Close encounters: why unstructured, polymeric domains can increase rates of specific macromolecular association
Abstract
The rate constants for macromolecular association reactions depend on the macromolecules involved and the solution conditions. The largest rate constants are for encounter-limited reactions, where association takes place whenever the associating macromolecules collide. Macromolecules that associate through specific binding sites often have much smaller rate constants. Recently, it has been demonstrated that the rate of association for complementary nucleic acid strands can be made encounter limited by attaching weakly associating, relatively unstructured polymeric domains to the nucleic acids involved. These results have led to a model suggesting that similar domains provide a general means of increasing rates of association for specific macromolecular binding partners, both in vivo and in vitro.
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Many IDPs/IDRs are capable of at least partial ordering upon interaction with specific partners.
“Many IDPs/IDRs are capable of at least partial ordering upon interaction with specific partners [7–18].”
From Intrinsically disordered proteins play diverse roles in cell signaling (2022) · cites this paper as [16]
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- Authors
- Pontius, B. W.
- Affiliations
- University of Oregon (US)
- Corresponding author
- Pontius, Brian W.
- Venue
- Trends in Biochemical Sciences
- Publisher
- Elsevier BV
- Published
- 1993-05
- Volume
- 18
- Issue
- 5
- Pages
- 181-186
- ISSN
- 0968-0004 (ISSN-L)
- OpenAlex
- W2058353811
- Cited by
- 183
- References
- 31
- Citations by year
- 2025: 4 · 2024: 2 · 2023: 4 · 2022: 4 · 2021: 6 · 2020: 3 · 2019: 3 · 2018: 9 · 2017: 5 · 2016: 3 · 2015: 5 · 2014: 8 · 2013: 7 · 2012: 10
- FWCI
- 0.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Biochemical Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Diffusion and Search Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Advanced biosensing and bioanalysis techniques
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
- Keywords
- macromolecular association, association rate constant, specific binding, nucleic acid hybridization, binding kinetics
- MeSH terms
- Chemistry, Physical, Humans, Kinetics, Polymers, Ribonucleoproteins, Heterogeneous-Nuclear Ribonucleoproteins, Macromolecular Substances, Chemical Phenomena
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