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Serine Proteases: Structure and Mechanism of Catalysis
Abstract
PERSPECTIVES AND SUMMARY .... 331 THE REACTION SEQUENCE AND INTERMEDIATES .... . .. . ..... 333 TRANSITION-STATE STABILIZATION .... .. . . . ... .. . 338 STRUCTURAL FEATURES PARTICIPATING IN CATALYSIS ........ 341 Polypeptide Binding on the Acyl-Group Side 342 Side-Chain Specificity Sites 344 Polypeptide Binding on the Leaving-Group Side 346 Tetrahedral Binding and the Oxyanion Binding Site 348 The Reactive Serine and the Charge Relay System . . . . . . . . . . . . . . . . . . . . . . 351
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Cited by
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Structure of Human Methionine Aminopeptidase-2 Complexed with Fumagillin
Liu, S., Widom, J., Kemp, C. W., Crews, C. M., & Clardy, J. (1998) · Science · doi:10.1126/science.282.5392.1324 · Cited by 440
Mechanism of Heavy Metal Ion Activation of Phytochelatin (PC) Synthase
Vatamaniuk, O. K., Mari, S., Lu, Y.-P., & Rea, P. A. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002997200 · Cited by 390
Herzberg, O., & Moult, J. (1987) · Science · doi:10.1126/science.3107125 · Cited by 351
Jenne, D. E., & Tschopp, J. (1988) · Immunological Reviews · doi:10.1111/j.1600-065x.1988.tb00749.x · Cited by 257
Metadata
- Authors
- Kraut, J.
- Venue
- Annual Review of Biochemistry
- Publisher
- Annual Reviews
- Published
- 1977-06
- Volume
- 46
- Issue
- 1
- Pages
- 331-358
- ISSN
- 0066-4154 (ISSN-L)
- 1545-4509
- OpenAlex
- W2112636022
- Cited by
- 1,245
- References
- 0
- FWCI
- 11.28
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kraut, J. (1977). Serine Proteases: Structure and Mechanism of Catalysis. Annual Review of Biochemistry. https://doi.org/10.1146/annurev.bi.46.070177.001555
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
