The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Subtilisin — an enzyme designed to be engineered
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Citations
Cites
On the size of the active site in proteases. I. Papain
Schechter, I., & Berger, A. (1967) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(67)80055-x · Cited by 5,204
Serine Proteases: Structure and Mechanism of Catalysis
Kraut, J. (1977) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.46.070177.001555 · Cited by 1,245
Dissecting the catalytic triad of a serine protease
Carter, P., & Wells, J. A. (1988) · Nature · doi:10.1038/332564a0 · Cited by 637
Self-citationCalculation of electrostatic potentials in an enzyme active site
Gilson, M. K., & Honig, B. H. (1987) · Nature · doi:10.1038/330084a0 · Cited by 444
Subtilisin. Stereochemical mechanism involving transition-state stabilization
Robertus, J. D., Kraut, J., Alden, R. A., & Birktoft, J. J. (1972) · Biochemistry · doi:10.1021/bi00773a016 · Cited by 377
Cloning, sequencing, and secretion of Bacillus amyloliquefaciens subtillisin in Bacillus subtilis
Wells, J. A., Ferrari, E., Henner, D. J., Estell, D. A., & Chen, E. Y. (1983) · Nucleic Acids Research · doi:10.1093/nar/11.22.7911 · Cited by 355
Self-citationEngineering an enzyme by site-directed mutagenesis to be resistant to chemical oxidation.
Estell, D. A., Graycar, T. P., & Wells, J. A. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)88811-1 · Cited by 337
Self-citationRational modification of enzyme catalysis by engineering surface charge
Russell, A. J., & Fersht, A. R. (1987) · Nature · doi:10.1038/328496a0 · Cited by 329
Cassette mutagenesis: an efficient method for generation of multiple mutations at defined sites
Wells, J. A., Vasser, M., & Powers, D. B. (1985) · Gene · doi:10.1016/0378-1119(85)90140-4 · Cited by 274
Self-citationProbing Steric and Hydrophobic Effects on Enzyme-Substrate Interactions by Protein Engineering
Estell, D. A., Graycar, T. P., Miller, J. V., Powers, D. B., Wells, J. A., Burnier, J. P., & Ng, P. G. (1986) · Science · doi:10.1126/science.233.4764.659 · Cited by 247
Self-citation
Cited by
Combinatorial and Evolution-Based Methods in the Creation of Enantioselective Catalysts
Reetz, M. T. (2001) · Angewandte Chemie International Edition · doi:10.1002/1521-3773(20010119)40:2<284::aid-anie284>3.0.co;2-n · Cited by 594
Berger, D., & Altmann, T. (2000) · Genes & Development · doi:10.1101/gad.14.9.1119 · Cited by 428
Research Applications of Proteolytic Enzymes in Molecular Biology
Mótyán, J., Tóth, F., & Tőzsér, J. (2013) · Biomolecules · doi:10.3390/biom3040923 · Cited by 267
Minimalist Active‐Site Redesign: Teaching Old Enzymes New Tricks
Toscano, M. D., Woycechowsky, K. J., & Hilvert, D. (2007) · Angewandte Chemie International Edition · doi:10.1002/anie.200604205 · Cited by 262
Gilbert, C., Atlan, D., Blanc, B., Portailer, R., Germond, J. E., Lapierre, L., & Mollet, B. (1996) · Journal of Bacteriology · doi:10.1128/jb.178.11.3059-3065.1996 · Cited by 117
Metadata
- Authors
- Wells, J. A., & Estell, D. A.
- Venue
- Trends in Biochemical Sciences
- Publisher
- Elsevier BV
- Published
- 1988-08
- Volume
- 13
- Issue
- 8
- Pages
- 291-297
- ISSN
- 0968-0004 (ISSN-L)
- OpenAlex
- W1992241700
- Cited by
- 278
- References
- 22
- FWCI
- 2.22
- Type
- journal article
- Language
- en
- Open access
- closed
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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How to cite
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- CoChat. (2026). Citation check: Subtilisin — an enzyme designed to be engineered. https://app.cochat.ai/papers/10.1016/0968-0004(88)90121-1
- The paper
- Wells, J. A., & Estell, D. A. (1988). Subtilisin — an enzyme designed to be engineered. Trends in Biochemical Sciences. https://doi.org/10.1016/0968-0004(88)90121-1
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
