The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
α1-Antitrypsin and the serpins: variation and countervariation
Open accessAbstract
α1-Antitrypsin is a plasma protein which protects elastic tissue from proteolytic attack. Consequently, genetic deficiency, or the oxidation of its reactive centre in cigarette smokers can result in the degenerative lung disease emphysema. Structural studies explain the mechanisms involved and have also drawn attention to a new family of serine proteinase inhibitors. The specificity of each of these inhibitors is primarily dependent on a single amino acid at its reactive centre. Site-directed mutagenesis is enabling the production of specifically designed inhibitors for therapeutic use, including an improved replacement for α1-antitrypsin deficiency.
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Citations
Cites
Protein Inhibitors of Proteinases
Laskowski, M., & Kato, I. (1980) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.49.070180.003113 · Cited by 2,230
HUMAN PLASMA PROTEINASE INHIBITORS
Travis, J., & Salvesen, G. S. (1983) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.52.070183.003255 · Cited by 2,104
Self-citationThe Electrophoretic α; 1 -Globulin Pattern of Serum in α; 1 -Antitrypsin Deficiency
Laurell, C.-B., & Eriksson, S. (1963) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.1080/00365516309051324 · Cited by 1,393
Loebermann, H., Tokuoka, R., Deisenhofer, J., & Huber, R. (1984) · Journal of Molecular Biology · doi:10.1016/0022-2836(84)90298-5 · Cited by 765
Structure and variation of human α1–antitrypsin
Carrell, R. W., Jeppsson, J.-O., Laurell, C.-B., Brennan, S. O., Owen, M. C., Vaughan, L., & Boswell, D. R. (1982) · Nature · doi:10.1038/298329a0 · Cited by 617
Self-citationJohnson, D., & Travis, J. (1979) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)50689-x · Cited by 466
Self-citationOwen, M. C., Brennan, S. O., Lewis, J. H., & Carrell, R. W. (1983) · New England Journal of Medicine · doi:10.1056/nejm198309223091203 · Cited by 426
Self-citationHunt, L. T., & Dayhoff, M. O. (1980) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(80)90867-0 · Cited by 412
The Electrophoretic α;1-Globulin Pattern of Serum in α;1-Antitrypsin Deficiency
Laurell, C. B., & Eriksson, S. (1963) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365516309051324 · Cited by 374
Cochrane, C. G., Spragg, R., & Revak, S. D. (1983) · Journal of Clinical Investigation · doi:10.1172/jci110823 · Cited by 337
Cited by
Crystal structure of uncleaved ovalbumin at 1·95 Å resolution
Stein, P. E., Leslie, A. G. W., Finch, J. T., & Carrell, R. W. (1991) · Journal of Molecular Biology · doi:10.1016/0022-2836(91)80185-w · Cited by 426
Self-citationStructure and properties of ovalbumin
Huntington, J. A., & Stein, P. E. (2001) · Journal of Chromatography B: Biomedical Sciences and Applications · doi:10.1016/s0378-4347(01)00108-6 · Cited by 380
Accelerated evolution in the reactive centre regions of serine protease inhibitors
Hill, R. E., & Hastie, N. D. (1987) · Nature · doi:10.1038/326096a0 · Cited by 288
Metadata
- Authors
- Carrell, R., & Travis, J.
- Venue
- Trends in Biochemical Sciences
- Publisher
- Elsevier BV
- Published
- 1985-01
- Volume
- 10
- Issue
- 1
- Pages
- 20-24
- ISSN
- 0968-0004 (ISSN-L)
- OpenAlex
- W2091437216
- Cited by
- 384
- References
- 15
- FWCI
- 3.58
- Type
- journal article
- Language
- en
- Open access
- green
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- Carrell, R., & Travis, J. (1985). α1-Antitrypsin and the serpins: variation and countervariation. Trends in Biochemical Sciences. https://doi.org/10.1016/0968-0004(85)90011-8
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
