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Cited by 466Protease and Inhibitor MechanismsRedox biology and oxidative stressNeutrophil, Myeloperoxidase and Oxidative Mechanisms

The oxidative inactivation of human alpha-1-proteinase inhibitor. Further evidence for methionine at the reactive center.

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Johnson, D, Travis, J·1979·Journal of Biological Chemistry
DOI 10.1016/s0021-9258(18)50689-x
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  • A1AT potency is entirely abrogated under oxidative conditions due to oxidation of a methionine residue in the P1 position of its protease binding surface.

    “However, the potency of A1AT inhibition is entirely abrogated under oxidative conditions, such as those induced by a neutrophil response to infection, due to the oxidation of a methionine residue in the P1 position (Schechter–Berger nomenclature [13]) of its protease binding surface [14,15].”

    From Discrimination of Methionine Sulfoxide and Sulfone by Human Neutrophil Elastase (2021) · cites this paper as [14]

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Sorted by citations

Authors
Johnson, D., & Travis, J.
Affiliations
University of Georgia (US)
ORCID
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
1979-05
Volume
254
Issue
10
Pages
4022-4026
ISSN
0021-9258 (ISSN-L)
DOI
10.1016/s0021-9258(18)50689-x
OpenAlex
W1583152769
Cited by
466
References
0
Citations by year
2024: 1 · 2023: 1 · 2022: 5 · 2021: 7 · 2020: 6 · 2019: 3 · 2018: 5 · 2017: 5 · 2016: 3 · 2015: 8 · 2014: 4 · 2013: 13 · 2012: 10
FWCI
11.30
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Biological Chemistry (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
  • Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Keywords
alpha 1-proteinase inhibitor, oxidative inactivation, methionine, reactive centers, protein oxidation, protease inhibitors
MeSH terms
alpha 1-Antitrypsin, Amino Acids, Binding Sites, Chymotrypsin, Humans, Kinetics, Methionine, Oxidation-Reduction, Pancreatic Elastase, Trypsin Inhibitors

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