Effect of putative pheromones on the electrical activity of the human vomeronasal organ and olfactory epithelium
Abstract
The summated receptor potential was recorded from the vomeronasal organ (VNO) and olfactory epithelium (OE) of 49 human subjects of both sexes (18 to 55 years old) using surface non-polarizable silver-silver chloride electrodes. 15-25 pg of human putative pheromones, clove oil and a diluent were administered to the VNO or the OE in 0.3-1 s pulses from a 0.05 mm dia cannula connected to a multichannel delivery system. Local stimulation of the VNO produces negative potentials of 1.8-11.6 mV showing adaptation. Responses are not obtained when the recording electrode is placed in the nasal respiratory mucosa. Pheromone ER-830 significantly stimulates the male VNO (P less than 0.01; n = 20), while ER-670 produces a significant effect on female subjects (P less than 0.001; n = 20). The other pheromones tested do not show significantly different effects in both male and female (P greater than 0.1). Similar quantities of odorant or diluent produce an insignificant effect on the VNO. Stimulation of the OE with clove oil produces depolarization of 12.3 +/- 3.9 mV, while pheromones do not show a significant effect. Our results show that the VNO is a functional organ in adult humans having receptor sites for human putative pheromones.
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The first type of response is a local negative electrical potential, termed the 'electrovomeronasogram' (EVG), recorded from the VNO pit region in awake human subjects.
“The first type of response is a local negative electrical potential, termed the 'electrovomeronasogram' (EVG) (Monti-Bloch and Grosser, 1991), recorded from the VNO pit region in awake human subjects.”
From Human Vomeronasal Organ Function: A Critical Review of Best and Worst Cases (2001) · cites this paper as Monti-Bloch and Grosser, 1991
Monti-Bloch et al. deduce a physiological connection with the brain because stimulus delivery to the VNO pit elicited several systemic responses.
“Although no anatomical connection has been demon-strated, Monti-Bloch et al. deduce a physiological connection with the brain because stimulus delivery to the VNO pit elicited several systemic responses (Monti-Bloch and Grosser, 1991Grosser, , 1998a,b),b).”
From Human Vomeronasal Organ Function: A Critical Review of Best and Worst Cases (2001) · cites this paper as Monti-Bloch and Grosser, 1991
In control experiments the same stimulator was directed at sites successively further from the pit resulting in a decline of EVG amplitude to undetectable levels a short distance away.
“In control experiments the same stimulator was directed at sites successively further from the pit resulting in a decline of EVG amplitude to undetectable levels a short distance away (Monti-Bloch and Grosser, 1991).”
From Human Vomeronasal Organ Function: A Critical Review of Best and Worst Cases (2001) · cites this paper as Monti-Bloch and Grosser, 1991
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References 50 · Cited by 140
- Authors
- Monti-Bloch, L., & Grosser, B. I.
- Affiliations
- University of Utah (US)
- Venue
- The Journal of Steroid Biochemistry and Molecular Biology
- Publisher
- Elsevier BV
- Published
- 1991-10
- Volume
- 39
- Issue
- 4
- Pages
- 573-582
- ISSN
- 0960-0760 (ISSN-L)
- OpenAlex
- W1999788082
- Cited by
- 140
- References
- 50
- Citations by year
- 2023: 5 · 2022: 2 · 2021: 2 · 2020: 4 · 2019: 2 · 2018: 2 · 2017: 5 · 2016: 4 · 2015: 2 · 2014: 2 · 2013: 6
- FWCI
- 2.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Steroid Biochemistry and Molecular Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Physical Sciences › Engineering › Biomedical Engineering › Advanced Chemical Sensor Technologies
- Keywords
- vomeronasal organ, olfactory epithelium, human pheromones, clove oil, receptor potential, sex differences
- MeSH terms
- Adolescent, Adult, Chemoreceptor Cells, Electrophysiology, Female, Humans, Male, Membrane Potentials, Middle Aged, Nasal Septum, Olfactory Mucosa, Olfactory Pathways, Pheromones
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