · doi:10.1146/annurev.ge.19.120185.001233 · Cited by 1,850
Gonadal steroids regulate dendritic spine density in hippocampal pyramidal cells in adulthood
Gould, E., Woolley, C., Frankfurt, M., & McEwen, B. (1990) · Journal of Neuroscience · doi:10.1523/jneurosci.10-04-01286.1990 · Cited by 1,406
Self-citationAdrenal steroid receptors and actions in the nervous system
McEwen, B. S., de Kloet, E. R., & Rostène, W. H. (1986) · Physiological Reviews · doi:10.1152/physrev.1986.66.4.1121 · Cited by 1,238
Self-citationWoolley, C. S., Gould, E., & McEwen, B. S. (1990) · Brain Research · doi:10.1016/0006-8993(90)90778-a · Cited by 1,020
Self-citationBasic Neurochemistry: Molecular, Cellular, and Medical Aspects
DAVISON, A. N. (1989) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.52.8.1021-a · Cited by 949
Glucocorticoids Potentiate Ischemic Injury to Neurons: Therapeutic Implications
Sapolsky, R. M., & Pulsinelli, W. A. (1985) · Science · doi:10.1126/science.4035356 · Cited by 678
Frotscher, M., & Léránth, C. (1985) · The Journal of Comparative Neurology · doi:10.1002/cne.902390210 · Cited by 600
Luine, V. N. (1985) · Experimental Neurology · doi:10.1016/0014-4886(85)90108-6 · Cited by 523
Research works printed but not linked: 4
- Romano, 1989, Estrogen increases proenkephalin messenger RNA in the ventromedial hypothalamus of the rat, Molec. Endocr.
- Coirini, 1990, Sex differences in the regulation of oxytocin receptor binding by ovarian steroids in the ventromedial hypothalamic nucleus of the rat, Abstr. Soc. Neurosci., 16, 220
- Frankfurt, 1990, 5,7-Dihydroxytryptamine and castration increase dendritic spine density on ventromedial hypothalamic neurons, Abstr. Soc. Neurosci., 16
- Horner, 1988, Glucocorticoids decrease glucose transport in cultured hippocampal neurons, Soc. Neurosci. Abstr., 14, 372.11
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A Linkage Between DNA Markers on the X Chromosome and Male Sexual Orientation
Hamer, D. H., Hu, S., Magnuson, V. L., Hu, N., & Pattatucci, A. M. L. (1993) · Science · doi:10.1126/science.8332896 · Cited by 873
ProTECT: A Randomized Clinical Trial of Progesterone for Acute Traumatic Brain Injury
Wright, D. W., Kellermann, A. L., Hertzberg, V., Clark, P. L., Frankel, M., Goldstein, F. C., Salomone, J. P., Dent, L. L., Harris, O. A., Ander, D. S., et al. (2006) · Annals of Emergency Medicine · doi:10.1016/j.annemergmed.2006.07.932 · Cited by 599
Psychobiological allostasis: resistance, resilience and vulnerability
Karatsoreos, I. N., & McEwen, B. S. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2011.10.005 · Cited by 458
Self-citationSleep Deprivation and Circadian Disruption
McEwen, B. S., & Karatsoreos, I. N. (2015) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2014.11.007 · Cited by 338
Self-citationCognitive Effects of Endocrine-Disrupting Chemicals in Animals
Schantz, S. L., & Widholm, J. J. (2001) · Environmental Health Perspectives · doi:10.1289/ehp.011091197 · Cited by 250
Metadata
- Authors
- McEwen, B. S., Coirini, H., Westlind-Danielsson, A., Frankfurt, M., Gould, E., Schumacher, M., & Woolley, C.
- Affiliations
- Rockefeller University (US)
- Corresponding author
- McEwen, Bruce S.
- Venue
- The Journal of Steroid Biochemistry and Molecular Biology
- Publisher
- Elsevier BV
- Published
- 1991-08
- Volume
- 39
- Issue
- 2
- Pages
- 223-232
- ISSN
- 0960-0760 (ISSN-L)
- OpenAlex
- W2032190198
- Cited by
- 136
- References
- 63
- Citations by year
- 2024: 1 · 2023: 1 · 2022: 4 · 2021: 4 · 2020: 3 · 2019: 3 · 2018: 2 · 2017: 2 · 2016: 4 · 2015: 3 · 2014: 1 · 2013: 1 · 2012: 4
- FWCI
- 1.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Steroid Biochemistry and Molecular Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (MH-41256)
- National Institute of Neurological Disorders and Stroke (R01NS007080, NS 07080)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- steroid hormones, neuroplasticity, ventromedial hypothalamus, estradiol, progesterone, sexual differentiation of the brain, estrous cycle, cholinergic neurons, basal forebrain, hippocampal neurons, estrogen, thyroid hormones, glucocorticoids, sex differences, organizational effects, activational effects, brain gene expression, reproductive cycle
- MeSH terms
- Animals, Brain, Female, Male, Neuronal Plasticity, Sex Characteristics, Steroids, Rats
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