Coevolution of genetic code and amino acid biosynthesis
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Existing evidence suggests that the genetic code was influenced by physico-chemical interactions between individual amino acids and strings of nucleic acids.
“While existing evidence suggests that the genetic code was influenced by physico-chemical interactions between individual amino acids and strings of nucleic acids [69,86]”
From The Origin of Prebiotic Information System in the Peptide/RNA World: A Simulation Model of the Evolution of Translation and the Genetic Code (2019) · cites this paper as [86]
Cites
On the fundamental nature and evolution of the genetic code
Woese, C. R., Dugre, D. H., Dugre, S. A., Kondo, M., & Saxinger, W. C. (1966) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1966.031.01.093 · Cited by 274 · see citing works
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Origin and evolution of the genetic code: The universal enigma
Koonin, E. V., & Novozhilov, A. S. (2009) · IUBMB Life · doi:10.1002/iub.146 · Cited by 392 · see citing works
Consensus temporal order of amino acids and evolution of the triplet code
Trifonov, E. N. (2000) · Gene · doi:10.1016/s0378-1119(00)00476-5 · Cited by 327 · see citing works
Nonenzymatic Metabolic Reactions and Life’s Origins
Muchowska, K. B., Varma, S. J., & Moran, J. (2020) · Chemical Reviews · doi:10.1021/acs.chemrev.0c00191 · Cited by 317 · see citing works
The Triplet Code From First Principles
Trifonov, E. N. (2004) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2004.10506975 · Cited by 246 · see citing works
RNA–Amino Acid Binding: A Stereochemical Era for the Genetic Code
Yarus, M., Widmann, J. J., & Knight, R. (2009) · Journal of Molecular Evolution · doi:10.1007/s00239-009-9270-1 · Cited by 198 · see citing works
An extension of the coevolution theory of the origin of the genetic code
Di Giulio, M. (2008) · Biology Direct · doi:10.1186/1745-6150-3-37 · Cited by 158 · see citing works
“Conclusion The coevolution theory [9] does not give a complete description of genetic code origin as it seems not to consider that the biosynthetic pathways of the amino acids that first entered the genetic code were important in the earliest phases of the origin of the code itself [9,40,52].”
BackgroundThe origin of the genetic code: Theories and their relationships, a review
Giulio, M. D. (2005) · Biosystems · doi:10.1016/j.biosystems.2004.11.005 · Cited by 157 · see citing works
Coevolution Theory of the Genetic Code at Age Forty: Pathway to Translation and Synthetic Life
Wong, J., Ng, S.-K., Mat, W.-K., Hu, T., & Xue, H. (2016) · Life · doi:10.3390/life6010012 · Cited by 93 · see citing works
Origin of genetically encoded protein synthesis: a model based on selection for RNA peptidation
Wong, J. T.-F. (1991) · Origins of life and evolution of the biosphere · doi:10.1007/bf01809445 · Cited by 86 · see citing works
Chatterjee, S., & Yadav, S. (2019) · Life · doi:10.3390/life9010025 · Cited by 80 · see citing works
“(2) Coevolutionary theory, which suggests that the code structure coevolved with the amino acid biosynthesis pathways [68,86,105].”
BackgroundMethodOn the optimality of the genetic code, with the consideration of termination codons
Goodarzi, H., Nejad, H. A., & Torabi, N. (2004) · Biosystems · doi:10.1016/j.biosystems.2004.05.031 · Cited by 55 · see citing works
Exceptional error minimization in putative primordial genetic codes
Novozhilov, A. S., & Koonin, E. V. (2009) · Biology Direct · doi:10.1186/1745-6150-4-44 · Cited by 37 · see citing works
- Authors
- Tze-Fei Wong, J.
- Venue
- Trends in Biochemical Sciences
- Publisher
- Elsevier BV
- Published
- 1981-01
- Volume
- 6
- Pages
- 33-36
- ISSN
- 0968-0004 (ISSN-L)
- OpenAlex
- W2045384293
- Cited by
- 95
- References
- 1
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 1 · 2023: 2 · 2022: 3 · 2021: 4 · 2020: 2 · 2019: 3 · 2018: 1 · 2017: 3 · 2016: 2 · 2015: 3 · 2014: 4 · 2013: 1
- FWCI
- 0.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Biochemical Sciences (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Physical Sciences › Physics and Astronomy › Astronomy and Astrophysics › Origins and Evolution of Life
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Keywords
- genetic code, amino acid biosynthesis, coevolution, code expansion, amino acid diversity, origin of life
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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